dc.description.abstract | We examined the relationship between body fatness, sports participation and breast cancer risk in 1560 premenopausal cases and 1548 controls, from three related population-based case - control studies in the UK. Half of the women with breast cancer were aged less than 36 years at diagnosis. Women who perceived themselves as plump at age 10 years had a relative risk of 0.83 (95% confidence interval 0.69 - 0.99, P = 0.03) as compared with those who perceived themselves as thin. Self-reported obesity compared with leanness at diagnosis was associated with a relative risk of 0.78 ( 95% confidence interval 0.56 - 1.06, P = 0.11). Women who reported having been plump at age 10 years and overweight or obese at diagnosis had a relative risk of 0.75 ( 95% confidence interval 0.56 - 1.01, P = 0.06) as compared with those who reported being thin at age 10 years and at diagnosis. Findings for three related measures of body fatness suggested that obesity is associated with a reduced risk of premenopausal breast cancer. There was no association between sports participation and breast cancer risk in these premenopausal women. The relative risk for spending an average of more than 1 h per week in sports compared with less from ages 12 to 30 years was 1.00 ( 95% CI 0.86 - 1.16, P = 0.98). | |
pubs.notes | affiliation: Magnusson, CMK (Reprint Author), Karolinska Inst, Dept Publ Hlth Sci, Div Social Med, S-17176 Stockholm, Sweden. Karolinska Inst, Dept Publ Hlth Sci, Div Social Med, S-17176 Stockholm, Sweden. Univ Oxford, Canc Res UK, Epidemiol Unit, Oxford OX3 7LF, England. Univ So Calif, Keck Sch Med, Dept Prevent Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA. Govt Off E Midlands, Dept Hlth, Nottingham NG1 5GG, England. Univ Oxford, John Radcliffe Hosp, Womens Ctr, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England. Inst Canc Res, Canc Res UK, Epidemiol Sect, Sutton SM2 5NG, Surrey, England. Univ London London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1E 7HT, England. Dept Publ Hlth, Unit Hlth Care Epidemiol, Oxford OX3 7LF, England. keywords: childhood; adolescence; body fatness; participation in sports; premenopausal; breast cancer keywords-plus: FLOATING ABSOLUTE RISK; DIFFERENT PERIODS; AMERICAN WOMEN; ADOLESCENCE; CHILDHOOD; POPULATION; ADULTHOOD; EXPOSURES; GROWTH; LIFE research-areas: Oncology web-of-science-categories: Oncology author-email: [email protected] researcherid-numbers: Beral, Valerie/B-2979-2013 orcid-numbers: Magnusson, Cecilia/0000-0002-8567-6725 number-of-cited-references: 23 times-cited: 40 usage-count-last-180-days: 0 usage-count-since-2013: 1 journal-iso: Br. J. Cancer doc-delivery-number: 968FA unique-id: ISI:000232146100015 oa: gold_or_bronze da: 2018-09-04 | |