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dc.contributor.authorZhang, YD
dc.contributor.authorHurson, AN
dc.contributor.authorZhang, H
dc.contributor.authorChoudhury, PP
dc.contributor.authorEaston, DF
dc.contributor.authorMilne, RL
dc.contributor.authorSimard, J
dc.contributor.authorHall, P
dc.contributor.authorMichailidou, K
dc.contributor.authorDennis, J
dc.contributor.authorSchmidt, MK
dc.contributor.authorChang-Claude, J
dc.contributor.authorGharahkhani, P
dc.contributor.authorWhiteman, D
dc.contributor.authorCampbell, PT
dc.contributor.authorHoffmeister, M
dc.contributor.authorJenkins, M
dc.contributor.authorPeters, U
dc.contributor.authorHsu, L
dc.contributor.authorGruber, SB
dc.contributor.authorCasey, G
dc.contributor.authorSchmit, SL
dc.contributor.authorO'Mara, TA
dc.contributor.authorSpurdle, AB
dc.contributor.authorThompson, DJ
dc.contributor.authorTomlinson, I
dc.contributor.authorDe Vivo, I
dc.contributor.authorLandi, MT
dc.contributor.authorLaw, MH
dc.contributor.authorIles, MM
dc.contributor.authorDemenais, F
dc.contributor.authorKumar, R
dc.contributor.authorMacGregor, S
dc.contributor.authorBishop, DT
dc.contributor.authorWard, SV
dc.contributor.authorBondy, ML
dc.contributor.authorHoulston, R
dc.contributor.authorWiencke, JK
dc.contributor.authorMelin, B
dc.contributor.authorBarnholtz-Sloan, J
dc.contributor.authorKinnersley, B
dc.contributor.authorWrensch, MR
dc.contributor.authorAmos, CI
dc.contributor.authorHung, RJ
dc.contributor.authorBrennan, P
dc.contributor.authorMcKay, J
dc.contributor.authorCaporaso, NE
dc.contributor.authorBerndt, SI
dc.contributor.authorBirmann, BM
dc.contributor.authorCamp, NJ
dc.contributor.authorKraft, P
dc.contributor.authorRothman, N
dc.contributor.authorSlager, SL
dc.contributor.authorBerchuck, A
dc.contributor.authorPharoah, PDP
dc.contributor.authorSellers, TA
dc.contributor.authorGayther, SA
dc.contributor.authorPearce, CL
dc.contributor.authorGoode, EL
dc.contributor.authorSchildkraut, JM
dc.contributor.authorMoysich, KB
dc.contributor.authorAmundadottir, LT
dc.contributor.authorJacobs, EJ
dc.contributor.authorKlein, AP
dc.contributor.authorPetersen, GM
dc.contributor.authorRisch, HA
dc.contributor.authorStolzenberg-Solomon, RZ
dc.contributor.authorWolpin, BM
dc.contributor.authorLi, D
dc.contributor.authorEeles, RA
dc.contributor.authorHaiman, CA
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorSchumacher, FR
dc.contributor.authorAl Olama, AA
dc.contributor.authorPurdue, MP
dc.contributor.authorScelo, G
dc.contributor.authorDalgaard, MD
dc.contributor.authorGreene, MH
dc.contributor.authorGrotmol, T
dc.contributor.authorKanetsky, PA
dc.contributor.authorMcGlynn, KA
dc.contributor.authorNathanson, KL
dc.contributor.authorTurnbull, C
dc.contributor.authorWiklund, F
dc.contributor.authorBreast Cancer Association Consortium (BCAC)
dc.contributor.authorBarrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
dc.contributor.authorColon Cancer Family Registry (CCFR)
dc.contributor.authorTransdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT)
dc.contributor.authorEndometrial Cancer Association Consortium (ECAC)
dc.contributor.authorGenetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
dc.contributor.authorMelanoma Genetics Consortium (GenoMEL)
dc.contributor.authorGlioma International Case-Control Study (GICC)
dc.contributor.authorInternational Lung Cancer Consortium (ILCCO)
dc.contributor.authorIntegrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium
dc.contributor.authorInternational Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph)
dc.contributor.authorOvarian Cancer Association Consortium (OCAC)
dc.contributor.authorOral Cancer GWAS
dc.contributor.authorPancreatic Cancer Case-Control Consortium (PanC4)
dc.contributor.authorPancreatic Cancer Cohort Consortium (PanScan)
dc.contributor.authorProstate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL)
dc.contributor.authorRenal Cancer GWAS
dc.contributor.authorTesticular Cancer Consortium (TECAC)
dc.contributor.authorChanock, SJ
dc.contributor.authorChatterjee, N
dc.contributor.authorGarcia-Closas, M
dc.date.accessioned2020-08-27T09:08:52Z
dc.date.issued2020-07-03
dc.identifier.citationNature communications, 2020, 11 (1), pp. 3353 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4032
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/s41467-020-16483-3en_US
dc.description.abstractGenome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. We project that sample sizes required to explain 80% of GWAS heritability vary from 60,000 cases for testicular to over 1,000,000 cases for lung cancer. The maximum relative risk achievable for subjects at the 99th risk percentile of underlying polygenic risk scores (PRS), compared to average risk, ranges from 12 for testicular to 2.5 for ovarian cancer. We show that PRS have potential for risk stratification for cancers of breast, colon and prostate, but less so for others because of modest heritability and lower incidence.
dc.formatElectronic
dc.format.extent3353 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBreast Cancer Association Consortium (BCAC)
dc.subjectBarrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
dc.subjectColon Cancer Family Registry (CCFR)
dc.subjectTransdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT)
dc.subjectEndometrial Cancer Association Consortium (ECAC)
dc.subjectGenetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
dc.subjectMelanoma Genetics Consortium (GenoMEL)
dc.subjectGlioma International Case-Control Study (GICC)
dc.subjectInternational Lung Cancer Consortium (ILCCO)
dc.subjectIntegrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium
dc.subjectInternational Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph)
dc.subjectOvarian Cancer Association Consortium (OCAC)
dc.subjectOral Cancer GWAS
dc.subjectPancreatic Cancer Case-Control Consortium (PanC4)
dc.subjectPancreatic Cancer Cohort Consortium (PanScan)
dc.subjectProstate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL)
dc.subjectRenal Cancer GWAS
dc.subjectTesticular Cancer Consortium (TECAC)
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectIncidence
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectMultifactorial Inheritance
dc.subjectPolymorphism, Single Nucleotide
dc.subjectModels, Genetic
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.titleAssessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
dc.typeJournal Article
dcterms.dateAccepted2020-05-04
rioxxterms.versionofrecord10.1038/s41467-020-16483-3
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-07-03en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume11en_US
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorTurnbull, Clareen
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorKinnersley, Benjaminen


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