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dc.contributor.authorPatel, VL
dc.contributor.authorBusch, EL
dc.contributor.authorFriebel, TM
dc.contributor.authorCronin, A
dc.contributor.authorLeslie, G
dc.contributor.authorMcGuffog, L
dc.contributor.authorAdlard, J
dc.contributor.authorAgata, S
dc.contributor.authorAgnarsson, BA
dc.contributor.authorAhmed, M
dc.contributor.authorAittomäki, K
dc.contributor.authorAlducci, E
dc.contributor.authorAndrulis, IL
dc.contributor.authorArason, A
dc.contributor.authorArnold, N
dc.contributor.authorArtioli, G
dc.contributor.authorArver, B
dc.contributor.authorAuber, B
dc.contributor.authorAzzollini, J
dc.contributor.authorBalmaña, J
dc.contributor.authorBarkardottir, RB
dc.contributor.authorBarnes, DR
dc.contributor.authorBarroso, A
dc.contributor.authorBarrowdale, D
dc.contributor.authorBelotti, M
dc.contributor.authorBenitez, J
dc.contributor.authorBertelsen, B
dc.contributor.authorBlok, MJ
dc.contributor.authorBodrogi, I
dc.contributor.authorBonadona, V
dc.contributor.authorBonanni, B
dc.contributor.authorBondavalli, D
dc.contributor.authorBoonen, SE
dc.contributor.authorBorde, J
dc.contributor.authorBorg, A
dc.contributor.authorBradbury, AR
dc.contributor.authorBrady, A
dc.contributor.authorBrewer, C
dc.contributor.authorBrunet, J
dc.contributor.authorBuecher, B
dc.contributor.authorBuys, SS
dc.contributor.authorCabezas-Camarero, S
dc.contributor.authorCaldés, T
dc.contributor.authorCaliebe, A
dc.contributor.authorCaligo, MA
dc.contributor.authorCalvello, M
dc.contributor.authorCampbell, IG
dc.contributor.authorCarnevali, I
dc.contributor.authorCarrasco, E
dc.contributor.authorChan, TL
dc.contributor.authorChu, ATW
dc.contributor.authorChung, WK
dc.contributor.authorClaes, KBM
dc.contributor.authorCollaborators, GS
dc.contributor.authorCollaborators, E
dc.contributor.authorCook, J
dc.contributor.authorCortesi, L
dc.contributor.authorCouch, FJ
dc.contributor.authorDaly, MB
dc.contributor.authorDamante, G
dc.contributor.authorDarder, E
dc.contributor.authorDavidson, R
dc.contributor.authorde la Hoya, M
dc.contributor.authorPuppa, LD
dc.contributor.authorDennis, J
dc.contributor.authorDíez, O
dc.contributor.authorDing, YC
dc.contributor.authorDitsch, N
dc.contributor.authorDomchek, SM
dc.contributor.authorDonaldson, A
dc.contributor.authorDworniczak, B
dc.contributor.authorEaston, DF
dc.contributor.authorEccles, DM
dc.contributor.authorEeles, RA
dc.contributor.authorEhrencrona, H
dc.contributor.authorEjlertsen, B
dc.contributor.authorEngel, C
dc.contributor.authorEvans, DG
dc.contributor.authorFaivre, L
dc.contributor.authorFaust, U
dc.contributor.authorFeliubadaló, L
dc.contributor.authorForetova, L
dc.contributor.authorFostira, F
dc.contributor.authorFountzilas, G
dc.contributor.authorFrost, D
dc.contributor.authorGarcía-Barberán, V
dc.contributor.authorGarre, P
dc.contributor.authorGauthier-Villars, M
dc.contributor.authorGéczi, L
dc.contributor.authorGehrig, A
dc.contributor.authorGerdes, A-M
dc.contributor.authorGesta, P
dc.contributor.authorGiannini, G
dc.contributor.authorGlendon, G
dc.contributor.authorGodwin, AK
dc.contributor.authorGoldgar, DE
dc.contributor.authorGreene, MH
dc.contributor.authorGutierrez-Barrera, AM
dc.contributor.authorHahnen, E
dc.contributor.authorHamann, U
dc.contributor.authorHauke, J
dc.contributor.authorHerold, N
dc.contributor.authorHogervorst, FBL
dc.contributor.authorHonisch, E
dc.contributor.authorHopper, JL
dc.contributor.authorHulick, PJ
dc.contributor.authorInvestigators, K
dc.contributor.authorInvestigators, H
dc.contributor.authorIzatt, L
dc.contributor.authorJager, A
dc.contributor.authorJames, P
dc.contributor.authorJanavicius, R
dc.contributor.authorJensen, UB
dc.contributor.authorJensen, TD
dc.contributor.authorJohannsson, OT
dc.contributor.authorJohn, EM
dc.contributor.authorJoseph, V
dc.contributor.authorKang, E
dc.contributor.authorKast, K
dc.contributor.authorKiiski, JI
dc.contributor.authorKim, S-W
dc.contributor.authorKim, Z
dc.contributor.authorKo, K-P
dc.contributor.authorKonstantopoulou, I
dc.contributor.authorKramer, G
dc.contributor.authorKrogh, L
dc.contributor.authorKruse, TA
dc.contributor.authorKwong, A
dc.contributor.authorLarsen, M
dc.contributor.authorLasset, C
dc.contributor.authorLautrup, C
dc.contributor.authorLazaro, C
dc.contributor.authorLee, J
dc.contributor.authorLee, JW
dc.contributor.authorLee, MH
dc.contributor.authorLemke, J
dc.contributor.authorLesueur, F
dc.contributor.authorLiljegren, A
dc.contributor.authorLindblom, A
dc.contributor.authorLlovet, P
dc.contributor.authorLopez-Fernández, A
dc.contributor.authorLopez-Perolio, I
dc.contributor.authorLorca, V
dc.contributor.authorLoud, JT
dc.contributor.authorMa, ESK
dc.contributor.authorMai, PL
dc.contributor.authorManoukian, S
dc.contributor.authorMari, V
dc.contributor.authorMartin, L
dc.contributor.authorMatricardi, L
dc.contributor.authorMebirouk, N
dc.contributor.authorMedici, V
dc.contributor.authorMeijers-Heijboer, HEJ
dc.contributor.authorMeindl, A
dc.contributor.authorMensenkamp, AR
dc.contributor.authorMiller, C
dc.contributor.authorGomes, DM
dc.contributor.authorMontagna, M
dc.contributor.authorMooij, TM
dc.contributor.authorMoserle, L
dc.contributor.authorMouret-Fourme, E
dc.contributor.authorMulligan, AM
dc.contributor.authorNathanson, KL
dc.contributor.authorNavratilova, M
dc.contributor.authorNevanlinna, H
dc.contributor.authorNiederacher, D
dc.contributor.authorNielsen, FCC
dc.contributor.authorNikitina-Zake, L
dc.contributor.authorOffit, K
dc.contributor.authorOlah, E
dc.contributor.authorOlopade, OI
dc.contributor.authorOng, K-R
dc.contributor.authorOsorio, A
dc.contributor.authorOtt, C-E
dc.contributor.authorPalli, D
dc.contributor.authorPark, SK
dc.contributor.authorParsons, MT
dc.contributor.authorPedersen, IS
dc.contributor.authorPeissel, B
dc.contributor.authorPeixoto, A
dc.contributor.authorPérez-Segura, P
dc.contributor.authorPeterlongo, P
dc.contributor.authorPetersen, AH
dc.contributor.authorPorteous, ME
dc.contributor.authorPujana, MA
dc.contributor.authorRadice, P
dc.contributor.authorRamser, J
dc.contributor.authorRantala, J
dc.contributor.authorRashid, MU
dc.contributor.authorRhiem, K
dc.contributor.authorRizzolo, P
dc.contributor.authorRobson, ME
dc.contributor.authorRookus, MA
dc.contributor.authorRossing, CM
dc.contributor.authorRuddy, KJ
dc.contributor.authorSantos, C
dc.contributor.authorSaule, C
dc.contributor.authorScarpitta, R
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSchuster, H
dc.contributor.authorSenter, L
dc.contributor.authorSeynaeve, CM
dc.contributor.authorShah, PD
dc.contributor.authorSharma, P
dc.contributor.authorShin, VY
dc.contributor.authorSilvestri, V
dc.contributor.authorSimard, J
dc.contributor.authorSinger, CF
dc.contributor.authorSkytte, A-B
dc.contributor.authorSnape, K
dc.contributor.authorSolano, AR
dc.contributor.authorSoucy, P
dc.contributor.authorSouthey, MC
dc.contributor.authorSpurdle, AB
dc.contributor.authorSteele, L
dc.contributor.authorSteinemann, D
dc.contributor.authorStoppa-Lyonnet, D
dc.contributor.authorStradella, A
dc.contributor.authorSunde, L
dc.contributor.authorSutter, C
dc.contributor.authorTan, YY
dc.contributor.authorTeixeira, MR
dc.contributor.authorTeo, SH
dc.contributor.authorThomassen, M
dc.contributor.authorTibiletti, MG
dc.contributor.authorTischkowitz, M
dc.contributor.authorTognazzo, S
dc.contributor.authorToland, AE
dc.contributor.authorTommasi, S
dc.contributor.authorTorres, D
dc.contributor.authorToss, A
dc.contributor.authorTrainer, AH
dc.contributor.authorTung, N
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorvan der Baan, FH
dc.contributor.authorvan der Kolk, LE
dc.contributor.authorvan der Luijt, RB
dc.contributor.authorvan Hest, LP
dc.contributor.authorVaresco, L
dc.contributor.authorVaron-Mateeva, R
dc.contributor.authorViel, A
dc.contributor.authorVierstraete, J
dc.contributor.authorVilla, R
dc.contributor.authorvon Wachenfeldt, A
dc.contributor.authorWagner, P
dc.contributor.authorWang-Gohrke, S
dc.contributor.authorWappenschmidt, B
dc.contributor.authorWeitzel, JN
dc.contributor.authorWieme, G
dc.contributor.authorYadav, S
dc.contributor.authorYannoukakos, D
dc.contributor.authorYoon, S-Y
dc.contributor.authorZanzottera, C
dc.contributor.authorZorn, KK
dc.contributor.authorD'Amico, AV
dc.contributor.authorFreedman, ML
dc.contributor.authorPomerantz, MM
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorAntoniou, AC
dc.contributor.authorNeuhausen, SL
dc.contributor.authorOttini, L
dc.contributor.authorNielsen, HR
dc.contributor.authorRebbeck, TR
dc.date.accessioned2020-02-04T10:23:08Z
dc.date.issued2020-02
dc.identifier.citationCancer research, 2020, 80 (3), pp. 624 - 638
dc.identifier.issn0008-5472
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3505
dc.identifier.eissn1538-7445
dc.identifier.doi10.1158/0008-5472.can-19-1840
dc.description.abstractPathogenic sequence variants (PSV) in BRCA1 or BRCA2 ( BRCA1/2 ) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1 . These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
dc.formatPrint-Electronic
dc.format.extent624 - 638
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectBRCA1 Protein
dc.subjectBRCA2 Protein
dc.subjectPrognosis
dc.subjectRisk Factors
dc.subjectGenomics
dc.subjectHeterozygote
dc.subjectMutation
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectYoung Adult
dc.subjectGenetic Association Studies
dc.titleAssociation of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness.
dc.typeJournal Article
dcterms.dateAccepted2019-11-08
rioxxterms.versionofrecord10.1158/0008-5472.can-19-1840
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2020-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCancer research
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume80
pubs.embargo.termsNot known
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden


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