Gene Regulatory Networks and Transcriptional Mechanisms that Control Myogenesis
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Date
2014-02-10ICR Author
Author
Buckingham, M
Rigby, PWJ
Type
Journal Article
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Show full item recordAbstract
We discuss the upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model. Key upstream genes, such as Pax3 and Pax7, Six1 and Six4, or Pitx2, participate in gene regulatory networks at different sites of skeletal muscle formation. MicroRNAs also intervene, with emerging evidence for the role of other noncoding RNAs. Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors.
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Research team
Molecular Embryology
Language
eng
License start date
2014-02-10
Citation
DEVELOPMENTAL CELL, 2014, 28 pp. 225 - 238
Publisher
CELL PRESS