dc.contributor.author | Takata, R | |
dc.contributor.author | Takahashi, A | |
dc.contributor.author | Fujita, M | |
dc.contributor.author | Momozawa, Y | |
dc.contributor.author | Saunders, EJ | |
dc.contributor.author | Yamada, H | |
dc.contributor.author | Maejima, K | |
dc.contributor.author | Nakano, K | |
dc.contributor.author | Nishida, Y | |
dc.contributor.author | Hishida, A | |
dc.contributor.author | Matsuo, K | |
dc.contributor.author | Wakai, K | |
dc.contributor.author | Yamaji, T | |
dc.contributor.author | Sawada, N | |
dc.contributor.author | Iwasaki, M | |
dc.contributor.author | Tsugane, S | |
dc.contributor.author | Sasaki, M | |
dc.contributor.author | Shimizu, A | |
dc.contributor.author | Tanno, K | |
dc.contributor.author | Minegishi, N | |
dc.contributor.author | Suzuki, K | |
dc.contributor.author | Matsuda, K | |
dc.contributor.author | Kubo, M | |
dc.contributor.author | Inazawa, J | |
dc.contributor.author | Egawa, S | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Ogawa, O | |
dc.contributor.author | Obara, W | |
dc.contributor.author | Kamatani, Y | |
dc.contributor.author | Akamatsu, S | |
dc.contributor.author | Nakagawa, H | |
dc.date.accessioned | 2021-01-27T09:27:35Z | |
dc.date.issued | 2019-09-27 | |
dc.identifier.citation | Nature communications, 2019, 10 (1), pp. 4422 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4319 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-019-12267-6 | |
dc.description.abstract | Genome-wide association studies (GWAS) have identified ~170 genetic loci associated with prostate cancer (PCa) risk, but most of them were identified in European populations. We here performed a GWAS and replication study using a large Japanese cohort (9,906 cases and 83,943 male controls) to identify novel susceptibility loci associated with PCa risk. We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10-16), rs73862213 (GATA2, P = 5.87 × 10-23), rs77911174 (ZMIZ1, P = 5.28 × 10-20), and rs138708 (SUN2, P = 1.13 × 10-15), seven of which had crucially low minor allele frequency in European population. Furthermore, we stratified the polygenic risk for Japanese PCa patients by using 82 SNPs, which were significantly associated with Japanese PCa risk in our study, and found that early onset cases and cases with family history of PCa were enriched in the genetically high-risk population. Our study provides important insight into genetic mechanisms of PCa and facilitates PCa risk stratification in Japanese population. | |
dc.format | Electronic | |
dc.format.extent | 4422 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Intracellular Signaling Peptides and Proteins | |
dc.subject | Membrane Proteins | |
dc.subject | Transcription Factors | |
dc.subject | Risk Factors | |
dc.subject | Gene Frequency | |
dc.subject | Genotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Alleles | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Japan | |
dc.subject | Male | |
dc.subject | GATA2 Transcription Factor | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Loci | |
dc.subject | Transcriptome | |
dc.subject | Genotyping Techniques | |
dc.title | 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-09-02 | |
rioxxterms.versionofrecord | 10.1038/s41467-019-12267-6 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-09-27 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/18/19 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 10 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Saunders, Edward | |