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Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

dc.contributor.authorMatejcic, M
dc.contributor.authorSaunders, EJ
dc.contributor.authorDadaev, T
dc.contributor.authorBrook, MN
dc.contributor.authorWang, K
dc.contributor.authorSheng, X
dc.contributor.authorOlama, AAA
dc.contributor.authorSchumacher, FR
dc.contributor.authorIngles, SA
dc.contributor.authorGovindasami, K
dc.contributor.authorBenlloch, S
dc.contributor.authorBerndt, SI
dc.contributor.authorAlbanes, D
dc.contributor.authorKoutros, S
dc.contributor.authorMuir, K
dc.contributor.authorStevens, VL
dc.contributor.authorGapstur, SM
dc.contributor.authorTangen, CM
dc.contributor.authorBatra, J
dc.contributor.authorClements, J
dc.contributor.authorGronberg, H
dc.contributor.authorPashayan, N
dc.contributor.authorSchleutker, J
dc.contributor.authorWolk, A
dc.contributor.authorWest, C
dc.contributor.authorMucci, L
dc.contributor.authorKraft, P
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorSorensen, KD
dc.contributor.authorMaehle, L
dc.contributor.authorGrindedal, EM
dc.contributor.authorStrom, SS
dc.contributor.authorNeal, DE
dc.contributor.authorHamdy, FC
dc.contributor.authorDonovan, JL
dc.contributor.authorTravis, RC
dc.contributor.authorHamilton, RJ
dc.contributor.authorRosenstein, B
dc.contributor.authorLu, Y-J
dc.contributor.authorGiles, GG
dc.contributor.authorKibel, AS
dc.contributor.authorVega, A
dc.contributor.authorBensen, JT
dc.contributor.authorKogevinas, M
dc.contributor.authorPenney, KL
dc.contributor.authorPark, JY
dc.contributor.authorStanford, JL
dc.contributor.authorCybulski, C
dc.contributor.authorNordestgaard, BG
dc.contributor.authorBrenner, H
dc.contributor.authorMaier, C
dc.contributor.authorKim, J
dc.contributor.authorTeixeira, MR
dc.contributor.authorNeuhausen, SL
dc.contributor.authorDe Ruyck, K
dc.contributor.authorRazack, A
dc.contributor.authorNewcomb, LF
dc.contributor.authorLessel, D
dc.contributor.authorKaneva, R
dc.contributor.authorUsmani, N
dc.contributor.authorClaessens, F
dc.contributor.authorTownsend, PA
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorRoobol, MJ
dc.contributor.authorMenegaux, F
dc.contributor.authorKhaw, K-T
dc.contributor.authorCannon-Albright, LA
dc.contributor.authorPandha, H
dc.contributor.authorThibodeau, SN
dc.contributor.authorSchaid, DJ
dc.contributor.authorPRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium,
dc.contributor.authorWiklund, F
dc.contributor.authorChanock, SJ
dc.contributor.authorEaston, DF
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorConti, DV
dc.contributor.authorHaiman, CA
dc.date.accessioned2018-11-26T14:35:48Z
dc.date.issued2018-11-05
dc.identifier.citationNature communications, 2018, 9 (1), pp. 4616 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2952
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-018-06863-1
dc.description.abstractChromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
dc.formatElectronic
dc.format.extent4616 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectPRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
dc.subjectChromosomes, Human, Pair 8
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectDisease Susceptibility
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Markers
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectChromosome Mapping
dc.subjectGenotype
dc.subjectHaplotypes
dc.subjectEuropean Continental Ancestry Group
dc.subjectMale
dc.titleGermline variation at 8q24 and prostate cancer risk in men of European ancestry.
dc.typeJournal Article
dcterms.dateAccepted2018-10-01
rioxxterms.versionofrecord10.1038/s41467-018-06863-1
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-11-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/18/19 Starting Cohort
pubs.publication-statusPublished
pubs.volume9
pubs.embargo.termsNot known
icr.researchteamOncogenetics
dc.contributor.icrauthorSaunders, Edward
dc.contributor.icrauthorBrook, Mark
dc.contributor.icrauthorEeles, Rosalind
dc.contributor.icrauthorKote-Jarai, Zsofia


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