Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer.
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Date
2018-01-01ICR Author
Author
Annibaldi, A
Meier, P
Type
Journal Article
Metadata
Show full item recordAbstract
Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue homeostasis by regulating cytokine production, cell survival, and cell death. However, how life and death decisions are made in response to TNF is poorly understood. Many inflammatory pathologies are now recognized to be driven by aberrant TNF-induced cell death, which, in most circumstances, depends on the kinase Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Recent advances have identified ubiquitin (Ub)-mediated phosphorylation of RIPK1 as belonging to crucial checkpoints for cell fate in inflammation and infection. A better understanding of these checkpoints might lead to new approaches for the treatment of chronic inflammatory diseases fueled by aberrant RIPK1-induced cell death, and/or reveal novel strategies for anticancer immunotherapies, harnessing the ability of RIPK1 to trigger immunogenic cell death.
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Subject
Animals
Humans
Neoplasms
Inflammation
Tumor Necrosis Factor-alpha
NF-kappa B
Ubiquitin
Cell Death
Receptor-Interacting Protein Serine-Threonine Kinases
Research team
Cell Death and Immunity
Language
eng
Date accepted
2017-11-13
License start date
2018-01
Citation
Trends in molecular medicine, 2018, 24 (1), pp. 49 - 65
Publisher
ELSEVIER SCI LTD