Now showing items 355-369 of 369

    • The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin 

      Krastev, DB; Li, S; Sun, Y; Wicks, AJ; Hoslett, G; Weekes, D; Badder, LM; Knight, EG; Marlow, R; Pardo, MC; Yu, L; Talele, TT; Bartek, J; Choudhary, JS; Pommier, Y; Pettitt, SJ; Tutt, ANJ; Ramadan, K; Lord, CJ
      <jats:title>Abstract</jats:title><jats:p>Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process ...
    • Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance. 

      Garcia, LR; Tenev, T; Newman, R; Haich, RO; Liccardi, G; John, SW; Annibaldi, A; Yu, L; Pardo, M; Young, SN; Fitzgibbon, C; Fernando, W; Guppy, N; Kim, H; Liang, L-Y; Lucet, IS; Kueh, A; Roxanis, I; Gazinska, P; Sims, M; Smyth, T; Ward, G; Bertin, J; Beal, AM; Geddes, B; Choudhary, JS; Murphy, JM; Aurelia Ball, K; Upton, JW; Meier, P (2021-06-07)
      Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which ...
    • Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses. 

      Helassa, N; Dürst, CD; Coates, C; Kerruth, S; Arif, U; Schulze, C; Wiegert, JS; Geeves, M; Oertner, TG; Török, K (2018-05-07)
      Glutamatergic synapses display a rich repertoire of plasticity mechanisms on many different time scales, involving dynamic changes in the efficacy of transmitter release as well as changes in the number and function of ...
    • Ultrahigh Dose-rate Radiotherapy: Next Steps for FLASH-RT. 

      Harrington, KJ (2019-01)
      A new way of delivering radiotherapy at very high dose rates is described and compared with conventional radiotherapy. The ultrahigh dose-rate therapy reduces damage to normal pig skin and exerts potent activity against ...
    • Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53 

      Marais, Richard Malcolm; Pedersen, Malin (2014-07)
      Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear(1,2). The most common somatic mutation in melanoma is a V600E ...
    • Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. 

      Jordan, BK; Mohammed, M; Ching, ST; Délot, E; Chen, XN; Dewing, P; Swain, A; Rao, PN; Elejalde, BR; Vilain, E (2001-05)
      Wnt-4, a member of the Wnt family of locally acting secreted growth factors, is the first signaling molecule shown to influence the sex-determination cascade. In mice, a targeted deletion of Wnt-4 causes the masculinization ...
    • Using Deep Learning to Extrapolate Protein Expression Measurements. 

      Barzine, MP; Freivalds, K; Wright, JC; Opmanis, M; Rituma, D; Ghavidel, FZ; Jarnuczak, AF; Celms, E; Čerāns, K; Jonassen, I; Lace, L; Antonio Vizcaíno, J; Choudhary, JS; Brazma, A; Viksna, J (2020-11)
      Mass spectrometry (MS)-based quantitative proteomics experiments typically assay a subset of up to 60% of the ≈20 000 human protein coding genes. Computational methods for imputing the missing values using RNA expression ...
    • Using inducible degradation to characterise the roles of TRIP13 and CEP57 in mitosis 

      Holt, J (2021-05-31)
      DNA and centrosomes are both semi-conservatively replicated once per cell cycle and it is essential that the DNA and centrosomes are divided equally between daughter cells in mitosis. When this fails, it can lead to ...
    • Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma. 

      Pulido, J; Kottke, T; Thompson, J; Galivo, F; Wongthida, P; Diaz, RM; Rommelfanger, D; Ilett, E; Pease, L; Pandha, H; Harrington, K; Selby, P; Melcher, A; Vile, R (2012-03-18)
      Multiple intravenous injections of a cDNA library, derived from human melanoma cell lines and expressed using the highly immunogenic vector vesicular stomatitis virus (VSV), cured mice with established melanoma tumors. ...
    • Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology. 

      Winfield, JM; Miah, AB; Strauss, D; Thway, K; Collins, DJ; deSouza, NM; Leach, MO; Morgan, VA; Giles, SL; Moskovic, E; Hayes, A; Smith, M; Zaidi, SH; Henderson, D; Messiou, C (2019-01)
      Purpose: To evaluate repeatability of quantitative multi-parametric MRI in retroperitoneal sarcomas, assess parameter changes with radiotherapy, and correlate pre-operative values with histopathological findings in the ...
    • UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. 

      Gozdecka, M; Meduri, E; Mazan, M; Tzelepis, K; Dudek, M; Knights, AJ; Pardo, M; Yu, L; Choudhary, JS; Metzakopian, E; Iyer, V; Yun, H; Park, N; Varela, I; Bautista, R; Collord, G; Dovey, O; Garyfallos, DA; De Braekeleer, E; Kondo, S; Cooper, J; Göttgens, B; Bullinger, L; Northcott, PA; Adams, D; Vassiliou, GS; Huntly, BJP (2018-06)
      The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a ...
    • Visualizing cellular imaging data using PhenoPlot. 

      Sailem, HZ; Sero, JE; Bakal, C (2015-01-08)
      Visualization is essential for data interpretation, hypothesis formulation and communication of results. However, there is a paucity of visualization methods for image-derived data sets generated by high-content analysis ...
    • Warthin Tumor-Like Mucoepidermoid Carcinoma. 

      Heatley, N; Harrington, KJ; Thway, K (2018-02)
      Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. ...
    • WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. 

      Ertay, A; Liu, H; Liu, D; Peng, P; Hill, C; Xiong, H; Hancock, D; Yuan, X; Przewloka, MR; Coldwell, M; Howell, M; Skipp, P; Ewing, RM; Downward, J; Wang, Y (2020-11-21)
      Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer that lacks the oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, making it difficult to target ...
    • WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming. 

      Peñalosa-Ruiz, G; Bousgouni, V; Gerlach, JP; Waarlo, S; van de Ven, JV; Veenstra, TE; Silva, JCR; van Heeringen, SJ; Bakal, C; Mulder, KW; Veenstra, GJC (2019-04)
      Differentiated cells are epigenetically stable, but can be reprogrammed to pluripotency by expression of the OSKM transcription factors. Despite significant effort, relatively little is known about the cellular requirements ...