Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
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We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this group died of rapidly progressive disease postrelapse. To study this interaction, we investigated a transgenic model of MYCN-driven medulloblastoma and found spontaneous development of Trp53 inactivating mutations. Abrogation of p53 function in this model produced aggressive tumors that mimicked characteristics of relapsed human tumors with combined P53-MYC dysfunction. Restoration of p53 activity and genetic and therapeutic suppression of MYCN all reduced tumor growth and prolonged survival. Our findings identify P53-MYC interactions at medulloblastoma relapse as biomarkers of clinically aggressive disease that may be targeted therapeutically.
Version of record
Neoplasm Recurrence, Local
Proto-Oncogene Proteins c-myc
Molecular Sequence Data
Tumor Suppressor Protein p53
N-Myc Proto-Oncogene Protein
Clinical Pharmacology & Trials (including Drug Metabolism & Pharmacokinetics Group)
Paediatric Solid Tumour Biology and Therapeutics
License start date
Cancer cell, 2015, 27 (1), pp. 72 - 84
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0
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