Pleiotropic Analysis of Lung Cancer and Blood Triglycerides.
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Date
2016-12-01ICR Author
Author
Zuber, V
Marconett, CN
Shi, J
Hua, X
Wheeler, W
Yang, C
Song, L
Dale, AM
Laplana, M
Risch, A
Witoelar, A
Thompson, WK
Schork, AJ
Bettella, F
Wang, Y
Djurovic, S
Zhou, B
Borok, Z
van der Heijden, HFM
de Graaf, J
Swinkels, D
Aben, KK
McKay, J
Hung, RJ
Bikeböller, H
Stevens, VL
Albanes, D
Caporaso, NE
Han, Y
Wei, Y
Panadero, MA
Mayordomo, JI
Christiani, DC
Kiemeney, L
Andreassen, OA
Houlston, R
Amos, CI
Chatterjee, N
Laird-Offringa, IA
Mills, IG
Landi, MT
Type
Journal Article
Metadata
Show full item recordAbstract
Epidemiologically related traits may share genetic risk factors, and pleiotropic analysis could identify individual loci associated with these traits. Because of their shared epidemiological associations, we conducted pleiotropic analysis of genome-wide association studies of lung cancer (12 160 lung cancer case patients and 16 838 control subjects) and cardiovascular disease risk factors (blood lipids from 188 577 subjects, type 2 diabetes from 148 821 subjects, body mass index from 123 865 subjects, and smoking phenotypes from 74 053 subjects). We found that 6p22.1 (rs6904596, ZNF184) was associated with both lung cancer (P = 5.50x10(-6)) and blood triglycerides (P = 1.39x10(-5)). We replicated the association in 6097 lung cancer case patients and 204 657 control subjects (P = 2.40 × 10(-4)) and in 71 113 subjects with triglycerides data (P = .01). rs6904596 reached genome-wide significance in lung cancer meta-analysis (odds ratio = 1.15, 95% confidence interval = 1.10 to 1.21 ,: Pcombined = 5.20x10(-9)). The large sample size provided by the lipid GWAS data and the shared genetic risk factors between the two traits contributed to the uncovering of a hitherto unidentified genetic locus for lung cancer.
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Subject
Chromosomes, Human, Pair 6
Humans
Lung Neoplasms
Cardiovascular Diseases
Triglycerides
Risk Factors
Case-Control Studies
Polymorphism, Single Nucleotide
Meta-Analysis as Topic
Genome-Wide Association Study
Genetic Pleiotropy
Research team
Cancer Genomics
Language
eng
Date accepted
2016-05-31
License start date
2016-12
Citation
Journal of the National Cancer Institute, 2016, 108 (12)
Publisher
OXFORD UNIV PRESS INC