Show simple item record

dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorNichols, HBen_US
dc.contributor.authorWright, LBen_US
dc.contributor.authorBrook, MNen_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorO'Brien, KMen_US
dc.contributor.authorAdami, H-Oen_US
dc.contributor.authorBaglietto, Len_US
dc.contributor.authorBernstein, Len_US
dc.contributor.authorBertrand, KAen_US
dc.contributor.authorBoutron-Ruault, M-Cen_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorConnor, AEen_US
dc.contributor.authorDossus, Len_US
dc.contributor.authorEliassen, AHen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGram, ITen_US
dc.contributor.authorHankinson, SEen_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorKey, TJen_US
dc.contributor.authorKirsh, VAen_US
dc.contributor.authorKitahara, CMen_US
dc.contributor.authorLarsson, SCen_US
dc.contributor.authorLinet, Men_US
dc.contributor.authorMa, Hen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorOzasa, Ken_US
dc.contributor.authorPalmer, JRen_US
dc.contributor.authorRiboli, Een_US
dc.contributor.authorRohan, TEen_US
dc.contributor.authorSacerdote, Cen_US
dc.contributor.authorSadakane, Aen_US
dc.contributor.authorSund, Men_US
dc.contributor.authorTamimi, RMen_US
dc.contributor.authorTrichopoulou, Aen_US
dc.contributor.authorUrsin, Gen_US
dc.contributor.authorVisvanathan, Ken_US
dc.contributor.authorWeiderpass, Een_US
dc.contributor.authorWillett, WCen_US
dc.contributor.authorWolk, Aen_US
dc.contributor.authorZeleniuch-Jacquotte, Aen_US
dc.contributor.authorSandler, DPen_US
dc.contributor.authorSwerdlow, AJen_US
dc.date.accessioned2020-03-04T10:38:01Z
dc.date.issued2020-02-03en_US
dc.identifier.citationInternational journal of cancer, 2020en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3527
dc.identifier.eissn1097-0215en_US
dc.identifier.doi10.1002/ijc.32892en_US
dc.description.abstractEarly-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.en_US
dc.formatPrint-Electronicen_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleAdult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-01-03en_US
rioxxterms.versionofrecord10.1002/ijc.32892en_US
rioxxterms.licenseref.startdate2020-02-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfInternational journal of canceren_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublisheden_US
pubs.embargo.termsNot knownen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorBrook, Marken_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorWright, Laurenen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/