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dc.contributor.authorLaw, PJ
dc.contributor.authorTimofeeva, M
dc.contributor.authorFernandez-Rozadilla, C
dc.contributor.authorBroderick, P
dc.contributor.authorStudd, J
dc.contributor.authorFernandez-Tajes, J
dc.contributor.authorFarrington, S
dc.contributor.authorSvinti, V
dc.contributor.authorPalles, C
dc.contributor.authorOrlando, G
dc.contributor.authorSud, A
dc.contributor.authorHolroyd, A
dc.contributor.authorPenegar, S
dc.contributor.authorTheodoratou, E
dc.contributor.authorVaughan-Shaw, P
dc.contributor.authorCampbell, H
dc.contributor.authorZgaga, L
dc.contributor.authorHayward, C
dc.contributor.authorCampbell, A
dc.contributor.authorHarris, S
dc.contributor.authorDeary, IJ
dc.contributor.authorStarr, J
dc.contributor.authorGatcombe, L
dc.contributor.authorPinna, M
dc.contributor.authorBriggs, S
dc.contributor.authorMartin, L
dc.contributor.authorJaeger, E
dc.contributor.authorSharma-Oates, A
dc.contributor.authorEast, J
dc.contributor.authorLeedham, S
dc.contributor.authorArnold, R
dc.contributor.authorJohnstone, E
dc.contributor.authorWang, H
dc.contributor.authorKerr, D
dc.contributor.authorKerr, R
dc.contributor.authorMaughan, T
dc.contributor.authorKaplan, R
dc.contributor.authorAl-Tassan, N
dc.contributor.authorPalin, K
dc.contributor.authorHänninen, UA
dc.contributor.authorCajuso, T
dc.contributor.authorTanskanen, T
dc.contributor.authorKondelin, J
dc.contributor.authorKaasinen, E
dc.contributor.authorSarin, A-P
dc.contributor.authorEriksson, JG
dc.contributor.authorRissanen, H
dc.contributor.authorKnekt, P
dc.contributor.authorPukkala, E
dc.contributor.authorJousilahti, P
dc.contributor.authorSalomaa, V
dc.contributor.authorRipatti, S
dc.contributor.authorPalotie, A
dc.contributor.authorRenkonen-Sinisalo, L
dc.contributor.authorLepistö, A
dc.contributor.authorBöhm, J
dc.contributor.authorMecklin, J-P
dc.contributor.authorBuchanan, DD
dc.contributor.authorWin, A-K
dc.contributor.authorHopper, J
dc.contributor.authorJenkins, ME
dc.contributor.authorLindor, NM
dc.contributor.authorNewcomb, PA
dc.contributor.authorGallinger, S
dc.contributor.authorDuggan, D
dc.contributor.authorCasey, G
dc.contributor.authorHoffmann, P
dc.contributor.authorNöthen, MM
dc.contributor.authorJöckel, K-H
dc.contributor.authorEaston, DF
dc.contributor.authorPharoah, PDP
dc.contributor.authorPeto, J
dc.contributor.authorCanzian, F
dc.contributor.authorSwerdlow, A
dc.contributor.authorEeles, RA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorMuir, K
dc.contributor.authorPashayan, N
dc.contributor.authorPRACTICAL consortium
dc.contributor.authorHarkin, A
dc.contributor.authorAllan, K
dc.contributor.authorMcQueen, J
dc.contributor.authorPaul, J
dc.contributor.authorIveson, T
dc.contributor.authorSaunders, M
dc.contributor.authorButterbach, K
dc.contributor.authorChang-Claude, J
dc.contributor.authorHoffmeister, M
dc.contributor.authorBrenner, H
dc.contributor.authorKirac, I
dc.contributor.authorMatošević, P
dc.contributor.authorHofer, P
dc.contributor.authorBrezina, S
dc.contributor.authorGsur, A
dc.contributor.authorCheadle, JP
dc.contributor.authorAaltonen, LA
dc.contributor.authorTomlinson, I
dc.contributor.authorHoulston, RS
dc.contributor.authorDunlop, MG
dc.date.accessioned2019-05-22T09:31:29Z
dc.date.issued2019-05-14
dc.identifier.citationNature communications, 2019, 10 (1), pp. 2154 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3234
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-019-09775-w
dc.description.abstractColorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
dc.formatElectronic
dc.format.extent2154 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectPRACTICAL consortium
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectInheritance Patterns
dc.subjectPolymorphism, Single Nucleotide
dc.subjectMiddle Aged
dc.subjectAsian Continental Ancestry Group
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectDatasets as Topic
dc.titleAssociation analyses identify 31 new risk loci for colorectal cancer susceptibility.
dc.typeJournal Article
dcterms.dateAccepted2019-03-29
rioxxterms.versionofrecord10.1038/s41467-019-09775-w
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-05-14
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume10
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamCancer Genomicsen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorSud, Amiten
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorBroderick, Peteren
dc.contributor.icrauthorStudd, Jamesen
dc.contributor.icrauthorLaw, Philipen


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