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dc.contributor.authorMatejcic, Men_US
dc.contributor.authorSaunders, EJen_US
dc.contributor.authorDadaev, Ten_US
dc.contributor.authorBrook, MNen_US
dc.contributor.authorWang, Ken_US
dc.contributor.authorSheng, Xen_US
dc.contributor.authorOlama, AAAen_US
dc.contributor.authorSchumacher, FRen_US
dc.contributor.authorIngles, SAen_US
dc.contributor.authorGovindasami, Ken_US
dc.contributor.authorBenlloch, Sen_US
dc.contributor.authorBerndt, SIen_US
dc.contributor.authorAlbanes, Den_US
dc.contributor.authorKoutros, Sen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorStevens, VLen_US
dc.contributor.authorGapstur, SMen_US
dc.contributor.authorTangen, CMen_US
dc.contributor.authorBatra, Jen_US
dc.contributor.authorClements, Jen_US
dc.contributor.authorGronberg, Hen_US
dc.contributor.authorPashayan, Nen_US
dc.contributor.authorSchleutker, Jen_US
dc.contributor.authorWolk, Aen_US
dc.contributor.authorWest, Cen_US
dc.contributor.authorMucci, Len_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorCancel-Tassin, Gen_US
dc.contributor.authorSorensen, KDen_US
dc.contributor.authorMaehle, Len_US
dc.contributor.authorGrindedal, EMen_US
dc.contributor.authorStrom, SSen_US
dc.contributor.authorNeal, DEen_US
dc.contributor.authorHamdy, FCen_US
dc.contributor.authorDonovan, JLen_US
dc.contributor.authorTravis, RCen_US
dc.contributor.authorHamilton, RJen_US
dc.contributor.authorRosenstein, Ben_US
dc.contributor.authorLu, Y-Jen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorKibel, ASen_US
dc.contributor.authorVega, Aen_US
dc.contributor.authorBensen, JTen_US
dc.contributor.authorKogevinas, Men_US
dc.contributor.authorPenney, KLen_US
dc.contributor.authorPark, JYen_US
dc.contributor.authorStanford, JLen_US
dc.contributor.authorCybulski, Cen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorMaier, Cen_US
dc.contributor.authorKim, Jen_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorDe Ruyck, Ken_US
dc.contributor.authorRazack, Aen_US
dc.contributor.authorNewcomb, LFen_US
dc.contributor.authorLessel, Den_US
dc.contributor.authorKaneva, Ren_US
dc.contributor.authorUsmani, Nen_US
dc.contributor.authorClaessens, Fen_US
dc.contributor.authorTownsend, PAen_US
dc.contributor.authorDominguez, MGen_US
dc.contributor.authorRoobol, MJen_US
dc.contributor.authorMenegaux, Fen_US
dc.contributor.authorKhaw, K-Ten_US
dc.contributor.authorCannon-Albright, LAen_US
dc.contributor.authorPandha, Hen_US
dc.contributor.authorThibodeau, SNen_US
dc.contributor.authorSchaid, DJen_US
dc.contributor.authorPRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortiumen_US
dc.contributor.authorWiklund, Fen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorConti, DVen_US
dc.contributor.authorHaiman, CAen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-11-26T14:35:48Z
dc.date.issued2018-11-05en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30397198en_US
dc.identifier10.1038/s41467-018-06863-1en_US
dc.identifier.citationNat Commun, 2018, 9 (1), pp. 4616 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2952
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/s41467-018-06863-1en_US
dc.description.abstractChromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.en_US
dc.format.extent4616 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleGermline variation at 8q24 and prostate cancer risk in men of European ancestry.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-10-01en_US
rioxxterms.versionofrecord10.1038/s41467-018-06863-1en_US
rioxxterms.licenseref.startdate2018-11-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNat Communen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished onlineen_US
pubs.volume9en_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorSaunders, Edwarden_US
dc.contributor.icrauthorBrook, Marken_US
dc.contributor.icrauthorEeles, Rosalinden_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US


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