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dc.contributor.authorGodin-Heymann, N
dc.contributor.authorBrabetz, S
dc.contributor.authorMurillo, MM
dc.contributor.authorSaponaro, M
dc.contributor.authorSantos, CR
dc.contributor.authorLobley, A
dc.contributor.authorEast, P
dc.contributor.authorChakravarty, P
dc.contributor.authorMatthews, N
dc.contributor.authorKelly, G
dc.contributor.authorJordan, S
dc.contributor.authorCastellano, E
dc.contributor.authorDownward, J
dc.date.accessioned2020-06-22T15:47:25Z
dc.date.issued2016-06
dc.identifier.citationOncogene, 2016, 35 (25), pp. 3324 - 3334
dc.identifier.issn0950-9232
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3764
dc.identifier.eissn1476-5594
dc.identifier.doi10.1038/onc.2015.394
dc.description.abstractSuppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.
dc.formatPrint-Electronic
dc.format.extent3324 - 3334
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectCell Line, Tumor
dc.subjectAnimals
dc.subjectMice, Inbred NOD
dc.subjectMice, Knockout
dc.subjectHumans
dc.subjectMice, SCID
dc.subjectLung Neoplasms
dc.subjectNeoplasm Metastasis
dc.subjectTumor Suppressor Proteins
dc.subjectTransplantation, Heterologous
dc.subjectFlow Cytometry
dc.subjectSurvival Analysis
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectCell Cycle
dc.subjectAnoikis
dc.subjectCell Proliferation
dc.subjectDown-Regulation
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectRNA Interference
dc.subjectKruppel-Like Transcription Factors
dc.subjectA549 Cells
dc.titleTumour-suppression function of KLF12 through regulation of anoikis.
dc.typeJournal Article
dcterms.dateAccepted2015-09-05
rioxxterms.versionofrecord10.1038/onc.2015.394
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfOncogene
pubs.issue25
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Lung Cancer Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Lung Cancer Group
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Lung Cancer Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Lung Cancer Group
pubs.publication-statusPublished
pubs.volume35
pubs.embargo.termsNot known
icr.researchteamLung Cancer Groupen_US
dc.contributor.icrauthorDownward, Julian David Harryen


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