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dc.date.accessioned2018-07-18T15:06:44Z
dc.date.issued2017-02
dc.identifierhttp://publications.icr.ac.uk/15804/
dc.identifier.citationCold Spring Harbor Perspectives in Medicine, 2017, 17 (2)
dc.identifier.issn2157-1422
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2092
dc.description.abstractEvolution by natural selection is the conceptual foundation for nearly every branch of biology and increasingly also for biomedicine and medical research. In cancer biology, evolution explains how populations of cells in tumors change over time. It is a fundamental question whether this evolutionary process is driven primarily by natural selection and adaptation or by other evolutionary processes such as founder effects and drift. In cancer biology, as in organismal evolutionary biology, there is controversy about this question and also about the use of adaptation through natural selection as a guiding framework for research. In this review, we discuss the differences and similarities between evolution among somatic cells versus evolution among organisms. We review what is known about the parameters and rate of evolution in neoplasms, as well as evidence for adaptation. We conclude that adaptation is a useful framework that accurately explains the defining characteristics of cancer. Further, convergent evolution through natural selection provides the only satisfying explanation both for how a group of diverse pathologies have enough in common to usefully share the descriptive label of "cancer" and for why this convergent condition becomes life-threatening.
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectCOPY NUMBER ALTERATION STEM-CELLS ESOPHAGEAL ADENOCARCINOMA BARRETTS-ESOPHAGUS COLORECTAL-CANCER DRUG-RESISTANCE PROSTATE-CANCER BREAST-CANCER ADAPTATIONIST PROGRAM HORIZONTAL TRANSFER
dc.titleNatural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
dc.typeJournal Article
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCold Spring Harbor Perspectives in Medicine
pubs.issue2
pubs.notesISI Document Delivery No.: EP0CV Times Cited: 0 Cited Reference Count: 104 Fortunato, Angelo Boddy, Amy Mallo, Diego Aktipis, Athena Maley, Carlo C. Pepper, John W. National Institutes of Health (NIH) [P01 CA91955, R01 CA149566, R01 CA170595, R01 CA185138, R01 CA140657]; CDMRP Breast Cancer Research Program Award [BC132057]; National Cancer Institute (NCI) This work is supported in part by National Institutes of Health (NIH) Grants P01 CA91955, R01 CA149566, R01 CA170595, R01 CA185138, and R01 CA140657, as well as CDMRP Breast Cancer Research Program Award BC132057. J.W. P is supported as an employee of the National Cancer Institute (NCI). 0 COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT COLD SPRING HARBOR CSH PERSPECT MED
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume17
pubs.embargo.termsNot known
dc.contributor.icrauthorMaley, Carloen


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