MicroRNAs as mediators of drug resistance mechanisms.
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Date
2020-10-01Author
Lampis, A
Hahne, JC
Hedayat, S
Valeri, N
Type
Journal Article
Metadata
Show full item recordAbstract
MicroRNAs are small RNA transcripts involved in fine-tuning of several cellular mechanisms and pathways crucial for maintaining cells' homeostasis like apoptosis, differentiation, inflammation and cell-cycle regulation. They act by regulation of gene expression at post-transcriptional level through fine-tuning of target proteins expression. Expression of microRNAs is cell-type specific and since their discovery they have been proven to be deregulated in various disorders including cancer. Several lines of evidence are emerging that link microRNAs to drug resistance mechanisms in tumours given their important role in modulating oncogenic and tumour suppressive mechanisms. This review will focus on latest knowledge of the roles and mechanisms of microRNAs as mediators to drug resistance and the implications for future therapies.
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Research team
Evolutionary Genomics & Modelling
Functional Genomics
Gastrointestinal Cancer Biology and Genomics
Language
eng
Date accepted
2020-08-05
License start date
2020-10
Citation
Current opinion in pharmacology, 2020, 54 pp. 44 - 50
Publisher
ELSEVIER SCI LTD