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dc.contributor.authorTanos, BEen_US
dc.contributor.authorYeaman, Cen_US
dc.contributor.authorRodriguez-Boulan, Een_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2019-02-25T16:11:58Z
dc.date.issued2018-09-03en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/27880081en_US
dc.identifier.citationSmall GTPases, 2018, 9 (5), pp. 375 - 383en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3087
dc.identifier.eissn2154-1256en_US
dc.identifier.doi10.1080/21541248.2016.1244440en_US
dc.description.abstractIQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia.en_US
dc.format.extent375 - 383en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectIQGAP1en_US
dc.subjectcdc42en_US
dc.subjectclaudinsen_US
dc.subjectexocysten_US
dc.subjecttight junctionsen_US
dc.subjectAnimalsen_US
dc.subjectCell Adhesionen_US
dc.subjectHumansen_US
dc.subjectIntercellular Signaling Peptides and Proteinsen_US
dc.subjectNeoplasmsen_US
dc.subjectSignal Transductionen_US
dc.subjectTight Junctionsen_US
dc.subjectras GTPase-Activating Proteinsen_US
dc.titleAn emerging role for IQGAP1 in tight junction control.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1080/21541248.2016.1244440en_US
rioxxterms.licenseref.startdate2018-09-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfSmall GTPasesen_US
pubs.issue5en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.publication-statusPublisheden_US
pubs.volume9en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorTanos, Barbaraen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/