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dc.contributor.authorWu, Len_US
dc.contributor.authorShu, Xen_US
dc.contributor.authorBao, Jen_US
dc.contributor.authorGuo, Xen_US
dc.contributor.authorCRUK, BPC3, CAPS, PEGASUS consortia PRACTICALen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorZheng, Wen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2019-08-09T13:35:38Z
dc.date.issued2019-07-23en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31337649en_US
dc.identifier0008-5472.CAN-18-3997en_US
dc.identifier.citationCancer Res, 2019en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3323
dc.identifier.eissn1538-7445en_US
dc.identifier.doi10.1158/0008-5472.CAN-18-3997en_US
dc.description.abstractSeveral blood protein biomarkers have been associated with prostate cancer (PrCa) risk. However, most studies assessed only a small number of biomarkers and/or included a small sample size. To identify novel protein biomarkers of PrCa risk, we studied 79,194 cases and 61,112 controls of European ancestry, included in the PRACTICAL/ELLIPSE consortia, using genetic instruments of protein quantitative trait loci (pQTLs) for 1,478 plasma proteins. 31 proteins were associated with PrCa risk including proteins encoded by GSTP1, whose methylation level was shown previously to be associated with PrCa risk, and MSMB, SPINT2, IGF2R, and CTSS, which were previously implicated as potential target genes of PrCa risk variants identified in genome-wide association studies. 18 proteins inversely correlated and 13 positively correlated with PrCa risk. For 28 of the identified proteins, gene somatic changes of short indels, splice site, nonsense, or missense mutations were detected in PrCa patients in The Cancer Genome Atlas. Pathway enrichment analysis showed that relevant genes were significantly enriched in cancer related pathways. In conclusion, this study identifies 31 candidates of protein biomarkers for PrCa risk and provides new insights into the biology and genetics of prostate tumorigenesis.en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.titleAnalysis of over 140,000 European descendants identifies genetically-predicted blood protein biomarkers associated with prostate cancer risk.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-07-17en_US
rioxxterms.versionofrecord10.1158/0008-5472.CAN-18-3997en_US
rioxxterms.licenseref.startdate2019-07-23en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer Resen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished onlineen_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden_US


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