dc.contributor.author | Kar, SP | |
dc.contributor.author | Beesley, J | |
dc.contributor.author | Amin Al Olama, A | |
dc.contributor.author | Michailidou, K | |
dc.contributor.author | Tyrer, J | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Lawrenson, K | |
dc.contributor.author | Lindstrom, S | |
dc.contributor.author | Ramus, SJ | |
dc.contributor.author | Thompson, DJ | |
dc.contributor.author | ABCTB Investigators, | |
dc.contributor.author | Kibel, AS | |
dc.contributor.author | Dansonka-Mieszkowska, A | |
dc.contributor.author | Michael, A | |
dc.contributor.author | Dieffenbach, AK | |
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dc.contributor.author | Wu, AH | |
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dc.contributor.author | Swerdlow, A | |
dc.contributor.author | AOCS Study Group & Australian Cancer Study (Ovarian Cancer), | |
dc.contributor.author | APCB BioResource, | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Ekici, AB | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Phelan, C | |
dc.contributor.author | McLean, C | |
dc.contributor.author | Pearce, CL | |
dc.contributor.author | Vachon, C | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Slavov, C | |
dc.contributor.author | Stegmaier, C | |
dc.contributor.author | Maier, C | |
dc.contributor.author | Ambrosone, CB | |
dc.contributor.author | Høgdall, CK | |
dc.contributor.author | Teerlink, CC | |
dc.contributor.author | Kang, D | |
dc.contributor.author | Tessier, DC | |
dc.contributor.author | Schaid, DJ | |
dc.contributor.author | Stram, DO | |
dc.contributor.author | Cramer, DW | |
dc.contributor.author | Neal, DE | |
dc.contributor.author | Eccles, D | |
dc.contributor.author | Flesch-Janys, D | |
dc.contributor.author | Edwards, DRV | |
dc.contributor.author | Wokozorczyk, D | |
dc.contributor.author | Levine, DA | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Bandera, EV | |
dc.contributor.author | Poole, EM | |
dc.contributor.author | Goode, EL | |
dc.contributor.author | Khusnutdinova, E | |
dc.contributor.author | Høgdall, E | |
dc.contributor.author | Song, F | |
dc.contributor.author | Bruinsma, F | |
dc.contributor.author | Heitz, F | |
dc.contributor.author | Modugno, F | |
dc.contributor.author | Hamdy, FC | |
dc.contributor.author | Wiklund, F | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Olsson, H | |
dc.contributor.author | Wildiers, H | |
dc.contributor.author | Ulmer, H-U | |
dc.contributor.author | Pandha, H | |
dc.contributor.author | Risch, HA | |
dc.contributor.author | Darabi, H | |
dc.contributor.author | Salvesen, HB | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Gronberg, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Song, H | |
dc.contributor.author | Lim, H-Y | |
dc.contributor.author | McNeish, I | |
dc.contributor.author | Campbell, I | |
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dc.contributor.author | Gronwald, J | |
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dc.contributor.author | Stanford, JL | |
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dc.contributor.author | Schildkraut, JM | |
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dc.contributor.author | Cunningham, JM | |
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dc.contributor.author | Batra, J | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Lu, KH | |
dc.contributor.author | Herkommer, K | |
dc.contributor.author | Khaw, K-T | |
dc.contributor.author | kConFab Investigators, | |
dc.contributor.author | Matsuo, K | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Offitt, K | |
dc.contributor.author | Chen, K | |
dc.contributor.author | Moysich, KB | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Odunsi, K | |
dc.contributor.author | Kiemeney, LA | |
dc.contributor.author | Massuger, LFAG | |
dc.contributor.author | Fitzgerald, LM | |
dc.contributor.author | Cook, LS | |
dc.contributor.author | Cannon-Albright, L | |
dc.contributor.author | Hooning, MJ | |
dc.contributor.author | Pike, MC | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Luedeke, M | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Goodman, MT | |
dc.contributor.author | Schmidt, MK | |
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dc.contributor.author | Rossing, MA | |
dc.contributor.author | Beckmann, MW | |
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dc.contributor.author | Lush, M | |
dc.contributor.author | Hildebrandt, MAT | |
