dc.contributor.author | Qian, F | |
dc.contributor.author | Wang, S | |
dc.contributor.author | Mitchell, J | |
dc.contributor.author | McGuffog, L | |
dc.contributor.author | Barrowdale, D | |
dc.contributor.author | Leslie, G | |
dc.contributor.author | Oosterwijk, JC | |
dc.contributor.author | Chung, WK | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Engel, C | |
dc.contributor.author | Kast, K | |
dc.contributor.author | Aalfs, CM | |
dc.contributor.author | Adank, MA | |
dc.contributor.author | Adlard, J | |
dc.contributor.author | Agnarsson, BA | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Alducci, E | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Arun, BK | |
dc.contributor.author | Ausems, MGEM | |
dc.contributor.author | Azzollini, J | |
dc.contributor.author | Barouk-Simonet, E | |
dc.contributor.author | Barwell, J | |
dc.contributor.author | Belotti, M | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Berger, A | |
dc.contributor.author | Borg, A | |
dc.contributor.author | Bradbury, AR | |
dc.contributor.author | Brunet, J | |
dc.contributor.author | Buys, SS | |
dc.contributor.author | Caldes, T | |
dc.contributor.author | Caligo, MA | |
dc.contributor.author | Campbell, I | |
dc.contributor.author | Caputo, SM | |
dc.contributor.author | Chiquette, J | |
dc.contributor.author | Claes, KBM | |
dc.contributor.author | Margriet Collée, J | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Coupier, I | |
dc.contributor.author | Daly, MB | |
dc.contributor.author | Davidson, R | |
dc.contributor.author | Diez, O | |
dc.contributor.author | Domchek, SM | |
dc.contributor.author | Donaldson, A | |
dc.contributor.author | Dorfling, CM | |
dc.contributor.author | Eeles, R | |
dc.contributor.author | Feliubadaló, L | |
dc.contributor.author | Foretova, L | |
dc.contributor.author | Fowler, J | |
dc.contributor.author | Friedman, E | |
dc.contributor.author | Frost, D | |
dc.contributor.author | Ganz, PA | |
dc.contributor.author | Garber, J | |
dc.contributor.author | Garcia-Barberan, V | |
dc.contributor.author | Glendon, G | |
dc.contributor.author | Godwin, AK | |
dc.contributor.author | Gómez Garcia, EB | |
dc.contributor.author | Gronwald, J | |
dc.contributor.author | Hahnen, E | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Henderson, A | |
dc.contributor.author | Hendricks, CB | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Hulick, PJ | |
dc.contributor.author | Imyanitov, EN | |
dc.contributor.author | Isaacs, C | |
dc.contributor.author | Izatt, L | |
dc.contributor.author | Izquierdo, Á | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Kaczmarek, K | |
dc.contributor.author | Kang, E | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Kets, CM | |
dc.contributor.author | Kim, S-W | |
dc.contributor.author | Kim, Z | |
dc.contributor.author | Kwong, A | |
dc.contributor.author | Laitman, Y | |
dc.contributor.author | Lasset, C | |
dc.contributor.author | Hyuk Lee, M | |
dc.contributor.author | Won Lee, J | |
dc.contributor.author | Lee, J | |
dc.contributor.author | Lester, J | |
dc.contributor.author | Lesueur, F | |
dc.contributor.author | Loud, JT | |
dc.contributor.author | Lubinski, J | |
dc.contributor.author | Mebirouk, N | |
dc.contributor.author | Meijers-Heijboer, HEJ | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Miller, A | |
dc.contributor.author | Montagna, M | |
dc.contributor.author | Mooij, TM | |
dc.contributor.author | Morrison, PJ | |
dc.contributor.author | Mouret-Fourme, E | |
dc.contributor.author | Nathanson, KL | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Niederacher, D | |
dc.contributor.author | Nielsen, FC | |
dc.contributor.author | Nussbaum, RL | |
dc.contributor.author | Offit, K | |
dc.contributor.author | Olah, E | |
dc.contributor.author | Ong, K-R | |
dc.contributor.author | Ottini, L | |
dc.contributor.author | Park, SK | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Pfeiler, G | |
dc.contributor.author | Phelan, CM | |
dc.contributor.author | Poppe, B | |
dc.contributor.author | Pradhan, N | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Ramus, SJ | |
dc.contributor.author | Rantala, J | |
dc.contributor.author | Robson, M | |
dc.contributor.author | Rodriguez, GC | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Hutten Selkirk, CG | |
dc.contributor.author | Shah, PD | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Singer, CF | |
dc.contributor.author | Sokolowska, J | |
dc.contributor.author | Stoppa-Lyonnet, D | |
dc.contributor.author | Sutter, C | |
dc.contributor.author | Yen Tan, Y | |
dc.contributor.author | Teixeira, RM | |
dc.contributor.author | Teo, SH | |
dc.contributor.author | Terry, MB | |
dc.contributor.author | Thomassen, M | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Tucker, KM | |
dc.contributor.author | Tung, N | |
dc.contributor.author | van Asperen, CJ | |
dc.contributor.author | van Engelen, K | |
dc.contributor.author | van Rensburg, EJ | |
dc.contributor.author | Wang-Gohrke, S | |
dc.contributor.author | Wappenschmidt, B | |
dc.contributor.author | Weitzel, JN | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | GEMO Study Collaborators, | |
dc.contributor.author | HEBON, | |
dc.contributor.author | EMBRACE, | |
dc.contributor.author | Greene, MH | |
dc.contributor.author | Rookus, MA | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Antoniou, AC | |
dc.contributor.author | Goldgar, DE | |
dc.contributor.author | Olopade, OI | |
dc.contributor.author | Rebbeck, TR | |
dc.contributor.author | Huo, D | |
dc.date.accessioned | 2019-04-09T14:21:07Z | |
dc.date.issued | 2019-04-01 | |
dc.identifier.citation | Journal of the National Cancer Institute, 2019, 111 (4), pp. 350 - 364 | |
dc.identifier.issn | 0027-8874 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3170 | |
dc.identifier.eissn | 1460-2105 | |
dc.identifier.doi | 10.1093/jnci/djy132 | |
dc.description.abstract | BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management. | |
dc.format | Print | |
dc.format.extent | 350 - 364 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS INC | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | GEMO Study Collaborators | |
dc.subject | HEBON | |
dc.subject | EMBRACE | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | BRCA1 Protein | |
dc.subject | BRCA2 Protein | |
dc.subject | Body Mass Index | |
dc.subject | Body Height | |
dc.subject | Prognosis | |
dc.subject | Risk Factors | |
dc.subject | Mutation | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adult | |
dc.subject | Female | |
dc.subject | Mendelian Randomization Analysis | |
dc.title | Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-06-29 | |
rioxxterms.versionofrecord | 10.1093/jnci/djy132 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-04 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Journal of the National Cancer Institute | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 111 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Eeles, Rosalind | |