Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
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Date
2018-05-09Author
Ostrom, QT
Kinnersley, B
Wrensch, MR
Eckel-Passow, JE
Armstrong, G
Rice, T
Chen, Y
Wiencke, JK
McCoy, LS
Hansen, HM
Amos, CI
Bernstein, JL
Claus, EB
Il'yasova, D
Johansen, C
Lachance, DH
Lai, RK
Merrell, RT
Olson, SH
Sadetzki, S
Schildkraut, JM
Shete, S
Rubin, JB
Lathia, JD
Berens, ME
Andersson, U
Rajaraman, P
Chanock, SJ
Linet, MS
Wang, Z
Yeager, M
GliomaScan consortium,
Houlston, RS
Jenkins, RB
Melin, B
Bondy, ML
Barnholtz-Sloan, JS
Type
Journal Article
Metadata
Show full item recordAbstract
Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.
Collections
Subject
GliomaScan consortium
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 8
Humans
Glioma
Brain Neoplasms
Genetic Predisposition to Disease
Logistic Models
Odds Ratio
Risk Factors
Case-Control Studies
Sex Factors
Genotype
Polymorphism, Single Nucleotide
Alleles
Adult
Middle Aged
Female
Male
Genome-Wide Association Study
Research team
Cancer Genomics
Language
eng
Date accepted
2018-04-06
License start date
2018-05-09
Citation
Scientific reports, 2018, 8 (1), pp. 7352 - ?
Publisher
NATURE PORTFOLIO