Show simple item record

dc.contributor.authorSchumacher, FR
dc.contributor.authorAl Olama, AA
dc.contributor.authorBerndt, SI
dc.contributor.authorBenlloch, S
dc.contributor.authorAhmed, M
dc.contributor.authorSaunders, EJ
dc.contributor.authorDadaev, T
dc.contributor.authorLeongamornlert, D
dc.contributor.authorAnokian, E
dc.contributor.authorCieza-Borrella, C
dc.contributor.authorGoh, C
dc.contributor.authorBrook, MN
dc.contributor.authorSheng, X
dc.contributor.authorFachal, L
dc.contributor.authorDennis, J
dc.contributor.authorTyrer, J
dc.contributor.authorMuir, K
dc.contributor.authorLophatananon, A
dc.contributor.authorStevens, VL
dc.contributor.authorGapstur, SM
dc.contributor.authorCarter, BD
dc.contributor.authorTangen, CM
dc.contributor.authorGoodman, PJ
dc.contributor.authorThompson, IM
dc.contributor.authorBatra, J
dc.contributor.authorChambers, S
dc.contributor.authorMoya, L
dc.contributor.authorClements, J
dc.contributor.authorHorvath, L
dc.contributor.authorTilley, W
dc.contributor.authorRisbridger, GP
dc.contributor.authorGronberg, H
dc.contributor.authorAly, M
dc.contributor.authorNordström, T
dc.contributor.authorPharoah, P
dc.contributor.authorPashayan, N
dc.contributor.authorSchleutker, J
dc.contributor.authorTammela, TLJ
dc.contributor.authorSipeky, C
dc.contributor.authorAuvinen, A
dc.contributor.authorAlbanes, D
dc.contributor.authorWeinstein, S
dc.contributor.authorWolk, A
dc.contributor.authorHåkansson, N
dc.contributor.authorWest, CML
dc.contributor.authorDunning, AM
dc.contributor.authorBurnet, N
dc.contributor.authorMucci, LA
dc.contributor.authorGiovannucci, E
dc.contributor.authorAndriole, GL
dc.contributor.authorCussenot, O
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorKoutros, S
dc.contributor.authorBeane Freeman, LE
dc.contributor.authorSorensen, KD
dc.contributor.authorOrntoft, TF
dc.contributor.authorBorre, M
dc.contributor.authorMaehle, L
dc.contributor.authorGrindedal, EM
dc.contributor.authorNeal, DE
dc.contributor.authorDonovan, JL
dc.contributor.authorHamdy, FC
dc.contributor.authorMartin, RM
dc.contributor.authorTravis, RC
dc.contributor.authorKey, TJ
dc.contributor.authorHamilton, RJ
dc.contributor.authorFleshner, NE
dc.contributor.authorFinelli, A
dc.contributor.authorIngles, SA
dc.contributor.authorStern, MC
dc.contributor.authorRosenstein, BS
dc.contributor.authorKerns, SL
dc.contributor.authorOstrer, H
dc.contributor.authorLu, Y-J
dc.contributor.authorZhang, H-W
dc.contributor.authorFeng, N
dc.contributor.authorMao, X
dc.contributor.authorGuo, X
dc.contributor.authorWang, G
dc.contributor.authorSun, Z
dc.contributor.authorGiles, GG
dc.contributor.authorSouthey, MC
dc.contributor.authorMacInnis, RJ
dc.contributor.authorFitzGerald, LM
dc.contributor.authorKibel, AS
dc.contributor.authorDrake, BF
dc.contributor.authorVega, A
dc.contributor.authorGómez-Caamaño, A
dc.contributor.authorSzulkin, R
dc.contributor.authorEklund, M
dc.contributor.authorKogevinas, M
dc.contributor.authorLlorca, J
dc.contributor.authorCastaño-Vinyals, G
dc.contributor.authorPenney, KL
dc.contributor.authorStampfer, M
dc.contributor.authorPark, JY
dc.contributor.authorSellers, TA
dc.contributor.authorLin, H-Y
dc.contributor.authorStanford, JL
dc.contributor.authorCybulski, C
dc.contributor.authorWokolorczyk, D
dc.contributor.authorLubinski, J
dc.contributor.authorOstrander, EA
dc.contributor.authorGeybels, MS
dc.contributor.authorNordestgaard, BG
dc.contributor.authorNielsen, SF
dc.contributor.authorWeischer, M
dc.contributor.authorBisbjerg, R
dc.contributor.authorRøder, MA
dc.contributor.authorIversen, P
dc.contributor.authorBrenner, H
dc.contributor.authorCuk, K
dc.contributor.authorHolleczek, B
dc.contributor.authorMaier, C
dc.contributor.authorLuedeke, M
dc.contributor.authorSchnoeller, T
dc.contributor.authorKim, J
dc.contributor.authorLogothetis, CJ
dc.contributor.authorJohn, EM
dc.contributor.authorTeixeira, MR
dc.contributor.authorPaulo, P
dc.contributor.authorCardoso, M
dc.contributor.authorNeuhausen, SL
dc.contributor.authorSteele, L
dc.contributor.authorDing, YC
dc.contributor.authorDe Ruyck, K
dc.contributor.authorDe Meerleer, G
dc.contributor.authorOst, P
