dc.contributor.author | Patel, R | |
dc.contributor.author | Barker, HE | |
dc.contributor.author | Kyula, J | |
dc.contributor.author | McLaughlin, M | |
dc.contributor.author | Dillon, MT | |
dc.contributor.author | Schick, U | |
dc.contributor.author | Hafsi, H | |
dc.contributor.author | Thompson, A | |
dc.contributor.author | Khoo, V | |
dc.contributor.author | Harrington, K | |
dc.contributor.author | Zaidi, S | |
dc.date.accessioned | 2017-01-06T11:22:39Z | |
dc.date.issued | 2017-03 | |
dc.identifier.citation | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017, 122 (3), pp. 470 - 475 | |
dc.identifier.issn | 0167-8140 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/378 | |
dc.identifier.eissn | 1879-0887 | |
dc.identifier.doi | 10.1016/j.radonc.2016.12.026 | |
dc.description.abstract | Purpose Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, their clinical progress has been hampered by low bioavailability and off-target toxicities.Materials and methods We characterized the radiosensitizing activity of CCT244747, the first orally bioavailable Chk1 inhibitor. We used a panel of bladder and head and neck cancer cell lines and monitored the effect of combining CCT244747 with radiation both in in vitro and in vivo models.Results CCT244747 sensitized cancer cell lines to radiation in vitro and resulted in a growth delay in cancer xenograft models associated with a survival benefit. Radiosensitization was elicited by abrogation of the radiation-induced G2 arrest and premature entry into mitosis.Conclusions CCT244747 is a potent and specific Chk1 inhibitor that can be administered orally. It radiosensitizes tumour cell lines and represents a new therapy for clinical application in combination with radiotherapy. | |
dc.format | Print-Electronic | |
dc.format.extent | 470 - 475 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.subject | Cell Line, Tumor | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Head and Neck Neoplasms | |
dc.subject | Aminopyridines | |
dc.subject | Pyrimidines | |
dc.subject | Histones | |
dc.subject | Radiation-Sensitizing Agents | |
dc.subject | Administration, Oral | |
dc.subject | Female | |
dc.subject | Urinary Bladder Neoplasms | |
dc.subject | G2 Phase Cell Cycle Checkpoints | |
dc.subject | Checkpoint Kinase 1 | |
dc.title | An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-12-22 | |
rioxxterms.versionofrecord | 10.1016/j.radonc.2016.12.026 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.licenseref.startdate | 2017-03 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | |
pubs.issue | 3 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 122 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Targeted Therapy | en_US |
dc.contributor.icrauthor | Patel, Radhika | |
dc.contributor.icrauthor | McLaughlin, Martin | |
dc.contributor.icrauthor | Dillon, Magnus | |
dc.contributor.icrauthor | Harrington, Kevin | |
dc.contributor.icrauthor | Zaidi, Shane Haider | |
dc.contributor.icrauthor | Marsden, | |