dc.contributor.author | Khalique, S | |
dc.contributor.author | Lord, CJ | |
dc.contributor.author | Banerjee, S | |
dc.contributor.author | Natrajan, R | |
dc.date.accessioned | 2020-05-27T14:13:41Z | |
dc.date.issued | 2020-04-01 | |
dc.identifier.citation | Seminars in cancer biology, 2020, 61 pp. 121 - 131 | |
dc.identifier.issn | 1044-579X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3638 | |
dc.identifier.eissn | 1096-3650 | |
dc.identifier.doi | 10.1016/j.semcancer.2019.10.025 | |
dc.description.abstract | Ovarian clear cell carcinomas (OCCC) are rare aggressive, chemo-resistant tumours comprising approximately 13% of all epithelial ovarian cancers, which have distinct clinical and molecular features, when compared to other gynaecological malignancies. At present, there are no specific licensed targeted therapies for OCCC, although a number of candidate targets have been identified. This review focuses on recent knowledge underpinning our understanding of the pathogenesis of OCCC including direct and synthetic-lethal therapeutic strategies in particular focussing on ARID1A deficiency. We also discuss current targeted clinical trials and immunotherapeutic approaches. | |
dc.format | Print-Electronic | |
dc.format.extent | 121 - 131 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Adenocarcinoma, Clear Cell | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Neovascularization, Pathologic | |
dc.subject | DNA-Binding Proteins | |
dc.subject | Transcription Factors | |
dc.subject | Genomics | |
dc.subject | Signal Transduction | |
dc.subject | Epigenesis, Genetic | |
dc.subject | Mutation | |
dc.subject | Disease Management | |
dc.subject | Female | |
dc.subject | Genetic Association Studies | |
dc.subject | DNA Copy Number Variations | |
dc.subject | Translational Medical Research | |
dc.subject | Biomarkers | |
dc.subject | Carcinoma, Ovarian Epithelial | |
dc.title | Translational genomics of ovarian clear cell carcinoma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-10-31 | |
rioxxterms.versionofrecord | 10.1016/j.semcancer.2019.10.025 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2020-04 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Seminars in cancer biology | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 61 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Functional Genomics | |
icr.researchteam | Gene Function | |
dc.contributor.icrauthor | Lord, Christopher | |
dc.contributor.icrauthor | Natrajan, Rachael | |