dc.contributor.author | Dadaev, T | |
dc.contributor.author | Saunders, EJ | |
dc.contributor.author | Newcombe, PJ | |
dc.contributor.author | Anokian, E | |
dc.contributor.author | Leongamornlert, DA | |
dc.contributor.author | Brook, MN | |
dc.contributor.author | Cieza-Borrella, C | |
dc.contributor.author | Mijuskovic, M | |
dc.contributor.author | Wakerell, S | |
dc.contributor.author | Olama, AAA | |
dc.contributor.author | Schumacher, FR | |
dc.contributor.author | Berndt, SI | |
dc.contributor.author | Benlloch, S | |
dc.contributor.author | Ahmed, M | |
dc.contributor.author | Goh, C | |
dc.contributor.author | Sheng, X | |
dc.contributor.author | Zhang, Z | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Govindasami, K | |
dc.contributor.author | Lophatananon, A | |
dc.contributor.author | Stevens, VL | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | Carter, BD | |
dc.contributor.author | Tangen, CM | |
dc.contributor.author | Goodman, P | |
dc.contributor.author | Thompson, IM | |
dc.contributor.author | Batra, J | |
dc.contributor.author | Chambers, S | |
dc.contributor.author | Moya, L | |
dc.contributor.author | Clements, J | |
dc.contributor.author | Horvath, L | |
dc.contributor.author | Tilley, W | |
dc.contributor.author | Risbridger, G | |
dc.contributor.author | Gronberg, H | |
dc.contributor.author | Aly, M | |
dc.contributor.author | Nordström, T | |
dc.contributor.author | Pharoah, P | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Schleutker, J | |
dc.contributor.author | Tammela, TLJ | |
dc.contributor.author | Sipeky, C | |
dc.contributor.author | Auvinen, A | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Weinstein, S | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Hakansson, N | |
dc.contributor.author | West, C | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Burnet, N | |
dc.contributor.author | Mucci, L | |
dc.contributor.author | Giovannucci, E | |
dc.contributor.author | Andriole, G | |
dc.contributor.author | Cussenot, O | |
dc.contributor.author | Cancel-Tassin, G | |
dc.contributor.author | Koutros, S | |
dc.contributor.author | Freeman, LEB | |
dc.contributor.author | Sorensen, KD | |
dc.contributor.author | Orntoft, TF | |
dc.contributor.author | Borre, M | |
dc.contributor.author | Maehle, L | |
dc.contributor.author | Grindedal, EM | |
dc.contributor.author | Neal, DE | |
dc.contributor.author | Donovan, JL | |
dc.contributor.author | Hamdy, FC | |
dc.contributor.author | Martin, RM | |
dc.contributor.author | Travis, RC | |
dc.contributor.author | Key, TJ | |
dc.contributor.author | Hamilton, RJ | |
dc.contributor.author | Fleshner, NE | |
dc.contributor.author | Finelli, A | |
dc.contributor.author | Ingles, SA | |
dc.contributor.author | Stern, MC | |
dc.contributor.author | Rosenstein, B | |
dc.contributor.author | Kerns, S | |
dc.contributor.author | Ostrer, H | |
dc.contributor.author | Lu, Y-J | |
dc.contributor.author | Zhang, H-W | |
dc.contributor.author | Feng, N | |
dc.contributor.author | Mao, X | |
dc.contributor.author | Guo, X | |
dc.contributor.author | Wang, G | |
dc.contributor.author | Sun, Z | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | MacInnis, RJ | |
dc.contributor.author | FitzGerald, LM | |
dc.contributor.author | Kibel, AS | |
dc.contributor.author | Drake, BF | |
dc.contributor.author | Vega, A | |
dc.contributor.author | Gómez-Caamaño, A | |
dc.contributor.author | Fachal, L | |
dc.contributor.author | Szulkin, R | |
dc.contributor.author | Eklund, M | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Llorca, J | |
dc.contributor.author | Castaño-Vinyals, G | |
dc.contributor.author | Penney, KL | |
dc.contributor.author | Stampfer, M | |
dc.contributor.author | Park, JY | |
dc.contributor.author | Sellers, TA | |
dc.contributor.author | Lin, H-Y | |
dc.contributor.author | Stanford, JL | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Wokolorczyk, D | |
dc.contributor.author | Lubinski, J | |
dc.contributor.author | Ostrander, EA | |
dc.contributor.author | Geybels, MS | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Nielsen, SF | |
dc.contributor.author | Weisher, M | |
dc.contributor.author | Bisbjerg, R | |
dc.contributor.author | Røder, MA | |
