dc.contributor.author | Godin-Heymann, N | |
dc.contributor.author | Brabetz, S | |
dc.contributor.author | Murillo, MM | |
dc.contributor.author | Saponaro, M | |
dc.contributor.author | Santos, CR | |
dc.contributor.author | Lobley, A | |
dc.contributor.author | East, P | |
dc.contributor.author | Chakravarty, P | |
dc.contributor.author | Matthews, N | |
dc.contributor.author | Kelly, G | |
dc.contributor.author | Jordan, S | |
dc.contributor.author | Castellano, E | |
dc.contributor.author | Downward, J | |
dc.date.accessioned | 2020-06-22T15:47:25Z | |
dc.date.issued | 2016-06 | |
dc.identifier.citation | Oncogene, 2016, 35 (25), pp. 3324 - 3334 | |
dc.identifier.issn | 0950-9232 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3764 | |
dc.identifier.eissn | 1476-5594 | |
dc.identifier.doi | 10.1038/onc.2015.394 | |
dc.description.abstract | Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion. Knockdown of KLF12 in parental cells results in decreased apoptosis following cell detachment from matrix. KLF12 regulates anoikis by promoting the cell cycle transition through S phase and therefore cell proliferation. Reduced expression levels of KLF12 results in increased ability of lung cancer cells to form tumours in vivo and is associated with poorer survival in lung cancer patients. We therefore identify KLF12 as a novel metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle. | |
dc.format | Print-Electronic | |
dc.format.extent | 3324 - 3334 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Cell Line, Tumor | |
dc.subject | Animals | |
dc.subject | Mice, Inbred NOD | |
dc.subject | Mice, Knockout | |
dc.subject | Humans | |
dc.subject | Mice, SCID | |
dc.subject | Lung Neoplasms | |
dc.subject | Neoplasm Metastasis | |
dc.subject | Tumor Suppressor Proteins | |
dc.subject | Transplantation, Heterologous | |
dc.subject | Flow Cytometry | |
dc.subject | Survival Analysis | |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | |
dc.subject | Cell Cycle | |
dc.subject | Anoikis | |
dc.subject | Cell Proliferation | |
dc.subject | Down-Regulation | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | RNA Interference | |
dc.subject | Kruppel-Like Transcription Factors | |
dc.subject | A549 Cells | |
dc.title | Tumour-suppression function of KLF12 through regulation of anoikis. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2015-09-05 | |
rioxxterms.versionofrecord | 10.1038/onc.2015.394 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-06 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Oncogene | |
pubs.issue | 25 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Lung Cancer Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Lung Cancer Group | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Lung Cancer Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Lung Cancer Group | |
pubs.publication-status | Published | |
pubs.volume | 35 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Lung Cancer Group | |
dc.contributor.icrauthor | Downward, Julian David Harry | |