Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
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Date
2018-03-01ICR Author
Author
Galluzzi, L
Vitale, I
Aaronson, SA
Abrams, JM
Adam, D
Agostinis, P
Alnemri, ES
Altucci, L
Amelio, I
Andrews, DW
Annicchiarico-Petruzzelli, M
Antonov, AV
Arama, E
Baehrecke, EH
Barlev, NA
Bazan, NG
Bernassola, F
Bertrand, MJM
Bianchi, K
Blagosklonny, MV
Blomgren, K
Borner, C
Boya, P
Brenner, C
Campanella, M
Candi, E
Carmona-Gutierrez, D
Cecconi, F
Chan, FK-M
Chandel, NS
Cheng, EH
Chipuk, JE
Cidlowski, JA
Ciechanover, A
Cohen, GM
Conrad, M
Cubillos-Ruiz, JR
Czabotar, PE
D'Angiolella, V
Dawson, TM
Dawson, VL
De Laurenzi, V
De Maria, R
Debatin, K-M
DeBerardinis, RJ
Deshmukh, M
Di Daniele, N
Di Virgilio, F
Dixit, VM
Dixon, SJ
Duckett, CS
Dynlacht, BD
El-Deiry, WS
Elrod, JW
Fimia, GM
Fulda, S
García-Sáez, AJ
Garg, AD
Garrido, C
Gavathiotis, E
Golstein, P
Gottlieb, E
Green, DR
Greene, LA
Gronemeyer, H
Gross, A
Hajnoczky, G
Hardwick, JM
Harris, IS
Hengartner, MO
Hetz, C
Ichijo, H
Jäättelä, M
Joseph, B
Jost, PJ
Juin, PP
Kaiser, WJ
Karin, M
Kaufmann, T
Kepp, O
Kimchi, A
Kitsis, RN
Klionsky, DJ
Knight, RA
Kumar, S
Lee, SW
Lemasters, JJ
Levine, B
Linkermann, A
Lipton, SA
Lockshin, RA
López-Otín, C
Lowe, SW
Luedde, T
Lugli, E
MacFarlane, M
Madeo, F
Malewicz, M
Malorni, W
Manic, G
Marine, J-C
Martin, SJ
Martinou, J-C
Medema, JP
Mehlen, P
Meier, P
Melino, S
Miao, EA
Molkentin, JD
Moll, UM
Muñoz-Pinedo, C
Nagata, S
Nuñez, G
Oberst, A
Oren, M
Overholtzer, M
Pagano, M
Panaretakis, T
Pasparakis, M
Penninger, JM
Pereira, DM
Pervaiz, S
Peter, ME
Piacentini, M
Pinton, P
Prehn, JHM
Puthalakath, H
Rabinovich, GA
Rehm, M
Rizzuto, R
Rodrigues, CMP
Rubinsztein, DC
Rudel, T
Ryan, KM
Sayan, E
Scorrano, L
Shao, F
Shi, Y
Silke, J
Simon, H-U
Sistigu, A
Stockwell, BR
Strasser, A
Szabadkai, G
Tait, SWG
Tang, D
Tavernarakis, N
Thorburn, A
Tsujimoto, Y
Turk, B
Vanden Berghe, T
Vandenabeele, P
Vander Heiden, MG
Villunger, A
Virgin, HW
Vousden, KH
Vucic, D
Wagner, EF
Walczak, H
Wallach, D
Wang, Y
Wells, JA
Wood, W
Yuan, J
Zakeri, Z
Zhivotovsky, B
Zitvogel, L
Melino, G
Kroemer, G
Type
Journal Article
Metadata
Show full item recordAbstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
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Subject
Lysosomes
Animals
Humans
Necrosis
Mitochondrial Membrane Transport Proteins
Cell Death
Mitochondrial Permeability Transition Pore
Research team
Cell Death and Immunity
Language
eng
Date accepted
2017-10-13
License start date
2018-03
Citation
Cell death and differentiation, 2018, 25 (3), pp. 486 - 541
Publisher
NATURE PUBLISHING GROUP