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dc.contributor.authorBotella, JAen_US
dc.contributor.authorKretzschmar, Den_US
dc.contributor.authorKiermayer, Cen_US
dc.contributor.authorFeldmann, Pen_US
dc.contributor.authorHughes, DAen_US
dc.contributor.authorSchneuwly, Sen_US
dc.date.accessioned2018-09-17T15:09:44Z
dc.date.issued2003-01en_US
dc.identifier1en_US
dc.identifier.citationMOLECULAR BIOLOGY OF THE CELL, 2003, 14 pp. 241 - 250en_US
dc.identifier.issn1059-1524en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2698
dc.identifier.doi10.1091/mbc.E02-05-0297en_US
dc.description.abstractRas signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.en_US
dc.format.extent241 - 250en_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.titleDeregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vapen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1091/mbc.E02-05-0297en_US
rioxxterms.licenseref.startdate2003-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfMOLECULAR BIOLOGY OF THE CELLen_US
pubs.notesorcid-numbers: kretzschmar, doris/0000-0002-0519-2377 unique-id: ISI:000180497300020en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume14en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorHughes, Daviden_US


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