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dc.contributor.authorMitchell, JS
dc.contributor.authorLi, N
dc.contributor.authorWeinhold, N
dc.contributor.authorFörsti, A
dc.contributor.authorAli, M
dc.contributor.authorvan Duin, M
dc.contributor.authorThorleifsson, G
dc.contributor.authorJohnson, DC
dc.contributor.authorChen, B
dc.contributor.authorHalvarsson, B-M
dc.contributor.authorGudbjartsson, DF
dc.contributor.authorKuiper, R
dc.contributor.authorStephens, OW
dc.contributor.authorBertsch, U
dc.contributor.authorBroderick, P
dc.contributor.authorCampo, C
dc.contributor.authorEinsele, H
dc.contributor.authorGregory, WA
dc.contributor.authorGullberg, U
dc.contributor.authorHenrion, M
dc.contributor.authorHillengass, J
dc.contributor.authorHoffmann, P
dc.contributor.authorJackson, GH
dc.contributor.authorJohnsson, E
dc.contributor.authorJöud, M
dc.contributor.authorKristinsson, SY
dc.contributor.authorLenhoff, S
dc.contributor.authorLenive, O
dc.contributor.authorMellqvist, U-H
dc.contributor.authorMigliorini, G
dc.contributor.authorNahi, H
dc.contributor.authorNelander, S
dc.contributor.authorNickel, J
dc.contributor.authorNöthen, MM
dc.contributor.authorRafnar, T
dc.contributor.authorRoss, FM
dc.contributor.authorda Silva Filho, MI
dc.contributor.authorSwaminathan, B
dc.contributor.authorThomsen, H
dc.contributor.authorTuresson, I
dc.contributor.authorVangsted, A
dc.contributor.authorVogel, U
dc.contributor.authorWaage, A
dc.contributor.authorWalker, BA
dc.contributor.authorWihlborg, A-K
dc.contributor.authorBroyl, A
dc.contributor.authorDavies, FE
dc.contributor.authorThorsteinsdottir, U
dc.contributor.authorLanger, C
dc.contributor.authorHansson, M
dc.contributor.authorKaiser, M
dc.contributor.authorSonneveld, P
dc.contributor.authorStefansson, K
dc.contributor.authorMorgan, GJ
dc.contributor.authorGoldschmidt, H
dc.contributor.authorHemminki, K
dc.contributor.authorNilsson, B
dc.contributor.authorHoulston, RS
dc.date.accessioned2017-02-01T12:10:48Z
dc.date.issued2016-07
dc.identifier.citationNature communications, 2016, 7 pp. 12050 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/396
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/ncomms12050
dc.description.abstractMultiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (rs9372120, P=9.09 × 10(-15)), 7q36.1 (rs7781265, P=9.71 × 10(-9)), 8q24.21 (rs1948915, P=4.20 × 10(-11)), 9p21.3 (rs2811710, P=1.72 × 10(-13)), 10p12.1 (rs2790457, P=1.77 × 10(-8)), 16q23.1 (rs7193541, P=5.00 × 10(-12)) and 20q13.13 (rs6066835, P=1.36 × 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
dc.formatElectronic
dc.format.extent12050 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectMultiple Myeloma
dc.subjectGenetic Predisposition to Disease
dc.subjectUbiquitin-Protein Ligases
dc.subjectAdaptor Proteins, Signal Transducing
dc.subjectGuanine Nucleotide Exchange Factors
dc.subjectTranscription Factors
dc.subjectCase-Control Studies
dc.subjectCyclin-Dependent Kinase Inhibitor p16
dc.subjectCyclin-Dependent Kinase Inhibitor p18
dc.subjectGenome-Wide Association Study
dc.subjectPolycomb Repressive Complex 2
dc.subjectRNA, Long Noncoding
dc.subjectAutophagy-Related Protein 5
dc.titleGenome-wide association study identifies multiple susceptibility loci for multiple myeloma.
dc.typeJournal Article
dcterms.dateAccepted2016-05-24
rioxxterms.versionofrecord10.1038/ncomms12050
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.publication-statusPublished
pubs.volume7
pubs.embargo.termsNo embargo
icr.researchteamCancer Genomicsen_US
icr.researchteamMolecular & Population Geneticsen_US
icr.researchteamMyeloma Groupen_US
dc.contributor.icrauthorLi, Nien
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorBroderick, Peteren
dc.contributor.icrauthorKaiser, Martinen
dc.contributor.icrauthorJohnson, Daviden


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