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dc.date.accessioned2018-07-16T15:28:40Z
dc.date.issued2015-07
dc.identifierhttp://publications.icr.ac.uk/14212/
dc.identifier.citation2015
dc.identifier.issn0962-8436
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2078
dc.description.abstractMulticellularity is characterized by cooperation among cells for the development, maintenance and reproduction of the multicellular organism. Cancer can be viewed as cheating within this cooperative multicellular system. Complex multicellularity, and the cooperation underlying it, has evolved independently multiple times. We review the existing literature on cancer and cancer-like phenomena across life, not only focusing on complex multicellularity but also reviewing cancer-like phenomena across the tree of life more broadly. We find that cancer is characterized by a breakdown of the central features of cooperation that characterize multicellularity, including cheating in proliferation inhibition, cell death, division of labour, resource allocation and extracellular environment maintenance (which we term the five foundations of multicellularity). Cheating on division of labour, exhibited by a lack of differentiation and disorganized cell masses, has been observed in all forms of multicellularity. This suggests that deregulation of differentiation is a fundamental and universal aspect of carcinogenesis that may be underappreciated in cancer biology. Understanding cancer as a breakdown of multicellular cooperation provides novel insights into cancer hallmarks and suggests a set of assays and biomarkers that can be applied across species and characterize the fundamental requirements for generating a cancer.
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectcomplex multicellularity cancer hallmarks major transitions microenvironment division of labour resource allocation NAKED MOLE-RAT PROGRAMMED CELL-DEATH TUMOR-LIKE GROWTHS GALICIA NW SPAIN ASPERGILLUS-NIDULANS SCHIZOPHYLLUM-COMMUNE IN-VITRO DISSEMINATED NEOPLASIA COPRINUS-MACRORHIZUS EXTRACELLULAR-MATRIX Biology
dc.titleCancer across the tree of life: cooperation and cheating in multicellularity
dc.typeJournal Article
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2015-07
rioxxterms.typeJournal Article/Review
pubs.notesISI Document Delivery No.: CK1XN Times Cited: 3 Cited Reference Count: 251 Aktipis, C. Athena Boddy, Amy M. Jansen, Gunther Hibner, Urszula Hochberg, Michael E. Maley, Carlo C. Wilkinson, Gerald S. US National Institutes of Health (NIH) [R01 CA170595, P01 CA91955, R01 CA149566, R01 CA185138, R01 CA140657]; CDMRP Breast Cancer Research Program Award [BC132057]; Sir John Templeton Foundation; Agence National de la Recherche [ANR-13-BSV7-0003-01]; ITMO Cancer [PC201306]; National Science Foundation [DEB-0952260] This publication was made possible through the support of grants by US National Institutes of Health (NIH) R01 CA170595 (to C.C.M., C.A.A., A.M.B.), P01 CA91955 (C.C.M.), R01 CA149566 (C.C.M.), R01 CA185138 (C.C.M., C.A.A.) and R01 CA140657 (C.C.M.), as well as CDMRP Breast Cancer Research Program Award BC132057 (C.C.M., C.A.A.), and the Sir John Templeton Foundation to C.A.A., the Agence National de la Recherche (ANR-13-BSV7-0003-01) to M.E.H., ITMO Cancer (PC201306) to M.E.H. and U.H. and the National Science Foundation (DEB-0952260) to G.S.W. 3 ROYAL SOC LONDON PHILOS T R SOC B
pubs.notesNot known
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pubs.organisational-group/ICR
pubs.embargo.termsNot known
dc.contributor.icrauthorMaley, Carloen
dc.contributor.icrauthorAktipis, Athenaen


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