dc.contributor.author | Qian, F | |
dc.contributor.author | Rookus, MA | |
dc.contributor.author | Leslie, G | |
dc.contributor.author | Risch, HA | |
dc.contributor.author | Greene, MH | |
dc.contributor.author | Aalfs, CM | |
dc.contributor.author | Adank, MA | |
dc.contributor.author | Adlard, J | |
dc.contributor.author | Agnarsson, BA | |
dc.contributor.author | Ahmed, M | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Arnold, N | |
dc.contributor.author | Arun, BK | |
dc.contributor.author | Ausems, MGEM | |
dc.contributor.author | Azzollini, J | |
dc.contributor.author | Barrowdale, D | |
dc.contributor.author | Barwell, J | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Białkowska, K | |
dc.contributor.author | Bonadona, V | |
dc.contributor.author | Borde, J | |
dc.contributor.author | Borg, A | |
dc.contributor.author | Bradbury, AR | |
dc.contributor.author | Brunet, J | |
dc.contributor.author | Buys, SS | |
dc.contributor.author | Caldés, T | |
dc.contributor.author | Caligo, MA | |
dc.contributor.author | Campbell, I | |
dc.contributor.author | Carter, J | |
dc.contributor.author | Chiquette, J | |
dc.contributor.author | Chung, WK | |
dc.contributor.author | Claes, KBM | |
dc.contributor.author | Collée, JM | |
dc.contributor.author | Collonge-Rame, M-A | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Daly, MB | |
dc.contributor.author | Delnatte, C | |
dc.contributor.author | Diez, O | |
dc.contributor.author | Domchek, SM | |
dc.contributor.author | Dorfling, CM | |
dc.contributor.author | Eason, J | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Eeles, R | |
dc.contributor.author | Engel, C | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Faivre, L | |
dc.contributor.author | Feliubadaló, L | |
dc.contributor.author | Foretova, L | |
dc.contributor.author | Friedman, E | |
dc.contributor.author | Frost, D | |
dc.contributor.author | Ganz, PA | |
dc.contributor.author | Garber, J | |
dc.contributor.author | Garcia-Barberan, V | |
dc.contributor.author | Gehrig, A | |
dc.contributor.author | Glendon, G | |
dc.contributor.author | Godwin, AK | |
dc.contributor.author | Gómez Garcia, EB | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Hauke, J | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Hulick, PJ | |
dc.contributor.author | Imyanitov, EN | |
dc.contributor.author | Isaacs, C | |
dc.contributor.author | Izatt, L | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | Janavicius, R | |
dc.contributor.author | John, EM | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Kets, CM | |
dc.contributor.author | Laitman, Y | |
dc.contributor.author | Lázaro, C | |
dc.contributor.author | Leroux, D | |
dc.contributor.author | Lester, J | |
dc.contributor.author | Lesueur, F | |
dc.contributor.author | Loud, JT | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Łukomska, A | |
dc.contributor.author | McGuffog, L | |
dc.contributor.author | Mebirouk, N | |
dc.contributor.author | Meijers-Heijboer, HEJ | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Miller, A | |
dc.contributor.author | Montagna, M | |
dc.contributor.author | Mooij, TM | |
dc.contributor.author | Mouret-Fourme, E | |
dc.contributor.author | Nathanson, KL | |
dc.contributor.author | Nehoray, B | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Nielsen, FC | |
dc.contributor.author | Offit, K | |
dc.contributor.author | Olah, E | |
dc.contributor.author | Ong, K-R | |
dc.contributor.author | Oosterwijk, JC | |
dc.contributor.author | Ottini, L | |
dc.contributor.author | Parsons, MT | |
dc.contributor.author | Peterlongo, P | |
dc.contributor.author | Pfeiler, G | |
dc.contributor.author | Pradhan, N | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Ramus, SJ | |
dc.contributor.author | Rantala, J | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Robson, M | |
dc.contributor.author | Rodriguez, GC | |
dc.contributor.author | Salani, R | |
dc.contributor.author | Scheuner, MT | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Shah, PD | |
dc.contributor.author | Side, LE | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Singer, CF | |
dc.contributor.author | Steinemann, D | |
dc.contributor.author | Stoppa-Lyonnet, D | |
dc.contributor.author | Tan, YY | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Terry, MB | |
dc.contributor.author | Thomassen, M | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Tognazzo, S | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Tung, N | |
dc.contributor.author | van Asperen, CJ | |
dc.contributor.author | van Engelen, K | |
dc.contributor.author | van Rensburg, EJ | |
dc.contributor.author | Venat-Bouvet, L | |
dc.contributor.author | Vierstraete, J | |
dc.contributor.author | Wagner, G | |
dc.contributor.author | Walker, L | |
dc.contributor.author | Weitzel, JN | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | KConFab Investigators, | |
dc.contributor.author | HEBON Investigators, | |
dc.contributor.author | GEMO Study Collaborators, | |
dc.contributor.author | EMBRACE Collaborators, | |
dc.contributor.author | Antoniou, AC | |
dc.contributor.author | Goldgar, DE | |
dc.contributor.author | Olopade, OI | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Rebbeck, TR | |
dc.contributor.author | Huo, D | |
dc.contributor.author | CIMBA, | |
dc.date.accessioned | 2019-09-17T09:33:58Z | |
dc.date.issued | 2019-07-16 | |
dc.identifier.citation | British journal of cancer, 2019, 121 (2), pp. 180 - 192 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3340 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/s41416-019-0492-8 | |
dc.description.abstract | BACKGROUND: Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS: We applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS) using 586 height-associated variants and a BMI genetic score (BMI-GS) using 93 BMI-associated variants. Associations were assessed using weighted Cox models. RESULTS: Observed height was not associated with ovarian cancer risk (hazard ratio [HR]: 1.07 per 10-cm increase in height, 95% confidence interval [CI]: 0.94-1.23). Height-GS showed similar results (HR = 1.02, 95% CI: 0.85-1.23). Higher BMI was significantly associated with increased risk in premenopausal women with HR = 1.25 (95% CI: 1.06-1.48) and HR = 1.59 (95% CI: 1.08-2.33) per 5-kg/m2 increase in observed and genetically determined BMI, respectively. No association was found for postmenopausal women. Interaction between menopausal status and BMI was significant (Pinteraction < 0.05). CONCLUSION: Our observation of a positive association between BMI and ovarian cancer risk in premenopausal BRCA1/2 mutation carriers is consistent with findings in the general population. | |
dc.format | Print-Electronic | |
dc.format.extent | 180 - 192 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | KConFab Investigators | |
dc.subject | HEBON Investigators | |
dc.subject | GEMO Study Collaborators | |
dc.subject | EMBRACE Collaborators | |
dc.subject | CIMBA | |
dc.subject | Humans | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Body Mass Index | |
dc.subject | Body Height | |
dc.subject | Proportional Hazards Models | |
dc.subject | Menopause | |
dc.subject | Heterozygote | |
dc.subject | Mutation | |
dc.subject | Genes, BRCA1 | |
dc.subject | Genes, BRCA2 | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Mendelian Randomization Analysis | |
dc.title | Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-05-17 | |
rioxxterms.versionofrecord | 10.1038/s41416-019-0492-8 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | British journal of cancer | |
pubs.issue | 2 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 121 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Eeles, Rosalind | |