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dc.contributor.authorDenholm, Ren_US
dc.contributor.authorDe Stavola, BLen_US
dc.contributor.authorHipwell, JHen_US
dc.contributor.authorDoran, SJen_US
dc.contributor.authorHolly, JMPen_US
dc.contributor.authorFolkerd, Een_US
dc.contributor.authorDowsett, Men_US
dc.contributor.authorLeach, MOen_US
dc.contributor.authorHawkes, DJen_US
dc.contributor.authorDos-Santos-Silva, Ien_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-09-24T09:43:48Z
dc.date.issued2018-12en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30228153en_US
dc.identifier1055-9965.EPI-18-0036en_US
dc.identifier.citationCancer Epidemiol Biomarkers Prev, 2018, 27 (12), pp. 1500 - 1508en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2817
dc.identifier.eissn1538-7755en_US
dc.identifier.doi10.1158/1055-9965.EPI-18-0036en_US
dc.description.abstractBACKGROUND: Endogenous hormones are associated with breast cancer risk, but little is known about their role on breast tissue composition, a strong risk predictor. This study aims to investigate the relationship between growth and sex hormone levels and breast tissue composition in young nulliparous women. METHODS: A cross-sectional study of 415 young (age ∼21.5 years) nulliparous women from an English prebirth cohort underwent a MRI examination of their breasts to estimate percent-water (a proxy for mammographic percent density) and provided a blood sample to measure plasma levels of growth factors (insulin-like growth factor-I, insulin-like growth factor-II, insulin growth factor-binding protein-3, growth hormone) and, if not on hormonal contraception (n = 117) sex hormones (dehydroepiandrosterone, androstenedione, testosterone, estrone, estadiol, sex hormone-binding globulin, prolactin). Testosterone (n = 330) and sex hormone-binding globulin (n = 318) were also measured at age 15.5 years. Regression models were used to estimate the relative difference (RD) in percent-water associated with one SD increment in hormone levels. RESULTS: Estradiol at age 21.5 and sex hormone-binding globulin at age 21.5 were positively associated with body mass index (BMI)-adjusted percent-water [RD (95% confidence interval (CI)): 3% (0%-7%) and 3% (1%-5%), respectively]. There was a positive nonlinear association between androstenedione at age 21.5 and percent-water. Insulin-like growth factor-I and growth hormone at age 21.5 were also positively associated with BMI-adjusted percent-water [RD (95% CI): 2% (0%-4%) and 4% (1%-7%), respectively]. CONCLUSIONS: The findings suggest that endogenous hormones affect breast tissue composition in young nulliparous women. IMPACT: The well-established associations of childhood growth and development with breast cancer risk may be partly mediated by the role of endogenous hormones on breast tissue composition.en_US
dc.format.extent1500 - 1508en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.titleCirculating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-09-07en_US
rioxxterms.versionofrecord10.1158/1055-9965.EPI-18-0036en_US
rioxxterms.licenseref.startdate2018-12en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer Epidemiol Biomarkers Preven_US
pubs.issue12en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublisheden_US
pubs.volume27en_US
pubs.embargo.termsNot knownen_US
icr.researchteamEndocrinologyen_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorDoran, Simonen_US
dc.contributor.icrauthorLeach, Martinen_US
dc.contributor.icrauthorDowsett, Mitchen_US
dc.contributor.icrauthorFolkerd, Elizabethen_US


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