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dc.contributor.authorBotella, JA
dc.contributor.authorKretzschmar, D
dc.contributor.authorKiermayer, C
dc.contributor.authorFeldmann, P
dc.contributor.authorHughes, DA
dc.contributor.authorSchneuwly, S
dc.date.accessioned2018-09-17T15:09:44Z
dc.date.issued2003-01
dc.identifier1
dc.identifier.citationMOLECULAR BIOLOGY OF THE CELL, 2003, 14 pp. 241 - 250
dc.identifier.issn1059-1524
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2698
dc.identifier.doi10.1091/mbc.E02-05-0297
dc.description.abstractRas signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.
dc.format.extent241 - 250
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.titleDeregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap
dc.typeJournal Article
rioxxterms.versionofrecord10.1091/mbc.E02-05-0297
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2003-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMOLECULAR BIOLOGY OF THE CELL
pubs.notesorcid-numbers: kretzschmar, doris/0000-0002-0519-2377 unique-id: ISI:000180497300020
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume14
pubs.embargo.termsNot known
dc.contributor.icrauthorHughes, David


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