Translational genomics of ovarian clear cell carcinoma.
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Ovarian clear cell carcinomas (OCCC) are rare aggressive, chemo-resistant tumours comprising approximately 13% of all epithelial ovarian cancers, which have distinct clinical and molecular features, when compared to other gynaecological malignancies. At present, there are no specific licensed targeted therapies for OCCC, although a number of candidate targets have been identified. This review focuses on recent knowledge underpinning our understanding of the pathogenesis of OCCC including direct and synthetic-lethal therapeutic strategies in particular focussing on ARID1A deficiency. We also discuss current targeted clinical trials and immunotherapeutic approaches.
Adenocarcinoma, Clear Cell
Genetic Predisposition to Disease
Genetic Association Studies
DNA Copy Number Variations
Translational Medical Research
Carcinoma, Ovarian Epithelial
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Seminars in cancer biology, 2020, 61 pp. 121 - 131