dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Jones, ME | |
dc.contributor.author | Allen, S | |
dc.contributor.author | Hoare, J | |
dc.contributor.author | Ashworth, A | |
dc.contributor.author | Dowsett, M | |
dc.contributor.author | Swerdlow, AJ | |
dc.date.accessioned | 2017-02-01T12:20:37Z | |
dc.date.issued | 2017-02-07 | |
dc.identifier.citation | Breast cancer research : BCR, 2017, 19 (1), pp. 13 - ? | |
dc.identifier.issn | 1465-5411 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/399 | |
dc.identifier.eissn | 1465-542X | |
dc.identifier.doi | 10.1186/s13058-017-0804-y | |
dc.description.abstract | BACKGROUND: An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or predictors of onset of puberty, such as weight and height, are mediated via mammographic density, an important risk factor for breast cancer. METHODS: We investigated whether childhood body size and pubertal timing and tempo, collected by questionnaire, are associated with percentage and absolute area mammographic density at ages 47-73 years in 1105 women recruited to a prospective study. RESULTS: After controlling for adult adiposity, weight at ages 7 and 11 years was strongly significantly inversely associated with percentage and absolute dense area (p trend <0.001), and positively associated with absolute non-dense area. Greater height at age 7, but not age 11, was associated with lower percentage density (p trend = 0.016). Later age at menarche and age at when regular periods were established was associated with increased density, but additional adjustment for childhood weight attenuated the association. A longer interval between thelarche and menarche, and between thelarche and regular periods, was associated with increased dense area, even after adjusting for childhood weight (p trend = 0.013 and 0.028, respectively), and was independent of age at pubertal onset. CONCLUSIONS: Greater prepubertal weight and earlier pubertal onset are associated with lower adult breast density, but age at pubertal onset does not appear to have an independent effect on adult density after controlling for childhood adiposity. A possible effect of pubertal tempo on density needs further investigation. | |
dc.format | Electronic | |
dc.format.extent | 13 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BMC | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Body Weight | |
dc.subject | Mammography | |
dc.subject | Body Mass Index | |
dc.subject | Body Size | |
dc.subject | Body Height | |
dc.subject | Population Surveillance | |
dc.subject | Risk | |
dc.subject | Cross-Sectional Studies | |
dc.subject | Parity | |
dc.subject | Menopause | |
dc.subject | Menarche | |
dc.subject | Phenotype | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Child | |
dc.subject | Female | |
dc.subject | United Kingdom | |
dc.subject | Breast Density | |
dc.title | Childhood body size and pubertal timing in relation to adult mammographic density phenotype. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-01-12 | |
rioxxterms.versionofrecord | 10.1186/s13058-017-0804-y | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-02-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Breast cancer research : BCR | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 19 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Endocrinology | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Jones, Michael | |
dc.contributor.icrauthor | Hoare, Jean | |
dc.contributor.icrauthor | Swerdlow, Anthony | |