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dc.contributor.authorNatrajan, R
dc.contributor.authorWilkerson, P
dc.date.accessioned2018-07-31T13:36:35Z
dc.date.issued2013-06-05
dc.identifier.citationCancer research, 2013, 73 (12), pp. 3483 - 3488
dc.identifier.issn0008-5472
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2233
dc.identifier.eissn1538-7445
dc.identifier.doi10.1158/0008-5472.can-12-4717
dc.description.abstractCombinatorial approaches that integrate conventional pathology with genomic profiling and functional genomics have begun to enhance our understanding of the genetic basis of breast cancer. These methods have identified key genotypic-phenotypic correlations in different breast cancer subtypes that have led to the discovery of genetic dependencies that drive their behavior. Moreover, this knowledge has been applied to define novel tailored therapies for these groups of patients with cancer. With the current emphasis on characterizing the mutational repertoire of breast cancers by next-generation sequencing, the question remains as to what constitutes a driver event. By focusing efforts on homogenous subgroups of breast cancer and integrating orthogonal data-types combined with functional approaches, we can begin to unravel the heterogeneity and identify aberrations that can be therapeutically targeted.
dc.formatPrint-Electronic
dc.format.extent3483 - 3488
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGene Expression Profiling
dc.subjectGenomics
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectFemale
dc.subjectGenetic Association Studies
dc.subjectMolecular Targeted Therapy
dc.subjectTranslational Medical Research
dc.titleFrom integrative genomics to therapeutic targets.
dc.typeJournal Article
rioxxterms.versionofrecord10.1158/0008-5472.can-12-4717
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2013-06-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer research
pubs.issue12
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics
pubs.publication-statusPublished
pubs.volume73
pubs.embargo.termsNot known
icr.researchteamFunctional Genomicsen_US
dc.contributor.icrauthorNatrajan, Rachaelen


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