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dc.contributor.authorLoveday, Cen_US
dc.contributor.authorLitchfield, Ken_US
dc.contributor.authorProszek, PZen_US
dc.contributor.authorCornish, AJen_US
dc.contributor.authorSanto, Fen_US
dc.contributor.authorLevy, Men_US
dc.contributor.authorMacintyre, Gen_US
dc.contributor.authorHolryod, Aen_US
dc.contributor.authorBroderick, Pen_US
dc.contributor.authorDudakia, Den_US
dc.contributor.authorBenton, Ben_US
dc.contributor.authorBakir, MAen_US
dc.contributor.authorHiley, Cen_US
dc.contributor.authorGrist, Een_US
dc.contributor.authorSwanton, Cen_US
dc.contributor.authorHuddart, Ren_US
dc.contributor.authorPowles, Ten_US
dc.contributor.authorChowdhury, Sen_US
dc.contributor.authorShipley, Jen_US
dc.contributor.authorO'Connor, Sen_US
dc.contributor.authorBrenton, JDen_US
dc.contributor.authorReid, Aen_US
dc.contributor.authorde Castro, DGen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorTurnbull, Cen_US
dc.date.accessioned2020-05-18T14:15:34Z
dc.date.issued2020-05-04en_US
dc.identifier.citationNature communications, 2020, 11 (1), pp. 2189 - ?en_US
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3613
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/s41467-020-15768-xen_US
dc.description.abstractWhile most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tumours from 26 cases with platinum-resistant TGCT, and combine this with published genomic data on an additional 624 TGCTs. We integrate analyses for driver mutations, mutational burden, global, arm-level and focal copy number (CN) events, and SNV and CN signatures. Albeit preliminary and observational in nature, these analyses provide support for a possible mechanistic link between early driver mutations in RAS and KIT and the widespread copy number events by which TGCT is characterised.en_US
dc.formatElectronicen_US
dc.format.extent2189 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleGenomic landscape of platinum resistant and sensitive testicular cancers.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-03-23en_US
rioxxterms.versionofrecord10.1038/s41467-020-15768-xen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2020-05-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature communicationsen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Sarcoma Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Sarcoma Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusPublisheden_US
pubs.volume11en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular & Population Geneticsen_US
icr.researchteamSarcoma Molecular Pathologyen_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
dc.contributor.icrauthorHoulston, Richarden_US
dc.contributor.icrauthorHuddart, Roberten_US
dc.contributor.icrauthorBroderick, Peteren_US
dc.contributor.icrauthorTurnbull, Clareen_US
dc.contributor.icrauthorShipley, Janeten_US


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