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dc.contributor.authorGusev, Aen_US
dc.contributor.authorShi, Hen_US
dc.contributor.authorKichaev, Gen_US
dc.contributor.authorPomerantz, Men_US
dc.contributor.authorLi, Fen_US
dc.contributor.authorLong, HWen_US
dc.contributor.authorIngles, SAen_US
dc.contributor.authorKittles, RAen_US
dc.contributor.authorStrom, SSen_US
dc.contributor.authorRybicki, BAen_US
dc.contributor.authorNemesure, Ben_US
dc.contributor.authorIsaacs, WBen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorPettaway, CAen_US
dc.contributor.authorYeboah, EDen_US
dc.contributor.authorTettey, Yen_US
dc.contributor.authorBiritwum, RBen_US
dc.contributor.authorAdjei, AAen_US
dc.contributor.authorTay, Een_US
dc.contributor.authorTruelove, Aen_US
dc.contributor.authorNiwa, Sen_US
dc.contributor.authorChokkalingam, APen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorMurphy, ABen_US
dc.contributor.authorSignorello, LBen_US
dc.contributor.authorCarpten, Jen_US
dc.contributor.authorLeske, MCen_US
dc.contributor.authorWu, S-Yen_US
dc.contributor.authorHennis, AJMen_US
dc.contributor.authorNeslund-Dudas, Cen_US
dc.contributor.authorHsing, AWen_US
dc.contributor.authorChu, Len_US
dc.contributor.authorGoodman, PJen_US
dc.contributor.authorKlein, EAen_US
dc.contributor.authorWitte, JSen_US
dc.contributor.authorCasey, Gen_US
dc.contributor.authorKaggwa, Sen_US
dc.contributor.authorCook, MBen_US
dc.contributor.authorStram, DOen_US
dc.contributor.authorBlot, WJen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorEaston, Den_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorAl Olama, AAen_US
dc.contributor.authorBenlloch, Sen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorFitzgerald, LMen_US
dc.contributor.authorGronberg, Hen_US
dc.contributor.authorWiklund, Fen_US
dc.contributor.authorAly, Men_US
dc.contributor.authorHenderson, BEen_US
dc.contributor.authorSchleutker, Jen_US
dc.contributor.authorWahlfors, Ten_US
dc.contributor.authorTammela, TLJen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorKey, TJen_US
dc.contributor.authorTravis, RCen_US
dc.contributor.authorNeal, DEen_US
dc.contributor.authorDonovan, JLen_US
dc.contributor.authorHamdy, FCen_US
dc.contributor.authorPharoah, Pen_US
dc.contributor.authorPashayan, Nen_US
dc.contributor.authorKhaw, K-Ten_US
dc.contributor.authorStanford, JLen_US
dc.contributor.authorThibodeau, SNen_US
dc.contributor.authorMcDonnell, SKen_US
dc.contributor.authorSchaid, DJen_US
dc.contributor.authorMaier, Cen_US
dc.contributor.authorVogel, Wen_US
dc.contributor.authorLuedeke, Men_US
dc.contributor.authorHerkommer, Ken_US
dc.contributor.authorKibel, ASen_US
dc.contributor.authorCybulski, Cen_US
dc.contributor.authorWokolorczyk, Den_US
dc.contributor.authorKluzniak, Wen_US
dc.contributor.authorCannon-Albright, Len_US
dc.contributor.authorTeerlink, Cen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorDieffenbach, AKen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorPark, JYen_US
dc.contributor.authorSellers, TAen_US
dc.contributor.authorLin, H-Yen_US
dc.contributor.authorSlavov, Cen_US
dc.contributor.authorKaneva, Ren_US
dc.contributor.authorMitev, Ven_US
dc.contributor.authorBatra, Jen_US
dc.contributor.authorSpurdle, Aen_US
dc.contributor.authorClements, JAen_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorPandha, Hen_US
dc.contributor.authorMichael, Aen_US
dc.contributor.authorPaulo, Pen_US
dc.contributor.authorMaia, Sen_US
dc.contributor.authorKierzek, Aen_US
dc.contributor.authorPRACTICAL consortiumen_US
dc.contributor.authorConti, DVen_US
dc.contributor.authorAlbanes, Den_US
dc.contributor.authorBerg, Cen_US
dc.contributor.authorBerndt, SIen_US
dc.contributor.authorCampa, Den_US
dc.contributor.authorCrawford, EDen_US
dc.contributor.authorDiver, WRen_US
dc.contributor.authorGapstur, SMen_US
dc.contributor.authorGaziano, JMen_US
dc.contributor.authorGiovannucci, Een_US
dc.contributor.authorHoover, Ren_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorJohansson, Men_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLindström, Sen_US
dc.contributor.authorNavarro, Cen_US
dc.contributor.authorOvervad, Ken_US
dc.contributor.authorRiboli, Een_US
dc.contributor.authorSiddiq, Aen_US
dc.contributor.authorStevens, VLen_US
dc.contributor.authorTrichopoulos, Den_US
dc.contributor.authorVineis, Pen_US
dc.contributor.authorYeager, Men_US
dc.contributor.authorTrynka, Gen_US
dc.contributor.authorRaychaudhuri, Sen_US
dc.contributor.authorSchumacher, FRen_US
dc.contributor.authorPrice, ALen_US
dc.contributor.authorFreedman, MLen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorPasaniuc, Ben_US
dc.date.accessioned2016-11-18T16:15:42Z
dc.date.issued2016-04-07en_US
dc.identifier.citationNature communications, 2016, 7 pp. 10979 - ?en_US
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/213
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/ncomms10979en_US
dc.description.abstractAlthough genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.en_US
dc.formatElectronicen_US
dc.format.extent10979 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectPRACTICAL consortiumen_US
dc.subjectCell Line, Tumoren_US
dc.subjectHumansen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectHistonesen_US
dc.subjectEpigenesis, Geneticen_US
dc.subjectAcetylationen_US
dc.subjectInheritance Patternsen_US
dc.subjectLinkage Disequilibriumen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectAfrican Americansen_US
dc.subjectEuropean Continental Ancestry Groupen_US
dc.subjectMaleen_US
dc.subjectAtlases as Topicen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectGenetic Locien_US
dc.titleAtlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-02-03en_US
rioxxterms.versionofrecord10.1038/ncomms10979en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2016-04-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature communicationsen_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.publication-statusPublisheden_US
pubs.volume7en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US
dc.contributor.icrauthorSaunders, Edwarden_US
dc.contributor.icrauthorFisher, Cyrilen_US


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