dc.contributor.author | Law, PJ | |
dc.contributor.author | Timofeeva, M | |
dc.contributor.author | Fernandez-Rozadilla, C | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Studd, J | |
dc.contributor.author | Fernandez-Tajes, J | |
dc.contributor.author | Farrington, S | |
dc.contributor.author | Svinti, V | |
dc.contributor.author | Palles, C | |
dc.contributor.author | Orlando, G | |
dc.contributor.author | Sud, A | |
dc.contributor.author | Holroyd, A | |
dc.contributor.author | Penegar, S | |
dc.contributor.author | Theodoratou, E | |
dc.contributor.author | Vaughan-Shaw, P | |
dc.contributor.author | Campbell, H | |
dc.contributor.author | Zgaga, L | |
dc.contributor.author | Hayward, C | |
dc.contributor.author | Campbell, A | |
dc.contributor.author | Harris, S | |
dc.contributor.author | Deary, IJ | |
dc.contributor.author | Starr, J | |
dc.contributor.author | Gatcombe, L | |
dc.contributor.author | Pinna, M | |
dc.contributor.author | Briggs, S | |
dc.contributor.author | Martin, L | |
dc.contributor.author | Jaeger, E | |
dc.contributor.author | Sharma-Oates, A | |
dc.contributor.author | East, J | |
dc.contributor.author | Leedham, S | |
dc.contributor.author | Arnold, R | |
dc.contributor.author | Johnstone, E | |
dc.contributor.author | Wang, H | |
dc.contributor.author | Kerr, D | |
dc.contributor.author | Kerr, R | |
dc.contributor.author | Maughan, T | |
dc.contributor.author | Kaplan, R | |
dc.contributor.author | Al-Tassan, N | |
dc.contributor.author | Palin, K | |
dc.contributor.author | Hänninen, UA | |
dc.contributor.author | Cajuso, T | |
dc.contributor.author | Tanskanen, T | |
dc.contributor.author | Kondelin, J | |
dc.contributor.author | Kaasinen, E | |
dc.contributor.author | Sarin, A-P | |
dc.contributor.author | Eriksson, JG | |
dc.contributor.author | Rissanen, H | |
dc.contributor.author | Knekt, P | |
dc.contributor.author | Pukkala, E | |
dc.contributor.author | Jousilahti, P | |
dc.contributor.author | Salomaa, V | |
dc.contributor.author | Ripatti, S | |
dc.contributor.author | Palotie, A | |
dc.contributor.author | Renkonen-Sinisalo, L | |
dc.contributor.author | Lepistö, A | |
dc.contributor.author | Böhm, J | |
dc.contributor.author | Mecklin, J-P | |
dc.contributor.author | Buchanan, DD | |
dc.contributor.author | Win, A-K | |
dc.contributor.author | Hopper, J | |
dc.contributor.author | Jenkins, ME | |
dc.contributor.author | Lindor, NM | |
dc.contributor.author | Newcomb, PA | |
dc.contributor.author | Gallinger, S | |
dc.contributor.author | Duggan, D | |
dc.contributor.author | Casey, G | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Jöckel, K-H | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | PRACTICAL consortium, | |
dc.contributor.author | Harkin, A | |
dc.contributor.author | Allan, K | |
dc.contributor.author | McQueen, J | |
dc.contributor.author | Paul, J | |
dc.contributor.author | Iveson, T | |
dc.contributor.author | Saunders, M | |
dc.contributor.author | Butterbach, K | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Hoffmeister, M | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Kirac, I | |
dc.contributor.author | Matošević, P | |
dc.contributor.author | Hofer, P | |
dc.contributor.author | Brezina, S | |
dc.contributor.author | Gsur, A | |
dc.contributor.author | Cheadle, JP | |
dc.contributor.author | Aaltonen, LA | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Dunlop, MG | |
dc.date.accessioned | 2019-05-22T09:31:29Z | |
dc.date.issued | 2019-05-14 | |
dc.identifier.citation | Nature communications, 2019, 10 (1), pp. 2154 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3234 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-019-09775-w | |
dc.description.abstract | Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention. | |
dc.format | Electronic | |
dc.format.extent | 2154 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | PRACTICAL consortium | |
dc.subject | Humans | |
dc.subject | Colorectal Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Inheritance Patterns | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Middle Aged | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Loci | |
dc.subject | Datasets as Topic | |
dc.title | Association analyses identify 31 new risk loci for colorectal cancer susceptibility. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-03-29 | |
rioxxterms.versionofrecord | 10.1038/s41467-019-09775-w | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-05-14 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 10 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Studd, James | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Penegar, Steven | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Houlston, Richard | |