Translational genomics of ovarian clear cell carcinoma.
View/ Open
Publication Date
2020-04Author
Khalique, S
Lord, CJ
Banerjee, S
Natrajan, R
Type
Journal Article
Metadata
Show full item recordAbstract
Ovarian clear cell carcinomas (OCCC) are rare aggressive, chemo-resistant tumours comprising approximately 13% of all epithelial ovarian cancers, which have distinct clinical and molecular features, when compared to other gynaecological malignancies. At present, there are no specific licensed targeted therapies for OCCC, although a number of candidate targets have been identified. This review focuses on recent knowledge underpinning our understanding of the pathogenesis of OCCC including direct and synthetic-lethal therapeutic strategies in particular focussing on ARID1A deficiency. We also discuss current targeted clinical trials and immunotherapeutic approaches.
Collections
Licenseref URL
http://creativecommons.org/licenses/by/4.0/Version of record
Subject
Humans
Adenocarcinoma, Clear Cell
Genetic Predisposition to Disease
Neovascularization, Pathologic
DNA-Binding Proteins
Transcription Factors
Genomics
Signal Transduction
Epigenesis, Genetic
Mutation
Disease Management
Female
Genetic Association Studies
DNA Copy Number Variations
Translational Medical Research
Biomarkers
Carcinoma, Ovarian Epithelial
Research team
Functional Genomics
Gene Function
Language
eng
Date accepted
2019-10-31
License start date
2020-04
Citation
Seminars in cancer biology, 2020, 61 pp. 121 - 131