pubs.notes | affiliation: Ji, HP (Reprint Author), Stanford Univ, Dept Med, Sch Med, Div Oncol, Stanford, CA 94305 USA. Andor, Noemi; Xia, Li C.; Ji, Hanlee P., Stanford Univ, Dept Med, Sch Med, Div Oncol, Stanford, CA 94305 USA. Andor, Noemi, German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany. Graham, Trevor A.; Jansen, Marnix, Queen Mary Univ London, Barts Canc Inst, Barts & London Sch Med & Dent, Evolut & Canc Lab, London, England. Aktipis, C. Athena, Univ Calif San Francisco, Ctr Evolut & Canc, San Francisco, CA 94143 USA. Aktipis, C. Athena, Arizona State Univ, Dept Psychol, Tempe, AZ 85287 USA. Petritsch, Claudia, Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA. Petritsch, Claudia, Univ Calif San Francisco, Dept Neurol Surg, Brain Tumor Res Ctr, San Francisco, CA USA. Petritsch, Claudia, Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA. Ji, Hanlee P., Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA. Maley, Carlo C., Inst Canc Res, Ctr Evolut & Canc, London SW3 6JB, England. Maley, Carlo C., Arizona State Univ, Biodesign Inst, Tempe, AZ USA. keywords-plus: LARGE GENE LISTS; CLONAL EVOLUTION; SEQUENCING DATA; WHOLE-GENOME; ESOPHAGEAL ADENOCARCINOMA; LUNG ADENOCARCINOMA; CELL-POPULATIONS; BREAST-CANCER; MUTATIONS; DIVERSITY research-areas: Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine web-of-science-categories: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental author-email: [email protected] [email protected] orcid-numbers: Xia, Charlie/0000-0003-0868-1923 Graham, Trevor/0000-0001-9582-1597 funding-acknowledgement: US National Institutes of Health (NIH) [P01 CA91955, R01 CA149566, R01 CA170595, R01 CA185138, R01 CA140657, P01 HG000205, U01CA151920, U01CA17629901, R01 HG006137, R01 CA164746, R01 NS08061904]; Breast Cancer Research Program Breakthrough Award [BC132057]; Congressionally Directed Medical Research Program (CDMRP); Doris Duke Clinical Foundation Clinical Scientist Development Award; Research Scholar Grant from the American Cancer Society [RSG-13-297-01-TBG]; Howard Hughes Medical Institute Early Career Grant; Don and Ruth Seiler Fund; National Cancer Institute (NCI) Cancer Target Discovery and Development (CTDD) Consortium [U01CA17629901]; Higher Education Founding Council for England (HEFCE) funding-text: This work was supported in part by the US National Institutes of Health (NIH) (grant no. P01 CA91955 (C.C.M.), R01 CA149566 (C.C.M.), R01 CA170595 (C.C.M.), R01 CA185138 (C.C.M.), R01 CA140657 (C.C.M.), P01 HG000205 (H.P.J.), U01CA151920 (H.P.J.), U01CA17629901 (H.P.J.), R01 HG006137 (H.P.J.), R01 CA164746 (C.P.), R01 NS08061904 (C.P.) and R01 HG006137 (L.C.X.)). Additional support to C.C.M. came from the Breast Cancer Research Program Breakthrough Award (award no. BC132057), a Congressionally Directed Medical Research Program (CDMRP). Additional support to H.P.J. came from the Doris Duke Clinical Foundation Clinical Scientist Development Award, a Research Scholar Grant from the American Cancer Society (award no. RSG-13-297-01-TBG) and a Howard Hughes Medical Institute Early Career Grant. N.A. was supported by awards from the Don and Ruth Seiler Fund and the National Cancer Institute (NCI) Cancer Target Discovery and Development (CTDD) Consortium (grant no. U01CA17629901). T.A.G. was supported by the Higher Education Founding Council for England (HEFCE). We are grateful to W. Mewes for advice on the presentation of our results and for insightful discussions about their implications; S.T. Jensen for advice on statistical data analysis; and C.W. Turck and M. Oft for reviewing the manuscript. The results presented here are in part based upon data generated by TCGA Research Network. We thank Hoffmann H. (University of Bonn, Germany) for the availability of the MATLAB function ‘violin’ that we used to generate the violin plots for the distribution of clone numbers and clone sizes. number-of-cited-references: 48 times-cited: 127 usage-count-last-180-days: 10 usage-count-since-2013: 50 journal-iso: Nat. Med. doc-delivery-number: DA1YA unique-id: ISI:000367590700022 oa: green_accepted da: 2018-07-20 | |