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dc.contributor.authorAdams, CDen_US
dc.contributor.authorRichmond, Ren_US
dc.contributor.authorFerreira, DLSen_US
dc.contributor.authorSpiller, Wen_US
dc.contributor.authorTan, Ven_US
dc.contributor.authorZheng, Jen_US
dc.contributor.authorWürtz, Pen_US
dc.contributor.authorDonovan, Jen_US
dc.contributor.authorHamdy, Fen_US
dc.contributor.authorNeal, Den_US
dc.contributor.authorLane, JAen_US
dc.contributor.authorSmith, GDen_US
dc.contributor.authorRelton, Cen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorSchumacher, FRen_US
dc.contributor.authorOlama, AAAen_US
dc.contributor.authorBenlloch, Sen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorBerndt, SIen_US
dc.contributor.authorConti, DVen_US
dc.contributor.authorWiklund, Fen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorGapstur, Sen_US
dc.contributor.authorStevens, VLen_US
dc.contributor.authorTangen, CMen_US
dc.contributor.authorBatra, Jen_US
dc.contributor.authorClements, JAen_US
dc.contributor.authorGronberg, Hen_US
dc.contributor.authorPashayan, Nen_US
dc.contributor.authorSchleutker, Jen_US
dc.contributor.authorAlbanes, Den_US
dc.contributor.authorWolk, Aen_US
dc.contributor.authorWest, CMLen_US
dc.contributor.authorMucci, LAen_US
dc.contributor.authorCancel-Tassin, Gen_US
dc.contributor.authorKoutros, Sen_US
dc.contributor.authorSorensen, KDen_US
dc.contributor.authorMaehle, Len_US
dc.contributor.authorTravis, RCen_US
dc.contributor.authorHamilton, RJen_US
dc.contributor.authorIngles, SAen_US
dc.contributor.authorRosenstein, BSen_US
dc.contributor.authorLu, Y-Jen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorKibel, ASen_US
dc.contributor.authorVega, Aen_US
dc.contributor.authorKogevinas, Men_US
dc.contributor.authorPenney, KLen_US
dc.contributor.authorPark, JYen_US
dc.contributor.authorStanford, JLen_US
dc.contributor.authorCybulski, Cen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorMaier, Cen_US
dc.contributor.authorKim, Jen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorDe Ruyck, Ken_US
dc.contributor.authorRazack, Aen_US
dc.contributor.authorNewcomb, LFen_US
dc.contributor.authorLessel, Den_US
dc.contributor.authorKaneva, RPen_US
dc.contributor.authorUsmani, Nen_US
dc.contributor.authorClaessens, Fen_US
dc.contributor.authorTownsend, PAen_US
dc.contributor.authorDominguez, MGen_US
dc.contributor.authorRoobol, MJen_US
dc.contributor.authorMenegaux, Fen_US
dc.contributor.authorKhaw, K-Ten_US
dc.contributor.authorCannon-Albright, LAen_US
dc.contributor.authorPandha, Hen_US
dc.contributor.authorThibodeau, SNen_US
dc.contributor.authorMartin, RMen_US
dc.contributor.authorPRACTICAL consortiumen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2018-11-26T14:40:40Z
dc.date.issued2019-01en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30352818en_US
dc.identifier1055-9965.EPI-18-0079en_US
dc.identifier.citationCancer Epidemiol Biomarkers Prev, 2019, 28 (1), pp. 208 - 216en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2954
dc.identifier.eissn1538-7755en_US
dc.identifier.doi10.1158/1055-9965.EPI-18-0079en_US
dc.description.abstractBACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR). METHODS: The case-control portion of the study was conducted in nine UK centers with men ages 50-69 years who underwent prostate-specific antigen screening for prostate cancer within the Prostate Testing for Cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. RESULTS: Thirty-five metabolites were strongly associated with prostate cancer (P < 0.0014, multiple-testing threshold). These fell into four classes: (i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); (ii) fatty acids and ratios; (iii) amino acids; (iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal. CONCLUSIONS: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk. IMPACT: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification.en_US
dc.format.extent208 - 216en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.titleCirculating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-10-15en_US
rioxxterms.versionofrecord10.1158/1055-9965.EPI-18-0079en_US
rioxxterms.licenseref.startdate2019-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer Epidemiol Biomarkers Preven_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublisheden_US
pubs.volume28en_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US


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