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dc.contributor.authorQian, F
dc.contributor.authorWang, S
dc.contributor.authorMitchell, J
dc.contributor.authorMcGuffog, L
dc.contributor.authorBarrowdale, D
dc.contributor.authorLeslie, G
dc.contributor.authorOosterwijk, JC
dc.contributor.authorChung, WK
dc.contributor.authorEvans, DG
dc.contributor.authorEngel, C
dc.contributor.authorKast, K
dc.contributor.authorAalfs, CM
dc.contributor.authorAdank, MA
dc.contributor.authorAdlard, J
dc.contributor.authorAgnarsson, BA
dc.contributor.authorAittomäki, K
dc.contributor.authorAlducci, E
dc.contributor.authorAndrulis, IL
dc.contributor.authorArun, BK
dc.contributor.authorAusems, MGEM
dc.contributor.authorAzzollini, J
dc.contributor.authorBarouk-Simonet, E
dc.contributor.authorBarwell, J
dc.contributor.authorBelotti, M
dc.contributor.authorBenitez, J
dc.contributor.authorBerger, A
dc.contributor.authorBorg, A
dc.contributor.authorBradbury, AR
dc.contributor.authorBrunet, J
dc.contributor.authorBuys, SS
dc.contributor.authorCaldes, T
dc.contributor.authorCaligo, MA
dc.contributor.authorCampbell, I
dc.contributor.authorCaputo, SM
dc.contributor.authorChiquette, J
dc.contributor.authorClaes, KBM
dc.contributor.authorMargriet Collée, J
dc.contributor.authorCouch, FJ
dc.contributor.authorCoupier, I
dc.contributor.authorDaly, MB
dc.contributor.authorDavidson, R
dc.contributor.authorDiez, O
dc.contributor.authorDomchek, SM
dc.contributor.authorDonaldson, A
dc.contributor.authorDorfling, CM
dc.contributor.authorEeles, R
dc.contributor.authorFeliubadaló, L
dc.contributor.authorForetova, L
dc.contributor.authorFowler, J
dc.contributor.authorFriedman, E
dc.contributor.authorFrost, D
dc.contributor.authorGanz, PA
dc.contributor.authorGarber, J
dc.contributor.authorGarcia-Barberan, V
dc.contributor.authorGlendon, G
dc.contributor.authorGodwin, AK
dc.contributor.authorGómez Garcia, EB
dc.contributor.authorGronwald, J
dc.contributor.authorHahnen, E
dc.contributor.authorHamann, U
dc.contributor.authorHenderson, A
dc.contributor.authorHendricks, CB
dc.contributor.authorHopper, JL
dc.contributor.authorHulick, PJ
dc.contributor.authorImyanitov, EN
dc.contributor.authorIsaacs, C
dc.contributor.authorIzatt, L
dc.contributor.authorIzquierdo, Á
dc.contributor.authorJakubowska, A
dc.contributor.authorKaczmarek, K
dc.contributor.authorKang, E
dc.contributor.authorKarlan, BY
dc.contributor.authorKets, CM
dc.contributor.authorKim, S-W
dc.contributor.authorKim, Z
dc.contributor.authorKwong, A
dc.contributor.authorLaitman, Y
dc.contributor.authorLasset, C
dc.contributor.authorHyuk Lee, M
dc.contributor.authorWon Lee, J
dc.contributor.authorLee, J
dc.contributor.authorLester, J
dc.contributor.authorLesueur, F
dc.contributor.authorLoud, JT
dc.contributor.authorLubinski, J
dc.contributor.authorMebirouk, N
dc.contributor.authorMeijers-Heijboer, HEJ
dc.contributor.authorMeindl, A
dc.contributor.authorMiller, A
dc.contributor.authorMontagna, M
dc.contributor.authorMooij, TM
dc.contributor.authorMorrison, PJ
dc.contributor.authorMouret-Fourme, E
dc.contributor.authorNathanson, KL
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNiederacher, D
dc.contributor.authorNielsen, FC
dc.contributor.authorNussbaum, RL
dc.contributor.authorOffit, K
dc.contributor.authorOlah, E
dc.contributor.authorOng, K-R
dc.contributor.authorOttini, L
dc.contributor.authorPark, SK
dc.contributor.authorPeterlongo, P
dc.contributor.authorPfeiler, G
dc.contributor.authorPhelan, CM
dc.contributor.authorPoppe, B
dc.contributor.authorPradhan, N
dc.contributor.authorRadice, P
dc.contributor.authorRamus, SJ
dc.contributor.authorRantala, J
dc.contributor.authorRobson, M
dc.contributor.authorRodriguez, GC
dc.contributor.authorSchmutzler, RK
dc.contributor.authorHutten Selkirk, CG
dc.contributor.authorShah, PD
dc.contributor.authorSimard, J
dc.contributor.authorSinger, CF
dc.contributor.authorSokolowska, J
dc.contributor.authorStoppa-Lyonnet, D
dc.contributor.authorSutter, C
dc.contributor.authorYen Tan, Y
dc.contributor.authorTeixeira, RM
dc.contributor.authorTeo, SH
dc.contributor.authorTerry, MB
dc.contributor.authorThomassen, M
dc.contributor.authorTischkowitz, M
dc.contributor.authorToland, AE
dc.contributor.authorTucker, KM
dc.contributor.authorTung, N
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorvan Engelen, K
dc.contributor.authorvan Rensburg, EJ
dc.contributor.authorWang-Gohrke, S
dc.contributor.authorWappenschmidt, B
dc.contributor.authorWeitzel, JN
dc.contributor.authorYannoukakos, D
dc.contributor.authorGEMO Study Collaborators,
dc.contributor.authorHEBON,
dc.contributor.authorEMBRACE,
dc.contributor.authorGreene, MH
dc.contributor.authorRookus, MA
dc.contributor.authorEaston, DF
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorAntoniou, AC
dc.contributor.authorGoldgar, DE
dc.contributor.authorOlopade, OI
dc.contributor.authorRebbeck, TR
dc.contributor.authorHuo, D
dc.date.accessioned2019-04-09T14:21:07Z
dc.date.issued2019-04-01
dc.identifier.citationJournal of the National Cancer Institute, 2019, 111 (4), pp. 350 - 364
dc.identifier.issn0027-8874
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3170
dc.identifier.eissn1460-2105
dc.identifier.doi10.1093/jnci/djy132
dc.description.abstractBACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.
dc.formatPrint
dc.format.extent350 - 364
dc.languageeng
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS INC
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectGEMO Study Collaborators
dc.subjectHEBON
dc.subjectEMBRACE
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectBRCA1 Protein
dc.subjectBRCA2 Protein
dc.subjectBody Mass Index
dc.subjectBody Height
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectMutation
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAdult
dc.subjectFemale
dc.subjectMendelian Randomization Analysis
dc.titleHeight and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.
dc.typeJournal Article
dcterms.dateAccepted2018-06-29
rioxxterms.versionofrecord10.1093/jnci/djy132
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2019-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of the National Cancer Institute
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume111
pubs.embargo.termsNot known
icr.researchteamOncogenetics
dc.contributor.icrauthorEeles, Rosalind


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