Show simple item record

dc.contributor.authorAmos, CI
dc.contributor.authorDennis, J
dc.contributor.authorWang, Z
dc.contributor.authorByun, J
dc.contributor.authorSchumacher, FR
dc.contributor.authorGayther, SA
dc.contributor.authorCasey, G
dc.contributor.authorHunter, DJ
dc.contributor.authorSellers, TA
dc.contributor.authorGruber, SB
dc.contributor.authorDunning, AM
dc.contributor.authorMichailidou, K
dc.contributor.authorFachal, L
dc.contributor.authorDoheny, K
dc.contributor.authorSpurdle, AB
dc.contributor.authorLi, Y
dc.contributor.authorXiao, X
dc.contributor.authorRomm, J
dc.contributor.authorPugh, E
dc.contributor.authorCoetzee, GA
dc.contributor.authorHazelett, DJ
dc.contributor.authorBojesen, SE
dc.contributor.authorCaga-Anan, C
dc.contributor.authorHaiman, CA
dc.contributor.authorKamal, A
dc.contributor.authorLuccarini, C
dc.contributor.authorTessier, D
dc.contributor.authorVincent, D
dc.contributor.authorBacot, F
dc.contributor.authorVan Den Berg, DJ
dc.contributor.authorNelson, S
dc.contributor.authorDemetriades, S
dc.contributor.authorGoldgar, DE
dc.contributor.authorCouch, FJ
dc.contributor.authorForman, JL
dc.contributor.authorGiles, GG
dc.contributor.authorConti, DV
dc.contributor.authorBickeböller, H
dc.contributor.authorRisch, A
dc.contributor.authorWaldenberger, M
dc.contributor.authorBrüske-Hohlfeld, I
dc.contributor.authorHicks, BD
dc.contributor.authorLing, H
dc.contributor.authorMcGuffog, L
dc.contributor.authorLee, A
dc.contributor.authorKuchenbaecker, K
dc.contributor.authorSoucy, P
dc.contributor.authorManz, J
dc.contributor.authorCunningham, JM
dc.contributor.authorButterbach, K
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorKraft, P
dc.contributor.authorFitzGerald, L
dc.contributor.authorLindström, S
dc.contributor.authorAdams, M
dc.contributor.authorMcKay, JD
dc.contributor.authorPhelan, CM
dc.contributor.authorBenlloch, S
dc.contributor.authorKelemen, LE
dc.contributor.authorBrennan, P
dc.contributor.authorRiggan, M
dc.contributor.authorO'Mara, TA
dc.contributor.authorShen, H
dc.contributor.authorShi, Y
dc.contributor.authorThompson, DJ
dc.contributor.authorGoodman, MT
dc.contributor.authorNielsen, SF
dc.contributor.authorBerchuck, A
dc.contributor.authorLaboissiere, S
dc.contributor.authorSchmit, SL
dc.contributor.authorShelford, T
dc.contributor.authorEdlund, CK
dc.contributor.authorTaylor, JA
dc.contributor.authorField, JK
dc.contributor.authorPark, SK
dc.contributor.authorOffit, K
dc.contributor.authorThomassen, M
dc.contributor.authorSchmutzler, R
dc.contributor.authorOttini, L
dc.contributor.authorHung, RJ
dc.contributor.authorMarchini, J
dc.contributor.authorAmin Al Olama, A
dc.contributor.authorPeters, U
dc.contributor.authorEeles, RA
dc.contributor.authorSeldin, MF
dc.contributor.authorGillanders, E
dc.contributor.authorSeminara, D
dc.contributor.authorAntoniou, AC
dc.contributor.authorPharoah, PDP
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorChanock, SJ
dc.contributor.authorSimard, J
dc.contributor.authorEaston, DF
dc.date.accessioned2018-10-23T14:01:23Z
dc.date.issued2017-01
dc.identifier.citationCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017, 26 (1), pp. 126 - 135
dc.identifier.issn1055-9965
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2905
dc.identifier.eissn1538-7755
dc.identifier.doi10.1158/1055-9965.epi-16-0106
dc.description.abstractBackground Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an inexpensive genotyping microarray, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits.Methods The OncoArray can be genotyped using a novel technology developed by Illumina to facilitate efficient genotyping. The consortium developed standard approaches for selecting SNPs for study, for quality control of markers, and for ancestry analysis. The array was genotyped at selected sites and with prespecified replicate samples to permit evaluation of genotyping accuracy among centers and by ethnic background.Results The OncoArray consortium genotyped 447,705 samples. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis.Conclusions Results from these analyses will enable researchers to identify new susceptibility loci, perform fine-mapping of new or known loci associated with either single or multiple cancers, assess the degree of overlap in cancer causation and pleiotropic effects of loci that have been identified for disease-specific risk, and jointly model genetic, environmental, and lifestyle-related exposures.Impact Ongoing analyses will shed light on etiology and risk assessment for many types of cancer. Cancer Epidemiol Biomarkers Prev; 26(1); 126-35. ©2016 AACR.
dc.formatPrint-Electronic
dc.format.extent126 - 135
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectPrognosis
dc.subjectPrevalence
dc.subjectRisk Assessment
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectFemale
dc.subjectMale
dc.subjectGenetic Variation
dc.subjectGenome-Wide Association Study
dc.subjectSelection, Genetic
dc.titleThe OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.
dc.typeJournal Article
dcterms.dateAccepted2016-07-29
rioxxterms.versionofrecord10.1158/1055-9965.epi-16-0106
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume26
pubs.embargo.termsNot known
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorKote-Jarai, Zsofiaen


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record