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Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis

dc.contributor.authorBuckingham, M
dc.contributor.authorRigby, PWJ
dc.date.accessioned2018-08-03T13:08:17Z
dc.date.issued2014-02-10
dc.identifier3
dc.identifier.citationDEVELOPMENTAL CELL, 2014, 28 pp. 225 - 238
dc.identifier.issn1534-5807
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2259
dc.identifier.eissn1878-1551
dc.identifier.doi10.1016/j.devcel.2013.12.020
dc.description.abstractWe discuss the upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model. Key upstream genes, such as Pax3 and Pax7, Six1 and Six4, or Pitx2, participate in gene regulatory networks at different sites of skeletal muscle formation. MicroRNAs also intervene, with emerging evidence for the role of other noncoding RNAs. Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors.
dc.format.extent225 - 238
dc.languageeng
dc.language.isoeng
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/j.devcel.2013.12.020
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2014-02-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfDEVELOPMENTAL CELL
pubs.notesaffiliation: Buckingham, M (Reprint Author), Inst Pasteur, Dept Dev & Stem Cell Biol, CNRS, URA 2578, F-75015 Paris, France. Buckingham, Margaret, Inst Pasteur, Dept Dev & Stem Cell Biol, CNRS, URA 2578, F-75015 Paris, France. Rigby, Peter W. J., Inst Canc Res, Chester Beatty Labs, Div Canc Biol, London SW3 6JB, England. keywords-plus: MUSCLE PROGENITOR CELLS; 6 FAMILY GENES; SKELETAL-MUSCLE; SATELLITE CELLS; MOUSE EMBRYO; PRECURSOR CELLS; BINDING-SITE; SOMITIC MYOGENESIS; MYOD TRANSCRIPTION; SELF-RENEWAL research-areas: Cell Biology; Developmental Biology web-of-science-categories: Cell Biology; Developmental Biology author-email: [email protected] [email protected] funding-acknowledgement: CNRS, Institut Pasteur,; ANR; AFM; EU network Optistem; Institute of Cancer Research funding-text: We are grateful to Alicia Mayeuf for help with making the figures. M.B. acknowledges support from the CNRS, Institut Pasteur, the ANR, the AFM, and the EU network Optistem; P.W.J.R. acknowledges support from the Institute of Cancer Research. We apologize to those whose work we could not discuss, and to those whose work we have not fully cited because of space constraints. number-of-cited-references: 93 times-cited: 147 usage-count-last-180-days: 5 usage-count-since-2013: 58 journal-iso: Dev. Cell doc-delivery-number: AB1ZH unique-id: ISI:000331592300004 oa: gold_or_bronze da: 2018-08-03
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Embryology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Embryology
pubs.volume28
pubs.embargo.termsNot known
icr.researchteamMolecular Embryologyen_US
dc.contributor.icrauthorRigby, Peter William Jack


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