Klotho: A Major Shareholder in Vascular Aging Enterprises.
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Date
2019-09-19ICR Author
Author
Lim, K
Halim, A
Lu, T-S
Ashworth, A
Chong, I
Type
Journal Article
Metadata
Show full item recordAbstract
Accelerated vascular aging is a condition that occurs as a complication of several highly prevalent inflammatory conditions such as chronic kidney disease, cancer, HIV infection and diabetes. Age-associated vascular alterations underlie a continuum of expression toward clinically overt cardiovascular disease. This has contributed to the striking epidemiologic transition whereby such noncommunicable diseases have taken center stage as modern-day global epidemics and public health problems. The identification of α-Klotho, a remarkable protein that confers powerful anti-aging properties has stimulated significant interest. In fact, emerging data have provided fundamental rationale for Klotho-based therapeutic intervention for vascular diseases and multiple other potential indications. However, the application of such discoveries in Klotho research remains fragmented due to significant gaps in our molecular understanding of Klotho biology, as well as hurdles in clinical research and experimental barriers that must first be overcome. These advances will be critical to establish the scientific platform from which future Klotho-based interventional trials and therapeutic enterprises can be successfully launched.
Collections
Subject
Animals
Humans
Neoplasms
Vascular Diseases
Diabetes Mellitus
Glucuronidase
Neoplasm Proteins
Aging
Renal Insufficiency, Chronic
Research team
Ashworth Collaborators
Language
eng
Date accepted
2019-09-13
License start date
2019-09-19
Citation
International journal of molecular sciences, 2019, 20 (18)
Publisher
MDPI