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dc.contributor.authorThomas, DC
dc.contributor.authorClare, S
dc.contributor.authorSowerby, JM
dc.contributor.authorPardo, M
dc.contributor.authorJuss, JK
dc.contributor.authorGoulding, DA
dc.contributor.authorvan der Weyden, L
dc.contributor.authorStoristeanu, D
dc.contributor.authorPrakash, A
dc.contributor.authorEspéli, M
dc.contributor.authorFlint, S
dc.contributor.authorLee, JC
dc.contributor.authorHoenderdos, K
dc.contributor.authorKane, L
dc.contributor.authorHarcourt, K
dc.contributor.authorMukhopadhyay, S
dc.contributor.authorUmrania, Y
dc.contributor.authorAntrobus, R
dc.contributor.authorNathan, JA
dc.contributor.authorAdams, DJ
dc.contributor.authorBateman, A
dc.contributor.authorChoudhary, JS
dc.contributor.authorLyons, PA
dc.contributor.authorCondliffe, AM
dc.contributor.authorChilvers, ER
dc.contributor.authorDougan, G
dc.contributor.authorSmith, KGC
dc.date.accessioned2020-10-15T15:38:26Z
dc.date.issued2017-04
dc.identifier.citationThe Journal of experimental medicine, 2017, 214 (4), pp. 1111 - 1128
dc.identifier.issn0022-1007
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4165
dc.identifier.eissn1540-9538
dc.identifier.doi10.1084/jem.20161382
dc.description.abstractThe phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91 phox and p22 phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen species), a protein encoded by the previously undefined mouse gene bc017643 , and show that it is essential for host defense via the phagocyte NAPDH oxidase. Eros is required for expression of the NADPH oxidase components, gp91 phox and p22 phox Consequently, Eros -deficient mice quickly succumb to infection. Eros also contributes to the formation of neutrophil extracellular traps (NETS) and impacts on the immune response to melanoma metastases. Eros is an ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthetic photosystem 1 complex, itself also an NADPH oxio-reductase. We thus describe the key role of the previously uncharacterized protein Eros in host defense.
dc.formatPrint-Electronic
dc.format.extent1111 - 1128
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectNeutrophils
dc.subjectEndoplasmic Reticulum
dc.subjectMacrophages
dc.subjectPhagocytes
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectHumans
dc.subjectMice
dc.subjectReactive Oxygen Species
dc.subjectCytochrome b Group
dc.subjectMembrane Glycoproteins
dc.subjectMembrane Proteins
dc.subjectRespiratory Burst
dc.subjectPhagocytosis
dc.subjectImmunity, Innate
dc.subjectHEK293 Cells
dc.subjectNADPH Oxidase 2
dc.subjectNADPH Oxidases
dc.titleEros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
dc.typeJournal Article
dcterms.dateAccepted2017-01-20
rioxxterms.versionofrecord10.1084/jem.20161382
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe Journal of experimental medicine
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Functional Proteomics Group
pubs.publication-statusPublished
pubs.volume214
pubs.embargo.termsNot known
icr.researchteamFunctional Proteomics Groupen_US
dc.contributor.icrauthorPardo Calvo, Maria Mercedesen
dc.contributor.icrauthorChoudhary, Jyotien


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