Browsing Breast Cancer Research by author "Meier, Pascal"
Now showing items 1-20 of 30
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An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways.
Kamber Kaya, HE; Ditzel, M; Meier, P; Bergmann, A (PUBLIC LIBRARY SCIENCE, 2017-02-01)Apoptosis is an evolutionary conserved cell death mechanism, which requires activation of initiator and effector caspases. The Drosophila initiator caspase Dronc, the ortholog of mammalian Caspase-2 and Caspase-9, has an ... -
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells.
Wong, P-P; Muñoz-Félix, JM; Hijazi, M; Kim, H; Robinson, SD; et al. (CELL PRESS, 2020-06-11)Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrient delivery. However, this observation has overlooked potential roles for mural cells in directly affecting tumor growth independent ... -
Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.
Horn, S; Hughes, MA; Schilling, R; Sticht, C; Tenev, T; et al. (CELL PRESS, 2017-04-25)Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death signaling by binding to death-receptor-bound FADD. By elucidating the function of the ... -
Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer.
Annibaldi, A; Meier, P (ELSEVIER SCI LTD, 2018-01-01)Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue homeostasis by regulating cytokine production, cell survival, and cell death. However, how life and death decisions are made in response to ... -
Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Martinez Lagunas, K; Savcigil, DP; Zrilic, M; Carvajal Fraile, C; Craxton, A; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2023-07-28)Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is ... -
DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism.
Pernaute, B; Pérez-Montero, S; Sánchez Nieto, JM; Di Gregorio, A; Lima, A; et al. (CELL PRESS, 2022-06-06)The changes that drive differentiation facilitate the emergence of abnormal cells that need to be removed before they contribute to further development or the germline. Consequently, in mice in the lead-up to gastrulation, ... -
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning.
D'Amico, G; Fernandez, I; Gómez-Escudero, J; Kim, H; Maniati, E; et al. (COMPANY BIOLOGISTS LTD, 2022-07-01)Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell ... -
Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.
Salla, M; Aguayo-Ortiz, R; Danmaliki, GI; Zare, A; Said, A; et al. (AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2018-05-01)Receptor-interacting protein kinase 2 (RIP2 or RICK, herein referred to as RIPK2) is linked to the pathogen pathway that activates nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) and autophagic activation. ... -
Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential.
Feltham, R; Jamal, K; Tenev, T; Liccardi, G; Jaco, I; et al. (CELL PRESS, 2018-04-10)Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ... -
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Jaco, I; Annibaldi, A; Lalaoui, N; Wilson, R; Tenev, T; et al. (CELL PRESS, 2017-06-01)TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase ... -
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi, L; Vitale, I; Aaronson, SA; Abrams, JM; Adam, D; et al. (NATURE PUBLISHING GROUP, 2018-03-01)Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the ... -
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
Ciuffa, R; Uliana, F; Mannion, J; Mehnert, M; Tenev, T; et al. (NATL ACAD SCIENCES, 2022-10-04)Protein-protein interactions (PPIs) represent the main mode of the proteome organization in the cell. In the last decade, several large-scale representations of PPI networks have captured generic aspects of the functional ... -
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier, T; Reynolds, LE; Kim, H; Pedrosa, AR; Gómez-Escudero, J; et al. (NATURE PUBLISHING GROUP, 2020-06-04)The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is ... -
PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
Brasó-Maristany, F; Filosto, S; Catchpole, S; Marlow, R; Quist, J; et al. (NATURE PUBLISHING GROUP, 2016-11-01)Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC ... -
Primidone blocks RIPK1-driven cell death and inflammation.
Riebeling, T; Jamal, K; Wilson, R; Kolbrink, B; von Samson-Himmelstjerna, FA; et al. (SPRINGERNATURE, 2020-12-03)The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of ... -
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
Plaza-Menacho, I; Barnouin, K; Barry, R; Borg, A; Orme, M; et al. (CELL PRESS, 2016-12-20)Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable ... -
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.
Liccardi, G; Ramos Garcia, L; Tenev, T; Annibaldi, A; Legrand, AJ; et al. (CELL PRESS, 2019-02-07)Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and ... -
Ripk1 and haematopoiesis: a case for LUBAC and Ripk3.
Annibaldi, A; Meier, P (SPRINGERNATURE, 2018-08-01) -
RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma.
Smith, HG; Jamal, K; Dayal, JH; Tenev, T; Kyula-Currie, J; et al. (WILEY, 2020-06-08)Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti-tumour immunity but not every form of death can elicit an immune ... -
Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis.
Tsapras, P; Petridi, S; Chan, S; Geborys, M; Jacomin, A-C; et al. (CELL PRESS, 2022-01-25)Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical ...