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dc.contributor.authorPatel, VLen_US
dc.contributor.authorBusch, ELen_US
dc.contributor.authorFriebel, TMen_US
dc.contributor.authorCronin, Aen_US
dc.contributor.authorLeslie, Gen_US
dc.contributor.authorMcGuffog, Len_US
dc.contributor.authorAdlard, Jen_US
dc.contributor.authorAgata, Sen_US
dc.contributor.authorAgnarsson, BAen_US
dc.contributor.authorAhmed, Men_US
dc.contributor.authorAittomäki, Ken_US
dc.contributor.authorAlducci, Een_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorArason, Aen_US
dc.contributor.authorArnold, Nen_US
dc.contributor.authorArtioli, Gen_US
dc.contributor.authorArver, Ben_US
dc.contributor.authorAuber, Ben_US
dc.contributor.authorAzzollini, Jen_US
dc.contributor.authorBalmaña, Jen_US
dc.contributor.authorBarkardottir, RBen_US
dc.contributor.authorBarnes, DRen_US
dc.contributor.authorBarroso, Aen_US
dc.contributor.authorBarrowdale, Den_US
dc.contributor.authorBelotti, Men_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBertelsen, Ben_US
dc.contributor.authorBlok, MJen_US
dc.contributor.authorBodrogi, Ien_US
dc.contributor.authorBonadona, Ven_US
dc.contributor.authorBonanni, Ben_US
dc.contributor.authorBondavalli, Den_US
dc.contributor.authorBoonen, SEen_US
dc.contributor.authorBorde, Jen_US
dc.contributor.authorBorg, Aen_US
dc.contributor.authorBradbury, ARen_US
dc.contributor.authorBrady, Aen_US
dc.contributor.authorBrewer, Cen_US
dc.contributor.authorBrunet, Jen_US
dc.contributor.authorBuecher, Ben_US
dc.contributor.authorBuys, SSen_US
dc.contributor.authorCabezas-Camarero, Sen_US
dc.contributor.authorCaldés, Ten_US
dc.contributor.authorCaliebe, Aen_US
dc.contributor.authorCaligo, MAen_US
dc.contributor.authorCalvello, Men_US
dc.contributor.authorCampbell, IGen_US
dc.contributor.authorCarnevali, Ien_US
dc.contributor.authorCarrasco, Een_US
dc.contributor.authorChan, TLen_US
dc.contributor.authorChu, ATWen_US
dc.contributor.authorChung, WKen_US
dc.contributor.authorClaes, KBMen_US
dc.contributor.authorCollaborators, GSen_US
dc.contributor.authorCollaborators, Een_US
dc.contributor.authorCook, Jen_US
dc.contributor.authorCortesi, Len_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorDaly, MBen_US
dc.contributor.authorDamante, Gen_US
dc.contributor.authorDarder, Een_US
dc.contributor.authorDavidson, Ren_US
dc.contributor.authorde la Hoya, Men_US
dc.contributor.authorPuppa, LDen_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorDíez, Oen_US
dc.contributor.authorDing, YCen_US
dc.contributor.authorDitsch, Nen_US
dc.contributor.authorDomchek, SMen_US
dc.contributor.authorDonaldson, Aen_US
dc.contributor.authorDworniczak, Ben_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorEccles, DMen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorEhrencrona, Hen_US
dc.contributor.authorEjlertsen, Ben_US
dc.contributor.authorEngel, Cen_US
dc.contributor.authorEvans, DGen_US
dc.contributor.authorFaivre, Len_US
dc.contributor.authorFaust, Uen_US
dc.contributor.authorFeliubadaló, Len_US
dc.contributor.authorForetova, Len_US
dc.contributor.authorFostira, Fen_US
dc.contributor.authorFountzilas, Gen_US
dc.contributor.authorFrost, Den_US
dc.contributor.authorGarcía-Barberán, Ven_US
dc.contributor.authorGarre, Pen_US
dc.contributor.authorGauthier-Villars, Men_US
dc.contributor.authorGéczi, Len_US
dc.contributor.authorGehrig, Aen_US
dc.contributor.authorGerdes, A-Men_US
dc.contributor.authorGesta, Pen_US
dc.contributor.authorGiannini, Gen_US
dc.contributor.authorGlendon, Gen_US
dc.contributor.authorGodwin, AKen_US
dc.contributor.authorGoldgar, DEen_US
dc.contributor.authorGreene, MHen_US
dc.contributor.authorGutierrez-Barrera, AMen_US
dc.contributor.authorHahnen, Een_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorHauke, Jen_US
dc.contributor.authorHerold, Nen_US
dc.contributor.authorHogervorst, FBLen_US
dc.contributor.authorHonisch, Een_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorHulick, PJen_US
dc.contributor.authorInvestigators, Ken_US
dc.contributor.authorInvestigators, Hen_US
dc.contributor.authorIzatt, Len_US
dc.contributor.authorJager, Aen_US
dc.contributor.authorJames, Pen_US
dc.contributor.authorJanavicius, Ren_US
dc.contributor.authorJensen, UBen_US
dc.contributor.authorJensen, TDen_US
dc.contributor.authorJohannsson, OTen_US
dc.contributor.authorJohn, EMen_US
dc.contributor.authorJoseph, Ven_US
dc.contributor.authorKang, Een_US
dc.contributor.authorKast, Ken_US
dc.contributor.authorKiiski, JIen_US
dc.contributor.authorKim, S-Wen_US
dc.contributor.authorKim, Zen_US
dc.contributor.authorKo, K-Pen_US
dc.contributor.authorKonstantopoulou, Ien_US
dc.contributor.authorKramer, Gen_US
dc.contributor.authorKrogh, Len_US
dc.contributor.authorKruse, TAen_US
dc.contributor.authorKwong, Aen_US
dc.contributor.authorLarsen, Men_US
dc.contributor.authorLasset, Cen_US
dc.contributor.authorLautrup, Cen_US
dc.contributor.authorLazaro, Cen_US
dc.contributor.authorLee, Jen_US
dc.contributor.authorLee, JWen_US
dc.contributor.authorLee, MHen_US
dc.contributor.authorLemke, Jen_US
dc.contributor.authorLesueur, Fen_US
dc.contributor.authorLiljegren, Aen_US
dc.contributor.authorLindblom, Aen_US
dc.contributor.authorLlovet, Pen_US
dc.contributor.authorLopez-Fernández, Aen_US
dc.contributor.authorLopez-Perolio, Ien_US
dc.contributor.authorLorca, Ven_US
dc.contributor.authorLoud, JTen_US
dc.contributor.authorMa, ESKen_US
dc.contributor.authorMai, PLen_US
dc.contributor.authorManoukian, Sen_US
dc.contributor.authorMari, Ven_US
dc.contributor.authorMartin, Len_US
dc.contributor.authorMatricardi, Len_US
dc.contributor.authorMebirouk, Nen_US
dc.contributor.authorMedici, Ven_US
dc.contributor.authorMeijers-Heijboer, HEJen_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorMensenkamp, ARen_US
dc.contributor.authorMiller, Cen_US
dc.contributor.authorGomes, DMen_US
dc.contributor.authorMontagna, Men_US
dc.contributor.authorMooij, TMen_US
dc.contributor.authorMoserle, Len_US
dc.contributor.authorMouret-Fourme, Een_US
dc.contributor.authorMulligan, AMen_US
dc.contributor.authorNathanson, KLen_US
dc.contributor.authorNavratilova, Men_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorNiederacher, Den_US
dc.contributor.authorNielsen, FCCen_US
dc.contributor.authorNikitina-Zake, Len_US
dc.contributor.authorOffit, Ken_US
dc.contributor.authorOlah, Een_US
dc.contributor.authorOlopade, OIen_US
dc.contributor.authorOng, K-Ren_US
dc.contributor.authorOsorio, Aen_US
dc.contributor.authorOtt, C-Een_US
dc.contributor.authorPalli, Den_US
dc.contributor.authorPark, SKen_US
dc.contributor.authorParsons, MTen_US
dc.contributor.authorPedersen, ISen_US
dc.contributor.authorPeissel, Ben_US
dc.contributor.authorPeixoto, Aen_US
dc.contributor.authorPérez-Segura, Pen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorPetersen, AHen_US
dc.contributor.authorPorteous, MEen_US
dc.contributor.authorPujana, MAen_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorRamser, Jen_US
dc.contributor.authorRantala, Jen_US
dc.contributor.authorRashid, MUen_US
dc.contributor.authorRhiem, Ken_US
dc.contributor.authorRizzolo, Pen_US
dc.contributor.authorRobson, MEen_US
dc.contributor.authorRookus, MAen_US
dc.contributor.authorRossing, CMen_US
dc.contributor.authorRuddy, KJen_US
dc.contributor.authorSantos, Cen_US
dc.contributor.authorSaule, Cen_US
dc.contributor.authorScarpitta, Ren_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorSchuster, Hen_US
dc.contributor.authorSenter, Len_US
dc.contributor.authorSeynaeve, CMen_US
dc.contributor.authorShah, PDen_US
dc.contributor.authorSharma, Pen_US
dc.contributor.authorShin, VYen_US
dc.contributor.authorSilvestri, Ven_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorSinger, CFen_US
dc.contributor.authorSkytte, A-Ben_US
dc.contributor.authorSnape, Ken_US
dc.contributor.authorSolano, ARen_US
dc.contributor.authorSoucy, Pen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSpurdle, ABen_US
dc.contributor.authorSteele, Len_US
dc.contributor.authorSteinemann, Den_US
dc.contributor.authorStoppa-Lyonnet, Den_US
dc.contributor.authorStradella, Aen_US
dc.contributor.authorSunde, Len_US
dc.contributor.authorSutter, Cen_US
dc.contributor.authorTan, YYen_US
dc.contributor.authorTeixeira, MRen_US
dc.contributor.authorTeo, SHen_US
dc.contributor.authorThomassen, Men_US
dc.contributor.authorTibiletti, MGen_US
dc.contributor.authorTischkowitz, Men_US
dc.contributor.authorTognazzo, Sen_US
dc.contributor.authorToland, AEen_US
dc.contributor.authorTommasi, Sen_US
dc.contributor.authorTorres, Den_US
dc.contributor.authorToss, Aen_US
dc.contributor.authorTrainer, AHen_US
dc.contributor.authorTung, Nen_US
dc.contributor.authorvan Asperen, CJen_US
dc.contributor.authorvan der Baan, FHen_US
dc.contributor.authorvan der Kolk, LEen_US
dc.contributor.authorvan der Luijt, RBen_US
dc.contributor.authorvan Hest, LPen_US
dc.contributor.authorVaresco, Len_US
dc.contributor.authorVaron-Mateeva, Ren_US
dc.contributor.authorViel, Aen_US
dc.contributor.authorVierstraete, Jen_US
dc.contributor.authorVilla, Ren_US
dc.contributor.authorvon Wachenfeldt, Aen_US
dc.contributor.authorWagner, Pen_US
dc.contributor.authorWang-Gohrke, Sen_US
dc.contributor.authorWappenschmidt, Ben_US
dc.contributor.authorWeitzel, JNen_US
dc.contributor.authorWieme, Gen_US
dc.contributor.authorYadav, Sen_US
dc.contributor.authorYannoukakos, Den_US
dc.contributor.authorYoon, S-Yen_US
dc.contributor.authorZanzottera, Cen_US
dc.contributor.authorZorn, KKen_US
dc.contributor.authorD'Amico, AVen_US
dc.contributor.authorFreedman, MLen_US
dc.contributor.authorPomerantz, MMen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorAntoniou, ACen_US
dc.contributor.authorNeuhausen, SLen_US
dc.contributor.authorOttini, Len_US
dc.contributor.authorNielsen, HRen_US
dc.contributor.authorRebbeck, TRen_US
dc.date.accessioned2020-02-04T10:23:08Z
dc.date.issued2020-02en_US
dc.identifier.citationCancer research, 2020, 80 (3), pp. 624 - 638en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3505
dc.identifier.eissn1538-7445en_US
dc.identifier.doi10.1158/0008-5472.can-19-1840en_US
dc.description.abstractPathogenic sequence variants (PSV) in <i>BRCA1</i> or <i>BRCA2</i> (<i>BRCA1/2</i>) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in <i>BRCA1/2</i> were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 <i>BRCA1</i> and 171 <i>BRCA2</i> male PSV carriers with prostate cancer, and 3,388 <i>BRCA1</i> and 2,880 <i>BRCA2</i> male PSV carriers without prostate cancer. PSVs in the 3' region of <i>BRCA2</i> (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; <i>P</i> = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; <i>P</i> = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; <i>P</i> = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; <i>P</i> = 0.0002). No genotype-phenotype associations were detected for PSVs in <i>BRCA1</i>. These results demonstrate that specific <i>BRCA2</i> PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.en_US
dc.formatPrint-Electronicen_US
dc.format.extent624 - 638en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
dc.subjectHumansen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectBRCA1 Proteinen_US
dc.subjectBRCA2 Proteinen_US
dc.subjectPrognosisen_US
dc.subjectRisk Factorsen_US
dc.subjectGenomicsen_US
dc.subjectHeterozygoteen_US
dc.subjectMutationen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectMiddle Ageden_US
dc.subjectMaleen_US
dc.subjectYoung Adulten_US
dc.subjectGenetic Association Studiesen_US
dc.titleAssociation of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-11-08en_US
rioxxterms.versionofrecord10.1158/0008-5472.can-19-1840en_US
rioxxterms.licenseref.startdate2020-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer researchen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublisheden_US
pubs.volume80en_US
pubs.embargo.termsNot knownen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorEeles, Rosalinden_US


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