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dc.contributor.authorZuber, V
dc.contributor.authorMarconett, CN
dc.contributor.authorShi, J
dc.contributor.authorHua, X
dc.contributor.authorWheeler, W
dc.contributor.authorYang, C
dc.contributor.authorSong, L
dc.contributor.authorDale, AM
dc.contributor.authorLaplana, M
dc.contributor.authorRisch, A
dc.contributor.authorWitoelar, A
dc.contributor.authorThompson, WK
dc.contributor.authorSchork, AJ
dc.contributor.authorBettella, F
dc.contributor.authorWang, Y
dc.contributor.authorDjurovic, S
dc.contributor.authorZhou, B
dc.contributor.authorBorok, Z
dc.contributor.authorvan der Heijden, HFM
dc.contributor.authorde Graaf, J
dc.contributor.authorSwinkels, D
dc.contributor.authorAben, KK
dc.contributor.authorMcKay, J
dc.contributor.authorHung, RJ
dc.contributor.authorBikeböller, H
dc.contributor.authorStevens, VL
dc.contributor.authorAlbanes, D
dc.contributor.authorCaporaso, NE
dc.contributor.authorHan, Y
dc.contributor.authorWei, Y
dc.contributor.authorPanadero, MA
dc.contributor.authorMayordomo, JI
dc.contributor.authorChristiani, DC
dc.contributor.authorKiemeney, L
dc.contributor.authorAndreassen, OA
dc.contributor.authorHoulston, R
dc.contributor.authorAmos, CI
dc.contributor.authorChatterjee, N
dc.contributor.authorLaird-Offringa, IA
dc.contributor.authorMills, IG
dc.contributor.authorLandi, MT
dc.date.accessioned2017-02-01T12:12:27Z
dc.date.issued2016-12
dc.identifier.citationJournal of the National Cancer Institute, 2016, 108 (12)
dc.identifier.issn0027-8874
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/397
dc.identifier.eissn1460-2105
dc.identifier.doi10.1093/jnci/djw167
dc.description.abstractEpidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(-9)). The large sample size provided by the lipid GWAS data and the shared genetic risk factors between the two traits contributed to the uncovering of a hitherto unidentified genetic locus for lung cancer.
dc.formatPrint-Electronic
dc.languageeng
dc.language.isoeng
dc.subjectChromosomes, Human, Pair 6
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectCardiovascular Diseases
dc.subjectTriglycerides
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectPolymorphism, Single Nucleotide
dc.subjectMeta-Analysis as Topic
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Pleiotropy
dc.titlePleiotropic Analysis of Lung Cancer and Blood Triglycerides.
dc.typeJournal Article
dcterms.dateAccepted2016-05-31
rioxxterms.versionofrecord10.1093/jnci/djw167
rioxxterms.licenseref.startdate2016-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of the National Cancer Institute
pubs.issue12
pubs.notes6 months
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume108en_US
pubs.embargo.terms6 months
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorHoulston, Richarden


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