dc.contributor.author | Iversen, P | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Cuk, K | |
dc.contributor.author | Holleczek, B | |
dc.contributor.author | Maier, C | |
dc.contributor.author | Luedeke, M | |
dc.contributor.author | Schnoeller, T | |
dc.contributor.author | Kim, J | |
dc.contributor.author | Logothetis, CJ | |
dc.contributor.author | John, EM | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Paulo, P | |
dc.contributor.author | Cardoso, M | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Steele, L | |
dc.contributor.author | Ding, YC | |
dc.contributor.author | De Ruyck, K | |
dc.contributor.author | De Meerleer, G | |
dc.contributor.author | Ost, P | |
dc.contributor.author | Razack, A | |
dc.contributor.author | Lim, J | |
dc.contributor.author | Teo, S-H | |
dc.contributor.author | Lin, DW | |
dc.contributor.author | Newcomb, LF | |
dc.contributor.author | Lessel, D | |
dc.contributor.author | Gamulin, M | |
dc.contributor.author | Kulis, T | |
dc.contributor.author | Kaneva, R | |
dc.contributor.author | Usmani, N | |
dc.contributor.author | Slavov, C | |
dc.contributor.author | Mitev, V | |
dc.contributor.author | Parliament, M | |
dc.contributor.author | Singhal, S | |
dc.contributor.author | Claessens, F | |
dc.contributor.author | Joniau, S | |
dc.contributor.author | Van den Broeck, T | |
dc.contributor.author | Larkin, S | |
dc.contributor.author | Townsend, PA | |
dc.contributor.author | Aukim-Hastie, C | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Castelao, JE | |
dc.contributor.author | Martinez, ME | |
dc.contributor.author | Roobol, MJ | |
dc.contributor.author | Jenster, G | |
dc.contributor.author | van Schaik, RHN | |
dc.contributor.author | Menegaux, F | |
dc.contributor.author | Truong, T | |
dc.contributor.author | Koudou, YA | |
dc.contributor.author | Xu, J | |
dc.contributor.author | Khaw, K-T | |
dc.contributor.author | Cannon-Albright, L | |
dc.contributor.author | Pandha, H | |
dc.contributor.author | Michael, A | |
dc.contributor.author | Kierzek, A | |
dc.contributor.author | Thibodeau, SN | |
dc.contributor.author | McDonnell, SK | |
dc.contributor.author | Schaid, DJ | |
dc.contributor.author | Lindstrom, S | |
dc.contributor.author | Turman, C | |
dc.contributor.author | Ma, J | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Riboli, E | |
dc.contributor.author | Siddiq, A | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Kolonel, LN | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Hoover, RN | |
dc.contributor.author | Machiela, MJ | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, | |
dc.contributor.author | Freedman, M | |
dc.contributor.author | Wiklund, F | |
dc.contributor.author | Chanock, S | |
dc.contributor.author | Henderson, BE | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Conti, DV | |
dc.contributor.author | Kote-Jarai, Z | |
dc.date.accessioned | 2018-06-21T09:56:24Z | |
dc.date.issued | 2018-06-11 | |
dc.identifier.citation | Nature communications, 2018, 9 (1), pp. 2256 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1894 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-018-04109-8 | |
dc.description.abstract | Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. | |
dc.format | Electronic | |
dc.format.extent | 2256 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium | |
dc.subject | Humans | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Multivariate Analysis | |
dc.subject | Bayes Theorem | |
dc.subject | Risk | |
dc.subject | Chromosome Mapping | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Quantitative Trait Loci | |
dc.subject | Algorithms | |
dc.subject | African Continental Ancestry Group | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Male | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Molecular Sequence Annotation | |
dc.title | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-04-05 | |
rioxxterms.versionofrecord | 10.1038/s41467-018-04109-8 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-06-11 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 9 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Saunders, Edward | |
dc.contributor.icrauthor | Brook, Mark | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |