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dc.contributor.authorBayés, À
dc.contributor.authorCollins, MO
dc.contributor.authorReig-Viader, R
dc.contributor.authorGou, G
dc.contributor.authorGoulding, D
dc.contributor.authorIzquierdo, A
dc.contributor.authorChoudhary, JS
dc.contributor.authorEmes, RD
dc.contributor.authorGrant, SGN
dc.date.accessioned2020-10-16T09:20:11Z
dc.date.issued2017-03-02
dc.identifier.citationNature communications, 2017, 8 pp. 14613 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4168
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/ncomms14613
dc.description.abstractThe proteome of human brain synapses is highly complex and is mutated in over 130 diseases. This complexity arose from two whole-genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases; however, its synapse proteome is uncharacterized, and whether the teleost-specific genome duplication (TSGD) influenced complexity is unknown. We report the characterization of the proteomes and ultrastructure of central synapses in zebrafish and analyse the importance of the TSGD. While the TSGD increases overall synapse proteome complexity, the postsynaptic density (PSD) proteome of zebrafish has lower complexity than mammals. A highly conserved set of ∼1,000 proteins is shared across vertebrates. PSD ultrastructural features are also conserved. Lineage-specific proteome differences indicate that vertebrate species evolved distinct synapse types and functions. The data sets are a resource for a wide range of studies and have important implications for the use of zebrafish in modelling human synaptic diseases.
dc.formatElectronic
dc.format.extent14613 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectBrain
dc.subjectSynapses
dc.subjectSynaptosomes
dc.subjectAnimals
dc.subjectZebrafish
dc.subjectMice
dc.subjectZebrafish Proteins
dc.subjectNerve Tissue Proteins
dc.subjectProteome
dc.subjectMicroscopy, Electron, Transmission
dc.subjectSpecies Specificity
dc.subjectGene Duplication
dc.subjectGenome
dc.subjectModels, Biological
dc.subjectFemale
dc.subjectMale
dc.subjectPost-Synaptic Density
dc.titleEvolution of complexity in the zebrafish synapse proteome.
dc.typeJournal Article
dcterms.dateAccepted2017-01-15
rioxxterms.versionofrecord10.1038/ncomms14613
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-03-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.publication-statusPublished
pubs.volume8
pubs.embargo.termsNot known
dc.contributor.icrauthorChoudhary, Jyoti


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