dc.contributor.author | Hou, M-F | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Garcia-Closas, M | |
dc.contributor.author | Bogdanova, N | |
dc.contributor.author | Rahman, N | |
dc.contributor.author | NBCS Investigators, | |
dc.contributor.author | Le, ND | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Wentzensen, N | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Peterlongo, P | |
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dc.contributor.author | Kopperud, RK | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Stephenson, RA | |
dc.contributor.author | MacInnis, RJ | |
dc.contributor.author | Hoover, RN | |
dc.contributor.author | Winqvist, R | |
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dc.contributor.author | Olson, SH | |
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dc.contributor.author | Tworoger, SS | |
dc.contributor.author | Maia, S | |
dc.contributor.author | Berndt, S | |
dc.contributor.author | Lee, SC | |
dc.contributor.author | Teo, S-H | |
dc.contributor.author | Thibodeau, SN | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | Kjær, SK | |
dc.contributor.author | Pejovic, T | |
dc.contributor.author | Tammela, TLJ | |
dc.contributor.author | GENICA Network, | |
dc.contributor.author | PRACTICAL consortium, | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Brüning, T | |
dc.contributor.author | Wahlfors, T | |
dc.contributor.author | Key, TJ | |
dc.contributor.author | Edwards, TL | |
dc.contributor.author | Menon, U | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Mitev, V | |
dc.contributor.author | Kosma, V-M | |
dc.contributor.author | Setiawan, VW | |
dc.contributor.author | Kristensen, V | |
dc.contributor.author | Arndt, V | |
dc.contributor.author | Vogel, W | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Sieh, W | |
dc.contributor.author | Blot, WJ | |
dc.contributor.author | Kluzniak, W | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Gao, Y-T | |
dc.contributor.author | Schumacher, F | |
dc.contributor.author | Freedman, ML | |
dc.contributor.author | Berchuck, A | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Spurdle, A | |
dc.contributor.author | Sellers, TA | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Henderson, BE | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Gayther, SA | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Eeles, R | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Lambrechts, D | |
dc.date.accessioned | 2016-10-20T10:38:06Z | |
dc.date.issued | 2016-09-01 | |
dc.identifier.citation | Cancer discovery, 2016, 6 (9), pp. 1052 - 1067 | |
dc.identifier.issn | 2159-8274 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/185 | |
dc.identifier.eissn | 2159-8290 | |
dc.identifier.doi | 10.1158/2159-8290.cd-15-1227 | |
dc.description.abstract | UNLABELLED: Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. Cancer Discov; 6(9); 1052-67. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932. | |
dc.format | Print-Electronic | |
dc.format.extent | 1052 - 1067 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER ASSOC CANCER RESEARCH | |
dc.subject | ABCTB Investigators | |
dc.subject | AOCS Study Group & Australian Cancer Study (Ovarian Cancer) | |
dc.subject | APCB BioResource | |
dc.subject | kConFab Investigators | |
dc.subject | NBCS Investigators | |
dc.subject | GENICA Network | |
dc.subject | PRACTICAL consortium | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Case-Control Studies | |
dc.subject | Chromosome Mapping | |
dc.subject | Signal Transduction | |
dc.subject | Organ Specificity | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Quantitative Trait Loci | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Gene Regulatory Networks | |
dc.subject | Meta-Analysis as Topic | |
dc.subject | Enhancer Elements, Genetic | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Loci | |
dc.subject | Datasets as Topic | |
dc.title | Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-06-07 | |
rioxxterms.versionofrecord | 10.1158/2159-8290.cd-15-1227 | |
rioxxterms.licenseref.startdate | 2016-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cancer discovery | |
pubs.issue | 9 | |
pubs.notes | 12 months | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
pubs.embargo.terms | 12 months | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Genetic Susceptibility | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Garcia-Closas, Montserrat | |
dc.contributor.icrauthor | Eeles, Rosalind | |