Show simple item record

dc.contributor.authorTanos, BE
dc.contributor.authorYeaman, C
dc.contributor.authorRodriguez-Boulan, E
dc.date.accessioned2019-02-25T16:11:58Z
dc.date.issued2018-09
dc.identifier.citationSmall GTPases, 2018, 9 (5), pp. 375 - 383
dc.identifier.issn2154-1248
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3087
dc.identifier.eissn2154-1256en_US
dc.identifier.doi10.1080/21541248.2016.1244440en_US
dc.description.abstractIQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia.
dc.formatPrint-Electronic
dc.format.extent375 - 383
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTight Junctions
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectras GTPase-Activating Proteins
dc.subjectCell Adhesion
dc.subjectSignal Transduction
dc.titleAn emerging role for IQGAP1 in tight junction control.
dc.typeJournal Article
rioxxterms.versionofrecord10.1080/21541248.2016.1244440
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-09en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfSmall GTPases
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.publication-statusPublished
pubs.volume9en_US
pubs.embargo.termsNot known
dc.contributor.icrauthorTanos, Barbaraen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/