From integrative genomics to therapeutic targets.
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Date
2013-06-15ICR Author
Author
Natrajan, R
Wilkerson, P
Type
Journal Article
Metadata
Show full item recordAbstract
Combinatorial approaches that integrate conventional pathology with genomic profiling and functional genomics have begun to enhance our understanding of the genetic basis of breast cancer. These methods have identified key genotypic-phenotypic correlations in different breast cancer subtypes that have led to the discovery of genetic dependencies that drive their behavior. Moreover, this knowledge has been applied to define novel tailored therapies for these groups of patients with cancer. With the current emphasis on characterizing the mutational repertoire of breast cancers by next-generation sequencing, the question remains as to what constitutes a driver event. By focusing efforts on homogenous subgroups of breast cancer and integrating orthogonal data-types combined with functional approaches, we can begin to unravel the heterogeneity and identify aberrations that can be therapeutically targeted.
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Subject
Humans
Breast Neoplasms
Gene Expression Profiling
Genomics
Gene Expression Regulation, Neoplastic
Female
Genetic Association Studies
Molecular Targeted Therapy
Translational Medical Research
Research team
Functional Genomics
Language
eng
License start date
2013-06-05
Citation
Cancer research, 2013, 73 (12), pp. 3483 - 3488
Publisher
AMER ASSOC CANCER RESEARCH