dc.contributor.authorRazack, A
dc.contributor.authorLim, J
dc.contributor.authorTeo, S-H
dc.contributor.authorLin, DW
dc.contributor.authorNewcomb, LF
dc.contributor.authorLessel, D
dc.contributor.authorGamulin, M
dc.contributor.authorKulis, T
dc.contributor.authorKaneva, R
dc.contributor.authorUsmani, N
dc.contributor.authorSinghal, S
dc.contributor.authorSlavov, C
dc.contributor.authorMitev, V
dc.contributor.authorParliament, M
dc.contributor.authorClaessens, F
dc.contributor.authorJoniau, S
dc.contributor.authorVan den Broeck, T
dc.contributor.authorLarkin, S
dc.contributor.authorTownsend, PA
dc.contributor.authorAukim-Hastie, C
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorCastelao, JE
dc.contributor.authorMartinez, ME
dc.contributor.authorRoobol, MJ
dc.contributor.authorJenster, G
dc.contributor.authorvan Schaik, RHN
dc.contributor.authorMenegaux, F
dc.contributor.authorTruong, T
dc.contributor.authorKoudou, YA
dc.contributor.authorXu, J
dc.contributor.authorKhaw, K-T
dc.contributor.authorCannon-Albright, L
dc.contributor.authorPandha, H
dc.contributor.authorMichael, A
dc.contributor.authorThibodeau, SN
dc.contributor.authorMcDonnell, SK
dc.contributor.authorSchaid, DJ
dc.contributor.authorLindstrom, S
dc.contributor.authorTurman, C
dc.contributor.authorMa, J
dc.contributor.authorHunter, DJ
dc.contributor.authorRiboli, E
dc.contributor.authorSiddiq, A
dc.contributor.authorCanzian, F
dc.contributor.authorKolonel, LN
dc.contributor.authorLe Marchand, L
dc.contributor.authorHoover, RN
dc.contributor.authorMachiela, MJ
dc.contributor.authorCui, Z
dc.contributor.authorKraft, P
dc.contributor.authorAmos, CI
dc.contributor.authorConti, DV
dc.contributor.authorEaston, DF
dc.contributor.authorWiklund, F
dc.contributor.authorChanock, SJ
dc.contributor.authorHenderson, BE
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorHaiman, CA
dc.contributor.authorEeles, RA
dc.contributor.authorProfile Study
dc.contributor.authorAustralian Prostate Cancer BioResource (APCB)
dc.contributor.authorIMPACT Study
dc.contributor.authorCanary PASS Investigators
dc.contributor.authorBreast and Prostate Cancer Cohort Consortium (BPC3)
dc.contributor.authorPRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
dc.contributor.authorCancer of the Prostate in Sweden (CAPS)
dc.contributor.authorProstate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS)
dc.contributor.authorGenetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium
dc.date.accessioned2018-07-31T11:42:41Z
dc.date.issued2018-07
dc.identifier.citationNature genetics, 2018, 50 (7), pp. 928 - 936
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2229
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/s41588-018-0142-8
dc.description.abstractGenome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10<sup>-8</sup>) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10<sup>-9</sup>; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10<sup>-9</sup>; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa<sup>1</sup>.
dc.formatPrint-Electronic
dc.format.extent928 - 936
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectProfile Study
dc.subjectAustralian Prostate Cancer BioResource (APCB)
dc.subjectIMPACT Study
dc.subjectCanary PASS Investigators
dc.subjectBreast and Prostate Cancer Cohort Consortium (BPC3)
dc.subjectPRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
dc.subjectCancer of the Prostate in Sweden (CAPS)
dc.subjectProstate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS)
dc.subjectGenetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk
dc.subjectCase-Control Studies
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.titleAssociation analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
dc.typeJournal Article
dcterms.dateAccepted2018-04-05
rioxxterms.versionofrecord10.1038/s41588-018-0142-8
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.publication-statusPublished
pubs.volume50en_US
pubs.embargo.termsNot known
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorSaunders, Edwarden
dc.contributor.icrauthorBrook, Marken


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record