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dc.contributor.authorGrünwald, Ven_US
dc.contributor.authorChirovsky, Den_US
dc.contributor.authorCheung, WYen_US
dc.contributor.authorBertolini, Fen_US
dc.contributor.authorAhn, M-Jen_US
dc.contributor.authorYang, M-Hen_US
dc.contributor.authorCastro, Gen_US
dc.contributor.authorBerrocal, Aen_US
dc.contributor.authorSjoquist, Ken_US
dc.contributor.authorKuyas, Hen_US
dc.contributor.authorAuclair, Ven_US
dc.contributor.authorGuillaume, Xen_US
dc.contributor.authorJoo, Sen_US
dc.contributor.authorShah, Ren_US
dc.contributor.authorHarrington, Ken_US
dc.contributor.authorGLANCE H&N STUDY Investigatorsen_US
dc.date.accessioned2020-04-02T15:02:14Z
dc.date.issued2020-03en_US
dc.identifier.citationOral oncology, 2020, 102 pp. 104526 - ?en_US
dc.identifier.issn1368-8375en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3577
dc.identifier.eissn1879-0593en_US
dc.identifier.doi10.1016/j.oraloncology.2019.104526en_US
dc.description.abstractOBJECTIVES:Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and survival outcomes for R/M HNSCC in the real-world setting. MATERIALS AND METHODS:A multi-site retrospective chart review was conducted in Europe (Germany, United Kingdom, Italy, Spain), Asia Pacific (Australia, South Korea, Taiwan), and Latin/North America (Brazil and Canada) to identify patients who initiated first-line systemic therapy for R/M HNSCC between January 2011 and December 2013. Patients were followed through December 2015 to collect clinical characteristics, treatment and survival data. RESULTS:Among 733 R/M HNSCC patients across 71 sites, median age was 60 years (inter-quartile range 54-67), 84% male, and 70% Eastern Cooperative Oncology Group performance status 0-1; 32% had oral cavity and 30% oropharyngeal cancers. The most common first-line regimen across all countries consisted of platinum-based combinations (73%), including platinum + 5-fluorouracil (5-FU) (26%), cetuximab + platinum ± 5-FU (22%), or taxane + platinum ± 5-FU (16%). However, use of different platinum-based combinations varied substantially; administration of cetuximab + platinum ± 5-FU was frequent in Italy (81%), Germany (46%) and Spain (38%), whereas use in other countries was limited. Median follow-up was 22.6 months (95% confidence interval [CI]: 21.5-24.6 months). Median real-world overall survival was only 8.0 months (95% CI: 7.0-8.0), with one-year survival reaching only 30.9% (95% CI: 27.5-34.3). CONCLUSION:Systemic therapies used in clinical practice for patients with R/M HNSCC vary substantially across countries. Prognosis remains poor in this patient population, highlighting the need for newer, more efficacious treatments.en_US
dc.formatPrint-Electronicen_US
dc.format.extent104526 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectGLANCE H&N STUDY Investigatorsen_US
dc.titleGlobal treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-12-13en_US
rioxxterms.versionofrecord10.1016/j.oraloncology.2019.104526en_US
rioxxterms.licenseref.startdate2020-03en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfOral oncologyen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.publication-statusPublisheden_US
pubs.volume102en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorHarrington, Kevinen


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