Cross-Stratification and Differential Risk by Breast Cancer Index and Recurrence Score in Women with Hormone Receptor-Positive Lymph Node-Negative Early-Stage Breast Cancer.
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Date
2016-10ICR Author
Author
Sestak, I
Zhang, Y
Schroeder, BE
Schnabel, CA
Dowsett, M
Cuzick, J
Sgroi, D
Type
Journal Article
Metadata
Show full item recordAbstract
Purpose Previous results from the TransATAC study demonstrated that both the Breast Cancer Index (BCI) and the OncotypeDX Recurrence Score (RS) added significant prognostic information to clinicopathologic factors over a 10-year period. Here, we examined cross-stratification between BCI and RS to directly compare their prognostic accuracy at the individual patient level.Experimental design A total of 665 patients with hormone receptor-positive (HR + ) and lymph node-negative disease were included in this retrospective analysis. BCI and RS risk groups were determined using predefined clinical cut-off points. Kaplan-Meier estimates of 10-year risk of distant recurrence (DR) and log-rank tests were used to examine cross-stratification between BCI and RS.Results As previously reported, both RS and BCI were significantly prognostic in years 0 to 10. BCI provided significant additional prognostic information to the Clinical Treatment Score (CTS) plus RS (ΔLR-χ 2 = 11.09; P < 0.001), whereas no additional prognostic information was provided by RS to CTS plus BCI (ΔLR-χ 2 = 2.22; P = 0.1). Restratification by BCI of the low and intermediate RS risk groups led to subgroups with significantly different DR rates (P < 0.001 and P = 0.003, respectively). In contrast, restratified subgroups created by RS of BCI risk groups did not differ significantly.Conclusions In this retrospective analysis, BCI demonstrated increased prognostic accuracy versus RS. Notably, BCI identified subsets of RS low and RS intermediate risk patients with significant and clinically relevant rates of DR. These results indicate that additional subsets of women with HR + , lymph node-negative breast cancer identified by BCI may be suitable candidates for adjuvant chemotherapy or extended endocrine therapy. Clin Cancer Res; 22(20); 5043-8. ©2016 AACRSee related commentary by Brufsky and Davidson, p. 4963.
Collections
Subject
Lymph Nodes
Humans
Breast Neoplasms
Neoplasm Recurrence, Local
Tamoxifen
Nitriles
Triazoles
Receptors, Estrogen
Receptors, Progesterone
Antineoplastic Agents, Hormonal
Prognosis
Health Status Indicators
Risk Factors
Retrospective Studies
Gene Expression Profiling
Female
Anastrozole
Research team
Endocrinology
Language
eng
Date accepted
2016-05-23
License start date
2016-10
Citation
Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, 22 (20), pp. 5043 - 5048