Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study.
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Date
2018-06-01ICR Author
Author
Berntsson, SG
Merrell, RT
Amirian, ES
Armstrong, GN
Lachance, D
Smits, A
Zhou, R
Jacobs, DI
Wrensch, MR
Olson, SH
Il'yasova, D
Claus, EB
Barnholtz-Sloan, JS
Schildkraut, J
Sadetzki, S
Johansen, C
Houlston, RS
Jenkins, RB
Bernstein, JL
Lai, R
Shete, S
Amos, CI
Bondy, ML
Melin, BS
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. METHODS: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. RESULTS: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. CONCLUSIONS: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.
Collections
Subject
Humans
Glioma
Brain Neoplasms
Seizures
Case-Control Studies
Retrospective Studies
Internationality
Adolescent
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Young Adult
Neoplasm Grading
Surveys and Questionnaires
Research team
Cancer Genomics
Language
eng
Date accepted
2018-04-02
License start date
2018-06
Citation
Journal of neurology, 2018, 265 (6), pp. 1432 - 1442
Publisher
SPRINGER HEIDELBERG