Challenges to curing primary brain tumours.
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Date
2019-08-01Author
Aldape, K
Brindle, KM
Chesler, L
Chopra, R
Gajjar, A
Gilbert, MR
Gottardo, N
Gutmann, DH
Hargrave, D
Holland, EC
Jones, DTW
Joyce, JA
Kearns, P
Kieran, MW
Mellinghoff, IK
Merchant, M
Pfister, SM
Pollard, SM
Ramaswamy, V
Rich, JN
Robinson, GW
Rowitch, DH
Sampson, JH
Taylor, MD
Workman, P
Gilbertson, RJ
Type
Journal Article
Metadata
Show full item recordAbstract
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
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Subject
Humans
Brain Neoplasms
Research team
Paediatric Solid Tumour Biology and Therapeutics
Language
eng
License start date
2019-08
Citation
Nature reviews. Clinical oncology, 2019, 16 (8), pp. 509 - 520
Publisher
NATURE PUBLISHING GROUP