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dc.contributor.authorBodicoat, DHen_US
dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorMcFadden, Een_US
dc.contributor.authorGriffin, Jen_US
dc.contributor.authorAshworth, Aen_US
dc.contributor.authorSwerdlow, AJen_US
dc.date.accessioned2020-08-17T15:25:16Z
dc.date.issued2014-02-04en_US
dc.identifier.citationBreast cancer research : BCR, 2014, 16 (1), pp. R18 - ?en_US
dc.identifier.issn1465-5411en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3977
dc.identifier.eissn1465-542Xen_US
dc.identifier.doi10.1186/bcr3613en_US
dc.description.abstract<h4>Introduction</h4>Breast development and hormonal changes at puberty might affect breast cancer risk, but epidemiological analyses have focussed largely on age at menarche and not at other pubertal stages.<h4>Methods</h4>We investigated associations between the timing of pubertal stages and breast cancer risk using data from a cohort study of 104,931 women (Breakthrough Generations Study, UK, 2003-2013). Pubertal variables were reported retrospectively at baseline. Breast cancer risk was analysed using Cox regression models with breast cancer diagnosis as the outcome of interest, attained age as the underlying time variable, and adjustment for potentially confounding variables.<h4>Results</h4>During follow-up (mean = 4.1 years), 1094 breast cancers (including ductal carcinoma in situ) occurred. An increased breast cancer risk was associated with earlier thelarche (age when breast growth begins; HR [95% CI] = 1.23 [1.02, 1.48], 1 [referent] and 0.80 [0.69, 0.93] for ≤10, 11-12 and ≥13 years respectively), menarche (initiation of menses; 1.06 [0.93, 1.21], 1 [referent] and 0.78 [0.62, 0.99] for ≤12, 13-14 and ≥15 years), regular periods (0.99 [0.83, 1.18], 1 [referent] and 0.74 [0.59, 0.92] for ≤12, 13-14 and ≥15 years) and age reached adult height (1.25 [1.03, 1.52], 1 [referent] and 1.07 [0.87, 1.32] for ≤14, 15-16 and ≥17 years), and with increased time between thelarche and menarche (0.87 [0.65, 1.15], 1 [referent], 1.14 [0.96, 1.34] and 1.27 [1.04, 1.55] for <0, 0, 1 and ≥2 years), and shorter time between menarche and regular periods (1 [referent], 0.87 [0.73, 1.04] and 0.66 [0.50, 0.88] for 0, 1 and ≥2 years). These associations were generally similar when considered separately for premenopausal and postmenopausal breast cancer.<h4>Conclusions</h4>Breast duct development may be a time of heightened susceptibility to risk of carcinogenesis, and greater attention needs to be given to the relation of breast cancer risk to the different stages of puberty.en_US
dc.formatElectronicen_US
dc.format.extentR18 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBreasten_US
dc.subjectHumansen_US
dc.subjectCarcinoma, Intraductal, Noninfiltratingen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectDisease Susceptibilityen_US
dc.subjectRisken_US
dc.subjectRisk Factorsen_US
dc.subjectRetrospective Studiesen_US
dc.subjectCohort Studiesen_US
dc.subjectAge Factorsen_US
dc.subjectPubertyen_US
dc.subjectMenarcheen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectYoung Adulten_US
dc.subjectSurveys and Questionnairesen_US
dc.titleTiming of pubertal stages and breast cancer risk: the Breakthrough Generations Study.en_US
dc.typeJournal Article
dcterms.dateAccepted2014-01-30en_US
rioxxterms.versionofrecord10.1186/bcr3613en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2014-02-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBreast cancer research : BCRen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.publication-statusPublisheden_US
pubs.volume16en_US
pubs.embargo.termsNot knownen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamGene Functionen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorAshworth, Alanen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorJones, Michaelen_US


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