dc.contributor.author | Mitchell, JS | |
dc.contributor.author | Li, N | |
dc.contributor.author | Weinhold, N | |
dc.contributor.author | Försti, A | |
dc.contributor.author | Ali, M | |
dc.contributor.author | van Duin, M | |
dc.contributor.author | Thorleifsson, G | |
dc.contributor.author | Johnson, DC | |
dc.contributor.author | Chen, B | |
dc.contributor.author | Halvarsson, B-M | |
dc.contributor.author | Gudbjartsson, DF | |
dc.contributor.author | Kuiper, R | |
dc.contributor.author | Stephens, OW | |
dc.contributor.author | Bertsch, U | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Campo, C | |
dc.contributor.author | Einsele, H | |
dc.contributor.author | Gregory, WA | |
dc.contributor.author | Gullberg, U | |
dc.contributor.author | Henrion, M | |
dc.contributor.author | Hillengass, J | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Jackson, GH | |
dc.contributor.author | Johnsson, E | |
dc.contributor.author | Jöud, M | |
dc.contributor.author | Kristinsson, SY | |
dc.contributor.author | Lenhoff, S | |
dc.contributor.author | Lenive, O | |
dc.contributor.author | Mellqvist, U-H | |
dc.contributor.author | Migliorini, G | |
dc.contributor.author | Nahi, H | |
dc.contributor.author | Nelander, S | |
dc.contributor.author | Nickel, J | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Rafnar, T | |
dc.contributor.author | Ross, FM | |
dc.contributor.author | da Silva Filho, MI | |
dc.contributor.author | Swaminathan, B | |
dc.contributor.author | Thomsen, H | |
dc.contributor.author | Turesson, I | |
dc.contributor.author | Vangsted, A | |
dc.contributor.author | Vogel, U | |
dc.contributor.author | Waage, A | |
dc.contributor.author | Walker, BA | |
dc.contributor.author | Wihlborg, A-K | |
dc.contributor.author | Broyl, A | |
dc.contributor.author | Davies, FE | |
dc.contributor.author | Thorsteinsdottir, U | |
dc.contributor.author | Langer, C | |
dc.contributor.author | Hansson, M | |
dc.contributor.author | Kaiser, M | |
dc.contributor.author | Sonneveld, P | |
dc.contributor.author | Stefansson, K | |
dc.contributor.author | Morgan, GJ | |
dc.contributor.author | Goldschmidt, H | |
dc.contributor.author | Hemminki, K | |
dc.contributor.author | Nilsson, B | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2017-02-01T12:10:48Z | |
dc.date.issued | 2016-07-01 | |
dc.identifier.citation | Nature communications, 2016, 7 pp. 12050 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/396 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/ncomms12050 | |
dc.description.abstract | Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (rs9372120, P=9.09 × 10(-15)), 7q36.1 (rs7781265, P=9.71 × 10(-9)), 8q24.21 (rs1948915, P=4.20 × 10(-11)), 9p21.3 (rs2811710, P=1.72 × 10(-13)), 10p12.1 (rs2790457, P=1.77 × 10(-8)), 16q23.1 (rs7193541, P=5.00 × 10(-12)) and 20q13.13 (rs6066835, P=1.36 × 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development. | |
dc.format | Electronic | |
dc.format.extent | 12050 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Multiple Myeloma | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Ubiquitin-Protein Ligases | |
dc.subject | Adaptor Proteins, Signal Transducing | |
dc.subject | Guanine Nucleotide Exchange Factors | |
dc.subject | Transcription Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Cyclin-Dependent Kinase Inhibitor p16 | |
dc.subject | Cyclin-Dependent Kinase Inhibitor p18 | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Polycomb Repressive Complex 2 | |
dc.subject | RNA, Long Noncoding | |
dc.subject | Autophagy-Related Protein 5 | |
dc.title | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-05-24 | |
rioxxterms.versionofrecord | 10.1038/ncomms12050 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.publication-status | Published | |
pubs.volume | 7 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Molecular & Population Genetics | |
icr.researchteam | Myeloma Group | |
dc.contributor.icrauthor | Li, Ni | |
dc.contributor.icrauthor | Johnson, David | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Kaiser, Martin | |
dc.contributor.icrauthor | Houlston, Richard | |