Translational genomics of ovarian clear cell carcinoma.
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Ovarian clear cell carcinomas (OCCC) are rare aggressive, chemo-resistant tumours comprising approximately 13% of all epithelial ovarian cancers, which have distinct clinical and molecular features, when compared to other gynaecological malignancies. At present, there are no specific licensed targeted therapies for OCCC, although a number of candidate targets have been identified. This review focuses on recent knowledge underpinning our understanding of the pathogenesis of OCCC including direct and synthetic-lethal therapeutic strategies in particular focussing on ARID1A deficiency. We also discuss current targeted clinical trials and immunotherapeutic approaches.
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Adenocarcinoma, Clear Cell
Genetic Predisposition to Disease
Genetic Association Studies
DNA Copy Number Variations
Translational Medical Research
Carcinoma, Ovarian Epithelial
License start date
Seminars in cancer biology, 2020, 61 pp. 121 - 131