Publications Repository

Publications Repository

View Item 
  •   Home
  • ICR Divisions
  • Breast Cancer Research
  • View Item
  • Home
  • ICR Divisions
  • Breast Cancer Research
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

From integrative genomics to therapeutic targets.

Thumbnail
View/Open
Accepted version (1.040Mb)
Publication Date
2013-06-05
ICR Author
Natrajan, Rachael
Author
Natrajan, R
Wilkerson, P
Type
Journal Article
Metadata
Show full item record
Abstract
Combinatorial approaches that integrate conventional pathology with genomic profiling and functional genomics have begun to enhance our understanding of the genetic basis of breast cancer. These methods have identified key genotypic-phenotypic correlations in different breast cancer subtypes that have led to the discovery of genetic dependencies that drive their behavior. Moreover, this knowledge has been applied to define novel tailored therapies for these groups of patients with cancer. With the current emphasis on characterizing the mutational repertoire of breast cancers by next-generation sequencing, the question remains as to what constitutes a driver event. By focusing efforts on homogenous subgroups of breast cancer and integrating orthogonal data-types combined with functional approaches, we can begin to unravel the heterogeneity and identify aberrations that can be therapeutically targeted.
URL
https://repository.icr.ac.uk/handle/internal/2233
Collections
  • Breast Cancer Research
  • Molecular Pathology
Licenseref URL
http://www.rioxx.net/licenses/all-rights-reserved
Version of record
10.1158/0008-5472.can-12-4717
Subject
Humans
Breast Neoplasms
Gene Expression Profiling
Genomics
Gene Expression Regulation, Neoplastic
Female
Genetic Association Studies
Molecular Targeted Therapy
Translational Medical Research
Research team
Functional Genomics
Language
eng
License start date
2013-06-05
Citation
Cancer research, 2013, 73 (12), pp. 3483 - 3488

Browse

All of ICR repositoryICR DivisionsIssue dateAuthorsTitlesSubjectsThis collectionIssue dateAuthorsTitlesSubjects

Statistics

Most popular itemsStatistics by countryMost popular authors
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.